KEGG ENZYME: 2.5.1.134

ENZYME: 2.5.1.134

Entry

EC 2.5.1.134                Enzyme

Name

cystathionine beta-synthase (O-acetyl-L-serine);
MccB;
O-acetylserine dependent cystathionine beta-synthase

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

O-acetyl-L-serine:L-homocysteine 2-amino-2-carboxyethyltransferase

Reaction(IUBMB)

O-acetyl-L-serine + L-homocysteine = L-cystathionine + acetate [RN:R10305]

Reaction(KEGG)

R10305

Substrate

O-acetyl-L-serine [CPD:C00979];
L-homocysteine [CPD:C00155]

Product

L-cystathionine [CPD:C02291];
acetate [CPD:C00033]

Comment

A pyridoxal 5'-phosphate protein. The enzyme, purified from the bacterium Bacillus subtilis, also has a low activity with L-serine (cf. EC 4.2.1.22, cystathionine beta-synthase).

History

EC 2.5.1.134 created 2016

Pathway

ec00270

Cysteine and methionine metabolism

ec01100

Metabolic pathways

Orthology

K17216

cystathionine beta-synthase (O-acetyl-L-serine)

Genes

SDO:	SD1155_04925

BSU:	BSU27260(mccA)

BSR:

I33_2768

BSL:

A7A1_0368

BSH:	BSU6051_27260(mccA)

BSY:	I653_12945

BSUT:

BSUB_02908(mccA)

BSUL:

BSUA_02908(mccA)

BSUS:

Q433_14685

BSO:	BSNT_09120(yrhA)

BSN:	BSn5_04415

BSQ:	B657_27260(mccA)

BSX:	C663_2563(mccA)

BSP:	U712_13400

BSS:	BSUW23_13185(mccA)

BST:

GYO_2966

BIT:	BIS30_03015

BLI:	BL02019(yrhA)

BLD:	BLi02854(mccA)

BLH:	BaLi_c29550(mccA)

BAY:	RBAM_024360

BAQ:	BACAU_2450(yrhA)

BYA:	BANAU_2594(yrhA)

BAMP:

B938_12590

BQY:	MUS_2912(yrhA)

BAML:

BAM5036_2376(mccA)

BAMA:

RBAU_2573(mccA)

BAMN:

BASU_2379(mccA)

BAMB:

BAPNAU_1126(yrhA)

BAMT:

AJ82_13765

BAMY:

V529_27200(yrhA)

BMP:	NG74_02558(mccA)

BAO:	BAMF_2534(mccA)

BAZ:	BAMTA208_13375(mccA)

BQL:	LL3_02812(mccA)

BXH:	BAXH7_02736(yrhA)

BAMI:

KSO_007195

BAMC:

U471_25280

BAMF:

U722_13220

BSIA:

CWD84_08700

BAE:	BATR1942_11345

BVM:	B9C48_12460

BSON:

S101395_01637

BHT:	DIC78_18025

BMOJ:

HC660_25290(mccA)

BTEQ:

G4P54_13890

BIQ:	AN935_13315

BSTR:

QI003_16795(mccA)

BAN:	BA_4601(cysM)

BAR:	GBAA_4601(cysM)

BAT:

BAS4269

BAH:	BAMEG_4638(cysM)

BAI:	BAA_4621(cysM)

BAX:	H9401_4390

BANT:

A16_45990

BANR:

A16R_60350

BANS:

BAPAT_4416

BANH:

HYU01_22440

BANV:

DJ46_3278(mccA)

BCE:

BC4367

BCA:	BCE_4455(cysM)

BCZ:	BCE33L4117(cysM)

BCR:	BCAH187_A4506(cysM)

BCB:	BCB4264_A4492(cysM)

BCU:	BCAH820_4453(cysM)

BCG:	BCG9842_B0744(cysM)

BCQ:	BCQ_4157(cysM)

BCX:	BCA_4485(cysM)

BAL:	BACI_c43590(cysM)

