KEGG ENZYME: 2.5.1.135

ENZYME: 2.5.1.135

Entry

EC 2.5.1.135                Enzyme

Name

validamine 7-phosphate valienyltransferase;
vldE (gene name);
valL (gene name)

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

GDP-valienol:validamine 7-phosphate valienyltransferase

Reaction(IUBMB)

GDP-valienol + validamine 7-phosphate = validoxylamine A 7'-phosphate + GDP [RN:R11497]

Reaction(KEGG)

R11497 > R11239;
(other) R11250

Substrate

GDP-valienol [CPD:C21368];
validamine 7-phosphate [CPD:C21216]

Product

validoxylamine A 7'-phosphate [CPD:C21219];
GDP [CPD:C00035]

Comment

The enzyme, characterized from several Streptomyces strains, is involved in the biosynthesis of the antifungal agent validamycin A.

History

EC 2.5.1.135 created 2016

Pathway

ec00525

Acarbose and validamycin biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K20436

validamine 7-phosphate valienyltransferase

Genes

SUR:	STAUR_3137

SHY:

SHJG_0274

SHO:	SHJGH_0108

SALS:

SLNWT_0581

SCYA:

EJ357_02040

SNQ:	CP978_00060

ACTQ:

OG417_31645

APRE:

CNX65_09975

AMI:

Amir_1997

CROS:

N8J89_05660

UME:	RM788_17705

» show all

Reference

1 [PMID:21766819]

Authors

Asamizu S, Yang J, Almabruk KH, Mahmud T

Title

Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.

Journal

J Am Chem Soc 133:12124-35 (2011)
DOI:10.1021/ja203574u

Reference

2 [PMID:22384130]

Authors

Zheng L, Zhou X, Zhang H, Ji X, Li L, Huang L, Bai L, Zhang H

Title

Structural and functional analysis of validoxylamine A 7'-phosphate synthase ValL involved in validamycin A biosynthesis.

Journal

PLoS One 7:e32033 (2012)
DOI:10.1371/journal.pone.0032033

Sequence

[shy:SHJG_0274]

Reference

3 [PMID:23028689]

Authors

Cavalier MC, Yim YS, Asamizu S, Neau D, Almabruk KH, Mahmud T, Lee YH

Title

Mechanistic insights into validoxylamine A 7'-phosphate synthesis by VldE using the structure of the entire product complex.

Journal

PLoS One 7:e44934 (2012)
DOI:10.1371/journal.pone.0044934

Sequence

[shy:SHJG_0274]

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.135

IUBMB Enzyme Nomenclature:

2.5.1.135

ExPASy - ENZYME nomenclature database:

2.5.1.135

BRENDA, the Enzyme Database:

2.5.1.135

DBGET integrated database retrieval system