Entry
Name
N-acylneuraminate-9-phosphate synthase;
N-acetylneuraminate 9-phosphate lyase;
N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase;
N-acetylneuraminate 9-phosphate synthetase;
N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating);
sialic acid 9-phosphate synthetase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase
Reaction(IUBMB)
phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O = N-acylneuraminate 9-phosphate + phosphate [RN:
R02769 ]
Reaction(KEGG)
Substrate
phosphoenolpyruvate [CPD:
C00074 ];
N-acyl-D-mannosamine 6-phosphate [CPD:
C00686 ];
H2O [CPD:
C00001 ]
Product
N-acylneuraminate 9-phosphate [CPD:
C01200 ];
phosphate [CPD:
C00009 ]
Comment
Acts on N-glycoloyl and N-acetyl-derivatives.
History
EC 2.5.1.57 created 1972 as EC 4.1.3.20, transferred 2002 to EC 2.5.1.57
Pathway
ec00520 Amino sugar and nucleotide sugar metabolism
Orthology
Genes
TPAI : 128089605 128089615
LMUT : 125687047 125687392
XLA : 432051(nans.S) 447417(nans.L)
DRE : 322780(nansa) 492779(nansb)
SRX : 107723182 107754352 107754390 107758866
SANH : 107665955 107686966 107686967 107692601
SGH : 107557947 107566238 107566239
CCAR : 109076464 109090623 109090659
CAUA : 113044320 113066551 113066555 113066556 113066635 113085422 113105679
CGIB : 127946856 127946857 127948763 127975766
LROH : 127156361(nansb) 127172436(nansa)
OMC : 131524664 131534998(nansb) 131541588(nansa)
PPRM : 120475377(nansb) 120475384 120475385 120475386 120478311(nansa)
RKG : 130097610 130097653 130106509 130106510
MAMB : 125247499 125247713 125247908 125247921 125248041 125251616 125251645 125272478(nansa)
CIDE : 127507296 127519832
MASI : 127443667 127445253
TDW : 130407907(nansa) 130414328 130414329 130414351 130414352 130414355 130414375
MANU : 129433135 129433751 129444857(nansa) 129445965
IPU : 100528493(nansa) 108260162
IFU : 128603812 128604222(nansa)
SMEO : 124378730 124381237(nansa)
CMAO : 118811935 118811936 118816978(nansa)
EEE : 113568448(nans) 113589926
CGOB : 115010173 115010214
PGEO : 117439291(nansa) 117450755
GACU : 117555257 117561263(nansa) 117561638
AFB : 129095925 129096028(nansa)
MSAM : 119884880 119899378 119899379
SCHU : 122873785 122873786
CUD : 121507902 121508708 121508709
ONL : 100695579 100695847 100696106
OAU : 116310552 116310553 116310587
PRET : 103467988(nans) 103472627
CVG : 107083396(nans) 107083415 107083416
CTUL : 119787144 119787154 119787177
MCEP : 125003896 125004087 125004788
CSEM : 103384124 103384125
SSEN : 122770577 122771631
HHIP : 117769790 117769798
SMAU : 118312620 118312971
SSCV : 125969199 125969200
SBIA : 133506019 133506020
PTAO : 133476244 133476245
BPEC : 110166192 110166235
BSPL : 114858266 114858277 114858282
SASA : 100195066(sias) 106594767 106609889
STRU : 115191851 115202178 115202179 115202180 115202181
OMY : 110497423 110497424 110534455
OGO : 124001941 124001943 124012735
ONE : 115137363 115137722 115145762 115146546
OKE : 118362993 118362994 118395463
SALP : 111971593 112068285 112080022
SNH : 120034903 120051990 120052901
CCLU : 121534521 121535761 121535762
PSEX : 120532357 120532358 120532359
CMK : 103177631(nansa) 103177633
CPLA : 122539555(nansa) 122547124
BBEL : 109471483 109471485
DSI : Dsimw501_GD18832(Dsim_GD18832)
APLN : 108741788 112904754
PMAC : 106708951 106709065
PPOT : 106100777 106100789
PPOI : 119112814 119113236
ABRU : 129958113 129958114 129958115
EHX : EMIHUDRAFT_437804(NEUB)
HEBR : AEBR_0577 AEBR_2874
PSEL : GM415_02085 GM415_02270
PCLR : PC1C4_16490 PC1C4_23910
PRN : BW723_03025 BW723_09690
» show all
Taxonomy
Reference
Authors
ROSEMAN S, JOURDIAN GW, WATSON D, ROOD R.
Title
Enzymatic synthesis of sialic acid 9-phosphates.
Journal
Reference
Authors
Watson DR, Jourdian GW, Roseman S.
Title
The sialic acids. 8. Sialic acid 9-phosphate synthetase.
Journal
J Biol Chem 241:5627-36 (1966)
Reference
Authors
Nakata D, Close BE, Colley KJ, Matsuda T, Kitajima K
Title
Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.57
ExPASy - ENZYME nomenclature database: 2.5.1.57