BNC:

BCN_4283

BCF:

bcf_21750

BCER:

BCK_13330

BCY:	Bcer98_3085

BTK:	BT9727_4106(cysM)

BTL:	BALH_3958(cysM)

BTB:	BMB171_C4034(cysM)

BTT:

HD73_4681

BTHR:

YBT1520_23215

BTHI:

BTK_23055

BTC:	CT43_CH4390(cysM)

BTF:	YBT020_21540

BTM:

MC28_3664

BTG:	BTB_c45130(mccA)

BTI:

BTG_27210

BTN:	BTF1_20470

BTHT:

H175_ch4459

BTHU:

YBT1518_24320

BTW:	BF38_127(mccA)

BTHY:

AQ980_07955

BWE:	BcerKBAB4_4220

BWW:	bwei_0566(mccA)

BMYO:

BG05_1653

BTY:	Btoyo_1610

BMYC:

DJ92_1470(mccA)

BBY:	CY96_21040

BWD:	CT694_23490

BTRO:

FJR70_15655

BMOB:

MLA2C4_22815

BNT:	GSN03_20805

BPAC:

LMD38_05140

BPAN:

NLJ82_21255

BALU:

QRY64_24760

BPU:

BPUM_2361

BPUM:

BW16_12820

BPUS:

UP12_11890

BIF:	N288_18660

BMET:

BMMGA3_12175(mccA)

BSM:	BSM4216_1793

BGY:	BGLY_3173(yrhA)

BXI:	BK049_15165

BALT:

CFN77_12620

BAER:

BAE_00310

BSAF:

BSL056_12970

BSHI:

LGQ02_13710

BCAB:

EFK13_13840

BRY:	M0696_13615

BJS:

MY9_2707

BACI:

B1NLA3E_16325

GST:	HW35_04710

BACW:

QR42_11965

BACP:

SB24_16515

BACB:

OY17_15460

BACY:

QF06_11820

BACL:

BS34A_29740(mccA)

BALM:

BsLM_2695

BACS:

AUL54_17635

BACA:

FAY30_17475

BAQU:

K6959_18315

BZH:	NF868_10635

BHAI:

KJK41_15820

BCAO:

LC087_07940

BARD:

QRY57_21570

BAEI:

RE735_07965

BHK:	B4U37_15540

BCOH:

BC6307_15900

BCIR:

C2I06_10460(cysK)

NTX:	NQZ71_07955

BMQ:	BMQ_4595(mccA)

BMD:	BMD_4581(mccA)

BMEG:

BG04_1587

BEO:

BEH_16505

BFX:	BC359_04740

PKS:	IE339_19405

BCL:

ABC1944

BLE:	BleG1_1699

SHUA:

PQ477_17360

BGI:	BGM20_07525

BKO:	CKF48_17420

CGOT:

J1899_15730

CSUA:

IM538_17680(cysK)

CFIR:

NAF01_02890

CSOA:

LIS82_19850

CSPG:

LS684_14030

CPSS:

M5V91_19245

OIH:	OB1108(cysK)

OCN:	CUC15_07020

GKA:

GK2541

GTE:	GTCCBUS3UF5_28640

GTK:	GT3570_12445

GTM:	GT3921_06740

GLI:	GLN3_05580

BCAL:

CWI35_15565

GTN:

GTNG_2474

GWC:	GWCH70_2475

GYC:	GYMC61_0978

GYA:	GYMC52_2574

GCT:	GC56T3_0951

GMC:	GY4MC1_1026

GGH:	GHH_c26150(mccA)

GJF:	M493_13175

GEA:	GARCT_02595(mccA)

GEL:	IB49_04575

GSE:	GT50_04125

GSR:	GS3922_03470

GEJ:	A0V43_10575

GZA:	IC807_08845

GTH:	Geoth_1096

PTL:	AOT13_17160

PTB:	DER53_00270

PCAL:

BV455_02800(mccA)

