KEGG   ENZYME: 2.5.1.139
Entry
EC 2.5.1.139                Enzyme                                 
Name
umbelliferone 6-dimethylallyltransferase;
PcPT;
dimethylallyl-diphosphate:umbelliferone 6-dimethylallyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
prenyl-diphosphate:umbelliferone 6-prenyltransferase
Reaction(IUBMB)
prenyl diphosphate + umbelliferone = diphosphate + demethylsuberosin [RN:R08996]
Reaction(KEGG)
R08996 > R09000
Substrate
prenyl diphosphate [CPD:C00235];
umbelliferone [CPD:C09315]
Product
diphosphate [CPD:C00013];
demethylsuberosin [CPD:C18083]
Comment
The enzyme from parsley (Petroselinum crispum) is specific for umbelliferone and prenyl diphosphate. A minor product is osthenol, which is produced by transfer of the prenyl group to C-8 of umbelliferone.
History
EC 2.5.1.139 created 2017
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01110  Biosynthesis of secondary metabolites
Orthology
K21588  umbelliferone 6-dimethylallyltransferase
Reference
1  [PMID:1366425]
  Authors
Hamerski D, Schmitt D, Matern U
  Title
Induction of two prenyltransferases for the accumulation of coumarin phytoalexins in elicitor-treated Ammi majus cell suspension cultures.
  Journal
Phytochemistry 29:1131-5 (1990)
DOI:10.1016/0031-9422(90)85417-E
Reference
2  [PMID:24354545]
  Authors
Karamat F, Olry A, Munakata R, Koeduka T, Sugiyama A, Paris C, Hehn A, Bourgaud F, Yazaki K
  Title
A coumarin-specific prenyltransferase catalyzes the crucial biosynthetic reaction for furanocoumarin formation in parsley.
  Journal
Plant J 77:627-38 (2014)
DOI:10.1111/tpj.12409
  Sequence
[ag:BAO31627]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.139
IUBMB Enzyme Nomenclature: 2.5.1.139
ExPASy - ENZYME nomenclature database: 2.5.1.139
BRENDA, the Enzyme Database: 2.5.1.139

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (2)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (3)   
   InterPro (3)   
All databases (18)   

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