Entry
Name
thiamine pyridinylase;
pyrimidine transferase;
thiaminase I;
thiamin hydrolase;
thiamin pyridinolase;
thiaminase (ambiguous);
thiamine pyridinolase;
thiamin pyridinylase;
thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase
Reaction(IUBMB)
thiamine + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole [RN:
R02863 ]
Reaction(KEGG)
Substrate
Product
1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium [CPD:
C02691 ];
4-methyl-5-(2-hydroxyethyl)thiazole [CPD:
C04294 ]
Comment
Various bases and thiol compounds can act instead of pyridine.
History
EC 2.5.1.2 created 1961, modified 1976, modified 2001
Pathway
Orthology
Genes
SUR : STAUR_1070 STAUR_5800
AVM : JQX13_02355 JQX13_08095
PNK : AASFL403_15660(bcmE)
AER : AERYTH_06055 AERYTH_16485
» show all
Taxonomy
Reference
Authors
FUJITA A.
Title
Thiaminase.
Journal
Reference
Authors
KENTEN RH.
Title
[Pteridium aquilinum (L.) Kuhn.]
Journal
Reference
Authors
Wittliff JL, Airth RL.
Title
The extracellular thiaminase I of Bacillus thiaminolyticus. I. Purification and physicochemical properties.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.2
ExPASy - ENZYME nomenclature database: 2.5.1.2
BRENDA, the Enzyme Database: 2.5.1.2