PARG:

PspKH34_09430(cysM)

AFL:

Aflv_0760

AGN:	AFK25_10610

ANM:	GFC28_3611

AAMY:

GFC30_2790

ANL:	GFC29_1822

AND:	GRQ40_13475

ACAI:

ISX45_10950

ASED:

IRT44_02025(cysK)

HHD:	HBHAL_2022(mccA)

HMN:	HM131_16230

HLI:

HLI_06380

HNZ:	P9989_05810

HSAN:

MUN89_17585

HSHI:

MUO14_19470

HAMY:

MUO15_07765

TAP:	GZ22_04625

TAID:

KS242_05460

VHL:	BME96_04130

VIL:	CFK37_01105

VNE:	CFK40_17140

VIM:	GWK91_05710

VNT:	OLD84_06870

VIK:	KFZ58_06630

LEX:	Len3610_01580

FPN:	ABE65_014680

FAR:	ABE41_013450

FEC:	QNH15_16610

BSJ:	UP17_16920

BMUR:

ABE28_015670

PBUT:

DTO10_03735

PASA:

BAOM_3879(mccA)

PPSR:

I6J18_20130

PFRI:

L8956_17560

AQT:	FN924_05325(cysK)

RAX:	KO561_05550(cysK)

BTHV:

CQJ30_10405

PSYH:

D0S48_17715

PSYO:

PB01_15155

PSYB:

KD050_05315

GRC:	GI584_17705

GCS:	MUN88_11625

GSM:	MUN87_07240

POF:	GS400_02550

PCHU:

QNI29_02080

NTM:	BTDUT50_12140

NDT:	L1999_22115

NCM:	QNK12_23490(cysK)

NNV:	QNH39_19440

MSEM:

GMB29_13385

MDG:	K8L98_18135

BLEN:

NCTC4824_00045(mccA)

SEDD:

ERJ70_04080

BVQ:	FHE72_15535

RMF:	D5E69_15365

RAZ:	U9J35_15735

BCK:	BCO26_2431

BAG:

Bcoa_1960

BCOA:

BF29_1573

BVJ:	I5776_17575

BOU:	I5818_21620

CTHU:

HUR95_16175(cysK)

MCUI:

G8O30_08390

GAJ:	MY490_08845

PSUA:

FLK61_25190

SLMS:

MM221_11370

MJO:	FOF60_09735

MSUT:

LC048_11960

ECTO:

MUG87_08355

ALKG:

MOJ78_14255

PHJ:	LC071_04675

STEA:

C0679_09630

SAU:	SA0418(cysM)

SAV:	SAV0459(cysM)

SAW:	SAHV_0457(cysM)

SAH:	SaurJH1_0494

SAJ:	SaurJH9_0481

SAM:	MW0414(cysM)

SAS:

SAS0417

SAR:

SAR0459

SAC:

SACOL0502

SAA:	SAUSA300_0433(cysM)

SAO:	SAOUHSC_00421

SAE:	NWMN_0424(cysM)

SAD:

SAAV_0402

SUU:	M013TW_0424

SUV:	SAVC_01885

SUE:

SAOV_0477

SUJ:	SAA6159_00409

SUK:	SAA6008_00463(cysM)

SUC:

ECTR2_393

SUT:	SAT0131_00499

SUQ:	HMPREF0772_10063

SUZ:	MS7_0433(mccA)

SUD:	ST398NM01_0525

SUX:	SAEMRSA15_03850

SUW:	SATW20_05280

SUG:

SAPIG0525

SUF:	SARLGA251_03930

SAUA:

SAAG_00914

SAUE:

RSAU_000392(cysM)

SAUN:

SAKOR_00443

SAUS:

SA40_0398

SAUU:

SA957_0413

SAUG:

SA268_0411

SAUZ:

SAZ172_0461

SAUT:

SAI1T1_2003350

SAUJ:

SAI2T2_1003350

SAUK:

SAI3T3_1003350

SAUQ:

