KEGG   ENZYME: 2.5.1.156
Entry
EC 2.5.1.156                Enzyme                                 
Name
geranylfarnesylglycerol-phosphate geranylfarnesyltransferase;
DGFGP synthase;
2,3-bis-O-(farnesylgeranyl)-sn-glycerol 1-phosphate synthase;
2,3-di-O-farnesylgeranylglyceryl synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
all-trans-pentaprenyl diphosphate:sn-3-O-(pentaprenyl)glycerol 1-phosphate pentaprenyltransferase
Reaction(IUBMB)
all-trans-pentaprenyl diphosphate + sn-3-O-(farnesylgeranyl)glycerol 1-phosphate = 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate [RN:R13007]
Reaction(KEGG)
R13007
Substrate
all-trans-pentaprenyl diphosphate [CPD:C04217];
sn-3-O-(farnesylgeranyl)glycerol 1-phosphate [CPD:C22513]
Product
2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate [CPD:C22514];
diphosphate [CPD:C00013]
Comment
The enzyme, characterized from the archaeon Aeropyrum pernix, carries out the second prenyltransfer reaction involved in the formation of C25,C25 membrane diether-lipids in some archaea. Requires a divalent metal cation, such as Mg2+. The enzyme cannot accept sn-3-(O-geranylgeranyl)glycerol 1-phosphate as the prenyl donor. cf. EC 2.5.1.42, geranylgeranylglycerol-phosphate geranylgeranyltransferase.
History
EC 2.5.1.156 created 2022
Orthology
K25921  geranylfarnesylglycerol-phosphate geranylfarnesyltransferase
Genes
APEAPE_0159
ACJACAM_0126
Reference
1  [PMID:29427665]
  Authors
Yoshida R, Yoshimura T, Hemmi H.
  Title
Biosynthetic machinery for C25,C25-diether archaeal lipids from the hyperthermophilic archaeon Aeropyrum pernix.
  Journal
Biochem Biophys Res Commun 497:87-92 (2018)
DOI:10.1016/j.bbrc.2018.02.028
  Sequence
[ape:APE_0159]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.156
IUBMB Enzyme Nomenclature: 2.5.1.156
ExPASy - ENZYME nomenclature database: 2.5.1.156
BRENDA, the Enzyme Database: 2.5.1.156

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