KEGG ENZYME: 2.5.1.63

ENZYME: 2.5.1.63

Entry

EC 2.5.1.63                 Enzyme

Name

adenosyl-fluoride synthase;
fluorinase

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

S-adenosyl-L-methionine:fluoride adenosyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine [RN:R09637]

Reaction(KEGG)

R09637

Substrate

S-adenosyl-L-methionine [CPD:C00019];
fluoride [CPD:C00742]

Product

5'-deoxy-5'-fluoroadenosine [CPD:C19766];
L-methionine [CPD:C00073]

History

EC 2.5.1.63 created 2003

Orthology

K09134

adenosyl-fluoride synthase

Genes

NBR:	O3I_021605

SCT:	SCAT_4165(flA)

SCY:	SCATT_41540

ACTQ:

OG417_15765

ACTN:

L083_1819

Reference

1 [PMID:11907567]

Authors

O'Hagan D, Schaffrath C, Cobb SL, Hamilton JT, Murphy CD.

Title

Biochemistry: biosynthesis of an organofluorine molecule.

Journal

Nature 416:279 (2002)
DOI:10.1038/416279a

Reference

2 [PMID:14765200]

Authors

Dong C, Huang F, Deng H, Schaffrath C, Spencer JB, O'Hagan D, Naismith JH

Title

Crystal structure and mechanism of a bacterial fluorinating enzyme.

Journal

Nature 427:561-5 (2004)
DOI:10.1038/nature02280

Sequence

[sct:SCAT_4165]

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.63

IUBMB Enzyme Nomenclature:

2.5.1.63

ExPASy - ENZYME nomenclature database:

2.5.1.63

BRENDA, the Enzyme Database:

2.5.1.63

CAS:	438583-16-5

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