SAI4T8_1003350

SAUV:

SAI7S6_1003350

SAUW:

SAI5S5_1003340

SAUX:

SAI6T6_1003350

SAUY:

SAI8T7_1003350

SAUF:

X998_0486

SAB:

SAB0409

SUY:	SA2981_0435(cysM)

SAUB:

C248_0509

SAUM:

BN843_4420

SAUC:

CA347_453(mccA)

SAUR:

SABB_06041

SAUI:

AZ30_02225

SAUD:

CH52_03555

SAMS:

NI36_02150

SUH:	SAMSHR1132_04040

SER:

SERP0094

SEP:

SE_2324

SEPP:

SEB_02319

SEPS:

DP17_1514

SHA:	SH2549(cysM)

SHH:	ShL2_02334(cysM)

SSP:

SSP0252

SCA:	SCA_0086(cysM)

SLG:	SLGD_02457

SLN:	SLUG_23520

SSD:	SPSINT_0115

SDT:

SPSE_2356

SDP:	NCTC12225_02562(mccA)

SWA:	A284_11090

SPAS:

STP1_1534

SXY:	BE24_10695

SXL:	SXYLSMQ121_0280

SXO:	SXYL_00284(cysM)

SHU:	SHYC_11455(mccA)

SCAP:

AYP1020_2182(mccA)

SSCH:

LH95_11035

SSCZ:

RN70_11800

SAGQ:

EP23_10725

SEQO:

SE1039_22910

SSIF:

AL483_09475

SCV:	A4G25_07305

SLZ:	B5P37_06595

SFQ:	C7J90_02465

SHOM:

EGX58_04085

SMUS:

C7J88_06870

SCAR:

DWB96_12390

SCHR:

DWB92_11610

SPIC:

SAMEA4384060_2444(cysM)

SSH:	NCTC13712_00385(mccA)

SSIM:

SAMEA4384339_0377(mccA)

SDB:	CNQ82_00635

SAUL:

I6G39_10120

SRAI:

LN051_10785

SPSD:

JMB28_01920

STAS:

HYI43_11700

SEDA:

MNY58_01475

SCAQ:

QMO72_01555

SDEV:

Q2T90_07420

SROT:

ML435_01980

STAP:

AOB58_2110

SSCU:

CEP64_10515

SFF:	FOB90_08360

SSTE:

SAMEA4384403_2190(mccA)

MVT:	I6J10_00360

MACR:

BHM04_11960

MARY:

LAU42_10665

MBRU:

MGG13_10085

MEQU:

KFV11_10175

MBOC:

QSV55_10285

MCL:

MCCL_1789

MCAK:

MCCS_23050(cysM)

MBOE:

HT586_11095

SBAC:

BVH56_07770

ESI:

Exig_2344

EAT:	EAT1b_0609

EAN:

Eab7_2189

EXM:	U719_12905

EXU:	ESP131_15015

EAP:	KB235_07390

EACE:

KKI46_12850

EAUR:

NMQ00_06110

EMM:	PTI97_08765

EPF:	OE059_05810

BBE:	BBR47_47860(mccA)

BLR:	BRLA_c040920

BFM:	BP422_19715

BAGR:

BA6348_07555(cysK)

BRW:	GOP56_13105(cysK)

BCHS:

JNE38_25760(cysK)

BCOP:

JD108_05015(cysK)

BPAB:

PSE45_22785(cysK)

BHUI:

LOK74_16640(cysK)

BAYD:

BSPP4475_03820(cysK)

BBOR:

RFB14_05020(cysK)

BRUM:

NDK47_05850(cysK)

PJD:	Pjdr2_5105

PPY:

PPE_02106

PPM:	PPSC2_11030(cysM)

PPO:	PPM_2115(cysM)

PPOL:

X809_11375

PPQ:	PPSQR21_021950

PPOY:

RE92_01320

PTA:	HPL003_19385

PIH:	UB51_24980

PPEO:

