KEGG ENZYME: 2.5.1.152

ENZYME: 2.5.1.152

Entry

EC 2.5.1.152                Enzyme

Name

D-histidine 2-aminobutanoyltransferase;
cntL (gene name)

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

S-adenosyl-L-methionine:D-histidine N-[(3S)-3-amino-3-carboxypropyl]-transferase

Reaction(IUBMB)

S-adenosyl-L-methionine + D-histidine = N-[(3S)-3-amino-3-carboxypropyl]-D-histidine + S-methyl-5'-thioadenosine [RN:R12341]

Reaction(KEGG)

R12341

Substrate

S-adenosyl-L-methionine [CPD:C00019];
D-histidine [CPD:C06419]

Product

N-[(3S)-3-amino-3-carboxypropyl]-D-histidine [CPD:C22025];
S-methyl-5'-thioadenosine [CPD:C00170]

Comment

The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt.

History

EC 2.5.1.152 created 2019

Pathway

ec00470

D-Amino acid metabolism

ec01100

Metabolic pathways

Orthology

K23120

histidine 2-aminobutanoyltransferase

Genes

YPE:

YPO1346

YPK:

y2836

YPH:

YPC_2841

YPA:

YPA_0632

YPN:

YPN_2638

YPM:	YP_1250(smtA3)

YPP:	YPDSF_2353

YPG:	YpAngola_A1576

YPZ:

YPZ3_1228

YPT:	A1122_18845

YPD:

YPD4_1191

YPX:

YPD8_0954

YPW:

CH59_496

YPJ:

CH55_1202

YPV:

BZ15_2208

YPL:

CH46_3783

YPS:

YPTB1372

YPO:

BZ17_1147

YPI:	YpsIP31758_2632

YPY:

YPK_2717

YPB:

YPTS_1471

YPQ:

DJ40_856

YPU:

BZ21_648

YPR:

BZ20_607

YPC:

BZ23_982

YPF:

BZ19_780

YSI:	BF17_15910

SMW:	SMWW4_v1c21340

SERF:

L085_18085

SERS:

SERRSCBI_09995

SSUR:

ATE40_007155

SURI:

J0X03_13345

SNEM:

NLX84_10755

SNEV:

OI978_22600

ANS:	ArsFIN_50690

VNI:	VIBNI_B0488

VAQ:	FIV01_17880

VNP:	KW548_09015

PAE:

PA4836

PAEV:

N297_5005

PAEI:

N296_5005

PAU:	PA14_63940

PAP:	PSPA7_5555

PAG:	PLES_52211

PAF:	PAM18_4947

PNC:	NCGM2_0693

PAEB:

NCGM1900_5574

PDK:	PADK2_25665

PSG:	G655_25510

PRP:	M062_25525

PAEP:

PA1S_26285

PAER:

PA1R_gp2757

PAEM:

U769_26540

PAEL:

T223_26735

PAES:

SCV20265_5494

PAEU:

BN889_05385

PAEG:

AI22_07715

PAEC:

M802_5003

PAEO:

M801_4870

PPAA:

B7D75_25165

THIS:

HZT40_09135

SDO:	SD1155_03780

SECH:

B18_11685

BSON:

S101395_03012

BHA:

BH2072

AND:	GRQ40_16005

LSP:

Bsph_1830

LFU:	HR49_17250

LYB:	C3943_14840

LMAC:

I6G82_11165

LYC:	FH508_0007340

FPN:	ABE65_005805

FAR:	ABE41_005930

PSYB:

KD050_07360

MEKU:

HUW50_21735

MDG:	K8L98_19850

SLMS:

MM221_10310

SA2257

SAV:

SAV2469

SAW:

SAHV_2453

SAH:	SaurJH1_2545

SAJ:	SaurJH9_2496

SAM:

MW2393

SAS:

SAS2360

SAR:

SAR2556

SAC:

SACOL2478

SAX:	USA300HOU_2460

SAA:	SAUSA300_2413

SAO:	SAOUHSC_02769

SAE:

NWMN_2366

SAD:

SAAV_2535

SUU:	M013TW_2429(cntL)

SUV:	SAVC_11215

SUE:	SAOV_2519c

SUJ:	SAA6159_02366(cntL)

SUK:	SAA6008_02510(fmrO)

SUC:	ECTR2_2326

SUT:	SAT0131_02668

SUQ:	HMPREF0772_10720

SUZ:

