KEGG   ENZYME: 2.5.1.146
Entry
EC 2.5.1.146                Enzyme                                 
Name
3-geranyl-3-[(Z)-2-isocyanoethenyl]indole synthase;
famD2 (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
geranyl-diphosphate:3-[(Z)-2-isocyanoethenyl]-1H-indole geranyltransferase
Reaction(IUBMB)
geranyl diphosphate + 3-[(Z)-2-isocyanoethenyl]-1H-indole = 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate [RN:R12089]
Reaction(KEGG)
R12089
Substrate
geranyl diphosphate [CPD:C00341];
3-[(Z)-2-isocyanoethenyl]-1H-indole [CPD:C21893]
Product
3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole [CPD:C21837];
diphosphate [CPD:C00013]
Comment
The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, participates in the biosynthesis of hapalindole-type alkaloids.
History
EC 2.5.1.146 created 2018
Orthology
K22841  3-geranyl-3-[(Z)-2-isocyanoethenyl]indole synthase
Reference
1  [PMID:26629885]
  Authors
Li S, Lowell AN, Yu F, Raveh A, Newmister SA, Bair N, Schaub JM, Williams RM, Sherman DH
  Title
Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C-C Bond-Forming Cascade.
  Journal
J Am Chem Soc 137:15366-9 (2015)
DOI:10.1021/jacs.5b10136
  Sequence
[ag:APB62260]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.146
IUBMB Enzyme Nomenclature: 2.5.1.146
ExPASy - ENZYME nomenclature database: 2.5.1.146
BRENDA, the Enzyme Database: 2.5.1.146

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (8)   

Download RDF
DBGET integrated database retrieval system