ABE82_11205

PBV:	AR543_13265

PXL:	BS614_24795

PKB:	B4V02_14235

PAIH:

ASL14_00330

PKA:	PQ456_10630

PAMY:

P9222_15310

PNK:	AASFL403_08260

ANX:	ACH33_03435

ASOC:

CB4_01040(mccA)

ATHE:

K3F53_15480(cysK)

PLN:	Plano_2472

PKU:	AUO94_03265

PRT:	AUC31_13725

PLL:	I858_010420

PANA:

BBH88_06550

PDG:	BCM40_02835

PHC:	BBI08_09605

PMAR:

B0X71_15405

PPLA:

BBI15_08585

PFAE:

AJGP001_14285

PLX:	CW734_14635

PMAT:

BBI11_14205

PDEC:

H1Q58_13510

PGQ:	FK545_03595

JEO:

JMA_30780

SPSY:

AZE41_06755

SPOO:

J3U78_10520

RST:	ATY39_01125

PAEK:

D3873_09805

PANC:

E2636_04655

PLAY:

DNR44_007330

VIJ:	JNUCC6_21810

NTR:	B0W44_08995

LFB:	C1X05_03175(cysK)

TVU:	AB849_002180(cysK)

KPUL:

GXN76_04265(cysK)

KEB:	GXN75_04825

PABS:

JIR001_06870(cysM)

CRN:	CAR_c05780(mccA)

CVD:	LHA31_04145

BACG:

D2962_10710(cysK)

ACIT:

HPK19_02685

HSL:	OE_1916F(cysK1)

HDL:	HALDL1_07230

HHB:	Hhub_1695(cysK1)

HAGS:

JT689_03820

SALR:

FQU85_11785

HJE:	HacjB3_11215

HALX:

M0R89_11725

HAXZ:

M0R88_11985

HAYC:

NGM10_02915

HAXY:

NGM07_00290

SALI:

L593_14755

NPH:	NP_4748A(cysK1)

NHO:	HWV23_10835

NSAL:

HWV07_06325

HUT:

Huta_0932

HTI:

HTIA_0785

HALA:

Hrd1104_04120

HME:	HFX_1504(cysK1)

HGI:	ABY42_07000

HALE:

G3A49_10355

HBO:	Hbor_18020

HALM:

FCF25_14070

HLA:

Hlac_1763

HALP:

DOS48_04315

HALB:

EKH57_04805

HEZZ:

EO776_07060

HALQ:

Hrr1229_015785

HSS:	J7656_09400

HSAI:

HPS36_14840

HAZZ:

KI388_04730

HALN:

B4589_002670

HALG:

HUG10_06270

HALU:

HUG12_10185

HMP:	K6T50_05640

HRE:	K6T36_05370

HRM:	K6T25_10395

HACB:

Hbl1158_11970

HDF:	AArcSl_1390(cysK2)

HAH:	Halar_2309

HTU:

Htur_1013

HSAL:

JMJ58_03860

NMG:	Nmag_3195(cysK1)

HXA:	Halxa_2901

NVR:	FEJ81_12600

NGE:	Natgr_0629

HRU:	Halru_0862

NOU:	Natoc_1061

HLC:	CHINAEXTREME17445

NAG:	AArcMg_1441

NAN:	AArc1_2155

» show all

Reference

1 [PMID:17056751]

Authors

Hullo MF, Auger S, Soutourina O, Barzu O, Yvon M, Danchin A, Martin-Verstraete I

Title

Conversion of methionine to cysteine in Bacillus subtilis and its regulation.

Journal

J Bacteriol 189:187-97 (2007)
DOI:10.1128/JB.01273-06

Sequence

[bsu:BSU27260]

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.134

IUBMB Enzyme Nomenclature:

2.5.1.134

ExPASy - ENZYME nomenclature database:

2.5.1.134

BRENDA, the Enzyme Database:

2.5.1.134

DBGET integrated database retrieval system