Entry
Name
nerylneryl diphosphate synthase;
CPT2;
dimethylallyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 3 isopentenyl units)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
prenyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate cistransferase (adding 3 units of 3-methylbut-3-en-1-yl)
Reaction(IUBMB)
prenyl diphosphate + 3 (3-methylbut-3-en-1-yl diphosphate) = 3 diphosphate + nerylneryl diphosphate [RN:
R11940 ];
(1a) prenyl diphosphate + 3-methylbut-3-en-1-yl diphosphate = diphosphate + neryl diphosphate [RN:
R01659 ];
(1b) neryl diphosphate + 3-methylbut-3-en-1-yl diphosphate = diphosphate + (2Z,6Z)-farnesyl diphosphate [RN:
R12638 ];
(1c) (2Z,6Z)-farnesyl diphosphate + 3-methylbut-3-en-1-yl diphosphate = diphosphate + nerylneryl diphosphate [RN:
R12639 ]
Reaction(KEGG)
Substrate
prenyl diphosphate [CPD:
C00235 ];
3-methylbut-3-en-1-yl diphosphate [CPD:
C00129 ];
neryl diphosphate [CPD:
C02569 ];
(2Z,6Z)-farnesyl diphosphate [CPD:
C19760 ]
Product
diphosphate [CPD:
C00013 ];
nerylneryl diphosphate [CPD:
C21784 ];
neryl diphosphate [CPD:
C02569 ];
(2Z,6Z)-farnesyl diphosphate [CPD:
C19760 ]
Comment
Isolated from the plant Solanum lycopersicum (tomato).
History
EC 2.5.1.142 created 2017
Orthology
K22423 nerylneryl diphosphate synthase
Genes
Taxonomy
Reference
Authors
Akhtar TA, Matsuba Y, Schauvinhold I, Yu G, Lees HA, Klein SE, Pichersky E
Title
The tomato cis-prenyltransferase gene family.
Journal
Sequence
Reference
Authors
Matsuba Y, Zi J, Jones AD, Peters RJ, Pichersky E
Title
Biosynthesis of the diterpenoid lycosantalonol via nerylneryl diphosphate in Solanum lycopersicum.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.5.1.142