MS7_2482

SUD:	ST398NM01_2519

SUX:	SAEMRSA15_23670

SUW:	SATW20_25970

SUG:

SAPIG2519

SUF:	SARLGA251_22490

SAUA:

SAAG_00295

SAUE:

RSAU_002307

SAUN:

SAKOR_02453

SAUS:

SA40_2217

SAUU:

SA957_2301

SAUG:

SA268_2374

SAUZ:

SAZ172_2572

SAUT:

SAI1T1_2018390

SAUJ:

SAI2T2_1018400

SAUK:

SAI3T3_1018390

SAUQ:

SAI4T8_1018400

SAUV:

SAI7S6_1018390

SAUW:

SAI5S5_1018330

SAUX:

SAI6T6_1018330

SAUY:

SAI8T7_1018370

SAUF:

X998_2453

SAB:

SAB2352c

SUY:	SA2981_2406

SAUB:

C248_2519

SAUM:

BN843_25090

SAUC:

CA347_2548

SAUR:

SABB_01208

SAUI:

AZ30_12965

SAUD:

CH52_06640

SAMS:

NI36_12275

SUH:	SAMSHR1132_22940

SER:

SERP2374

SEP:

SE_0202

SEPP:

SEB_00130

SEPS:

DP17_1262

SSD:	SPSINT_0077

SDT:

SPSE_2400

SDP:	NCTC12225_02595

SWA:	A284_00415

SPAS:

STP1_1305

SXY:	BE24_11760

SXL:	SXYLSMQ121_0068

SXO:	SXYL_00069

SHU:	SHYC_11650

SSCH:

LH95_11155

SSCZ:

RN70_11905

SLZ:	B5P37_06430

SFQ:	C7J90_03770

SCAR:

DWB96_00445(cntL)

SCHR:

DWB92_11725(cntL)

SSH:	NCTC13712_02421

SLLO:

ISP08_00445(cntL)

SRAI:

LN051_10980(cntL)

SPSD:

JMB28_00740(cntL)

SEDA:

MNY58_00460(cntL)

SROT:

ML435_11880(cntL)

SFF:	FOB90_08235(cntL)

SSTE:

SAMEA4384403_1089

BBE:	BBR47_28210

BFM:	BP422_09280

BAGR:

BA6348_01050

BPAB:

PSE45_01830

GYM:	GYMC10_2836

PMS:	KNP414_01894

PMQ:	PM3016_2179

PMW:

B2K_11200

PAEA:

R70723_16825

PNP:	IJ22_25000

PVO:	PVOR_17334

PLW:	D5F53_15605

PCHI:

PC41400_19305 PC41400_19395

PPRT:

ET464_05575

PBAC:

HUB98_11425

PLYC:

GXP70_07675

PTRI:

KDC22_17090

PALO:

E6C60_2223

PUI:	PUW25_11735

PAMY:

P9222_12195

PNK:	AASFL403_06945

PPAB:

KET34_28290

PKP:	SK3146_02468

COHN:

KCTCHS21_30100

PANA:

BBH88_13390

CFM:	BJL90_00605

CARG:

RSJ17_16760

HHW:	NCTC503_01797

VPY:	HZI73_24755

AMT:

Amet_2051

GPD:	GII33_20955

AAI:	AARI_10890

GAR:	AOZ07_05770

GLU:	F0M17_05430

GNC:	QQS42_05445

PAEY:

KUF55_05515

APRE:

CNX65_19685

AMI:

Amir_3919

UME:	RM788_04615

PLK:	CIK06_26260

FNT:	HMPREF0405_01275

FNE:	FSDG_01138

FVA:	FV113G1_15610

FUL:	C4N20_14595

FMO:	C4N19_08460

» show all

Reference

1 [PMID:27230378]

Authors

Ghssein G, Brutesco C, Ouerdane L, Fojcik C, Izaute A, Wang S, Hajjar C, Lobinski R, Lemaire D, Richaud P, Voulhoux R, Espaillat A, Cava F, Pignol D, Borezee-Durant E, Arnoux P

Title

Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus.

Journal

Science 352:1105-9 (2016)
DOI:10.1126/science.aaf1018

Sequence

[sav:SAV2469]

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.152

IUBMB Enzyme Nomenclature:

2.5.1.152

ExPASy - ENZYME nomenclature database:

2.5.1.152

BRENDA, the Enzyme Database:

2.5.1.152

DBGET integrated database retrieval system