Entry
Name
pyridinium-3,5-biscarboxylic acid mononucleotide synthase;
LarB;
P2CMN synthase;
nicotinic acid adenine dinucleotide carboxylase/hydrolase;
NaAD carboxylase/hydrolase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
deamido-NAD+:hydrogencarbonate nicotinate-beta-D-ribonucleotidyltransferase
Reaction(IUBMB)
deamido-NAD+ + hydrogencarbonate = AMP + pyridinium-3,5-biscarboxylate mononucleotide [RN:
R12017 ]
Reaction(KEGG)
Substrate
Product
AMP [CPD:
C00020 ];
pyridinium-3,5-biscarboxylate mononucleotide [CPD:
C21851 ]
Comment
This enzyme, found in the bacterium Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor. It carboxylates the pyridinium ring of deamido-NAD+ and cleaves the phosphoanhydride bond to release AMP and generate pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN).
History
EC 2.5.1.143 created 2018
Orthology
K06898 pyridinium-3,5-biscarboxylic acid mononucleotide synthase
Genes
CATE : C2869_06450 C2869_22205
GAI : IMCC3135_06245(purE_1)
MMES : MMSR116_17350(larB)
SINL : DSM14862_03980(larB)
SPSE : SULPSESMR1_03847(purE)
GEF : FO488_15690(larB) FO488_17535(larB)
GBN : GEOBRER4_19850 GEOBRER4_35260
DMS : E8L03_07260(larB) E8L03_08325(larB)
DTI : Desti_2447 Desti_5193
PCAL : BV455_03528(purE_2)
BAYD : BSPP4475_14720(larB)
COHN : KCTCHS21_48030(larB)
LNG : BSQ50_05840 BSQ50_10055
LHW : BSQ49_00450 BSQ49_08385
LGM : LG542_05680(larB) LG542_08130(larB)
EGV : EGCR1_11155(larB) EGCR1_12075(larB)
AMIT : DBT49_0001420(larB)
CLJ : CLJU_c02850 CLJU_c15580
CLS : CXIVA_14610 CXIVA_23140
CACE : CACET_c05400(purE2)
CCK : Ccar_12695 Ccar_21500
DOR : Desor_0620 Desor_2617 Desor_3246
ELM : ELI_0292 ELI_0451 ELI_1456
EMT : CPZ25_000630(larB) CPZ25_012240(larB) CPZ25_014825(larB)
ELIM : B2M23_01615 B2M23_04520 B2M23_11060
AWI : CHL1_002277(larB) CHL1_003437(larB)
BPRO : PMF13cell1_01771(purE_1)
BLUI : Blut17040_08410(larB)
CSCI : HDCHBGLK_00382(purE_1) HDCHBGLK_02443(purE_3) HDCHBGLK_02624
AMIJ : EQM06_00110(larB) EQM06_02740(larB)
AMIC : Ami3637_04085(larB)
ABUT : Ami103574_05255(larB)
ETM : CE91St48_13520(larB)
TTO : Thethe_00992 Thethe_01834
PIV : NCTC13079_01024(purE_2)
PCAT : Pcatena_02460(larB)
RTS : CE91St31_05390(larB)
SLE : sle_12220(sle_12220)
RAIN : Rai3103_03780(larB)
BROO : brsh051_07670(larB)
SYY : SYNGTS_3005(sll1489)
SYT : SYNGTI_3004(sll1489)
SYS : SYNPCCN_3003(sll1489)
SYQ : SYNPCCP_3003(sll1489)
SYR : SynRCC307_1733(cpmA)
SYX : SynWH7803_1721(cpmA)
SYNW : SynWH8103_01835(cpmA)
TVN : NIES2134_113260(cpmA)
PAGH : NIES204_07690(cpmA)
PRUN : PCC7821_03364(larB)
NSPH : BDGGKGIB_02082(larB)
ABIW : Abiwalacus_01460(larB)
AAGG : ETAA8_24500(purE_2)
AMUC : Pan181_06130(purE_1)
BMEI : Spa11_41060(purE_1)
SVP : Pan189_15750(purE_1)
PBOR : BSF38_04499(purE_1)
MSCH : N508_000576(larB) N508_001784
NMV : NITMOv2_0481 NITMOv2_2977
ALAM : RT761_02778(purE_2)
MVN : Mevan_0277 Mevan_0317
MMET : MCMEM_0415 MCMEM_1200
MOU : OU421_01385(larB) OU421_01705(larB)
HALA : Hrd1104_00880(larB)
HARC : HARCEL1_01835(larB)
HALQ : Hrr1229_007455(larB)
HACB : Hbl1158_01800(larB)
LOKI : Lokiarch_44260(purE_2)
PSYT : DSAG12_01935(purE_2)
» show all
Taxonomy
Reference
Authors
Desguin B, Soumillion P, Hols P, Hausinger RP
Title
Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.5.1.143