rRNA small subunit aminocarboxypropyltransferase;
TSR3 (gene name)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
S-adenosyl-L-methionine + an N1-methylpseudouridine in rRNA = S-methyl-5'-thioadenosine + an N1-methyl-N3-[(3S)-3-aminocarboxypropyl]-pseudouridine in rRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
N1-methylpseudouridine in rRNA
Product
S-methyl-5'-thioadenosine [CPD:C00170];
N1-methyl-N3-[(3S)-3-aminocarboxypropyl]-pseudouridine in rRNA
Comment
The enzyme, found in all eukaryotes and some archaea, catalyses the final step in production of the modified rRNA nucleotide N1-methyl-N3-[(3S)-aminocarboxypropyl]-pseudouridine (m1acp3psi). This modified nucleotide is present in the small subunit of ribosomal RNA (18S in eukaryotes and 16S in archaea). cf. EC 2.5.1.114, tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase, and EC 2.5.1.108, 2-(3-amino-3-carboxypropyl)histidine synthase.
