KEGG ENZYME: 2.5.1.68

ENZYME: 2.5.1.68

Entry

EC 2.5.1.68                 Enzyme

Name

(2Z,6E)-farnesyl diphosphate synthase;
(Z)-farnesyl diphosphate synthase;
Z-farnesyl diphosphate synthase

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase

Reaction(IUBMB)

geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2Z,6E)-farnesyl diphosphate [RN:R08528]

Reaction(KEGG)

R08528

Substrate

geranyl diphosphate [CPD:C00341];
isopentenyl diphosphate [CPD:C00129]

Product

diphosphate [CPD:C00013];
(2Z,6E)-farnesyl diphosphate [CPD:C16826]

Comment

Requires Mg2+ or Mn2+ for activity. The product of this reaction is an intermediate in the synthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of most features of the mycobacterial cell wall, including peptidoglycan, linker unit galactan and arabinan. Neryl diphosphate can also act as substrate.

History

EC 2.5.1.68 created 2007, modified 2010

Pathway

ec00900

Terpenoid backbone biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K12503

short-chain Z-isoprenyl diphosphate synthase

Genes

MMEO:

OOT43_11435(uppS)

BCJ:	BCAM2067(uppS)

BCEO:

I35_5903(uppS)

BCED:

DM42_5933(uppS)

BCEP:

APZ15_28620

BDL:	AK34_3632(uppS)

BCON:

NL30_01965

BSEM:

WJ12_30400

BMEC:

WJ16_28400 WJ16_28955

REL:	REMIM1_PE00482

HDT:	HYPDE_40383

ACR:

Acry_2740

AMV:	ACMV_30690(uppS)

ERZ:	ER308_17265(uppS)

EUZ:	DVS28_a3886

MTU:

Rv1086

MTV:

RVBD_1086

MTC:	MT1118(uppS-1)

MRA:

MRA_1096

MTF:	TBFG_11104

MTB:	TBMG_02901

MTK:	TBSG_02917

MTZ:	TBXG_002881

MTG:	MRGA327_06775

MTI:	MRGA423_06785

MTE:	CCDC5079_1003

MTUR:

CFBS_1149

MTL:	CCDC5180_0995

MTO:	MTCTRI2_1114

MTD:

UDA_1086

MTN:	ERDMAN_1212

MTJ:	J112_05860

MTUB:

MT7199_1111

MTUC:

J113_07610

MTUE:

J114_05860

MTX:	M943_05720

MTUL:

TBHG_01069

MTUT:

HKBT1_1148

MTUU:

HKBT2_1153

MTQ:	HKBS1_1150

MBO:	BQ2027_MB1115

MBB:

BCG_1144

MBT:

JTY_1117

MBM:	BCGMEX_1116

MBK:	K60_011660

MBX:

BCGT_0905

MAF:

MAF_10990

MMIC:

RN08_1217

MCE:	MCAN_10931

MCQ:	BN44_11204

MCV:	BN43_30140

MCX:	BN42_20935

MCZ:	BN45_30130

MORY:

MO_001166

MLE:

ML2467

MLB:

MLBr02467

MPA:

MAP_2703c

MAO:

MAP4_1113

MAVI:

RC58_05530

MAVU:

RE97_05525

MAV:

MAV_1211

MIT:

OCO_11180

MIA:

OCU_11160

MID:

MIP_01801

MYO:

OEM_11290

MCHI:

AN480_06670

MIR:

OCQ_11190

MMAL:

CKJ54_05435

MLP:

MLM_1159

MMAN:

MMAN_54430

MSA:	Mycsm_05073

MUL:	MUL_0193(uppS)

MMI:	MMAR_4380(uppS)

MMAE:

MMARE11_42000(uppS)

MLI:	MULP_04595(uppS_1)

MPSE:

MPSD_45230

MSHO:

MSHO_01530

MMC:	Mmcs_3583 Mmcs_4137

MKM:	Mkms_3656 Mkms_4212

MJL:	Mjls_3588 Mjls_4368

MMM:

W7S_05465

MKN:	MKAN_08090

MYV:	G155_22890

MYE:	AB431_06310

MHAD:

B586_07025

MDX:	BTO20_08215

MSHG:

MSG_03938

MFJ:	MFLOJ_47280

MSTO:

MSTO_51240

MSIM:

MSIM_37210

MSAK:

MSAS_22390

MKU:	I2456_20705

MLW:	MJO58_21515

MXE:	MYXE_13840

MNV:	MNVI_06330

MPAG:

C0J29_24140

MNM:	MNVM_08040

MGOR:

H0P51_22325

MCOO:

MCOO_20550

MBAI:

MB901379_03837

MSEO:

MSEO_27160

MHEK:

JMUB5695_01328

MGAU:

MGALJ_31440

MLJ:	MLAC_06470

MBRD:

MBRA_27160

MSHJ:

MSHI_02870

MMAM:

K3U93_19090

MSPG:

F6B93_17535

MOT:	LTS72_03280

MLM:

MLPF_0392

MPAA:

MKK62_05640

MMEH:

M5I08_20625

MKY:	IWGMT90018_50470

MADI:

A7U43_09230

MWU:	PT015_11865

MSM:	MSMEG_5256(uppS)

MSG:	MSMEI_5118

MSB:	LJ00_25995

MSN:	LI99_26000

MSH:	LI98_26005

MVA:	Mvan_1705 Mvan_4662

MGI:

Mflv_2055

MSP:	Mspyr1_14790 Mspyr1_40870

MCB:	Mycch_1318 Mycch_4074

MNE:	D174_21505

MYN:	MyAD_21090

MFT:	XA26_46950

MPHL:

MPHLCCUG_04253(uppS_2)

MVQ:	MYVA_1453 MYVA_4488(uppS)

MLL:	B1R94_06285

MRH:	MycrhN_3527

MTHN:

4412656_03573

MHAS:

MHAS_03234(uppS_2)

MDU:	MDUV_00450

MCHT:

MCHIJ_25230(uppS_1)

MDR:	MDOR_29050(uppS_2)

MAUU:

NCTC10437_04387

MMAG:

MMAD_42910

MMOR:

MMOR_18100(uppS_1)

MFX:	MFAL_37750(uppS_2)

MAIC:

MAIC_44070(uppS_2)

MIJ:	MINS_38630

MALV:

MALV_48250(uppS_2)

MTY:	MTOK_05330

MPSC:

MPSYJ_21920(uppS_1)

MARZ:

MARA_54130(uppS_1)

MGAD:

MGAD_29790

MHEV:

MHEL_10310

MSAR:

MSAR_26730

MANY:

MANY_27180(uppS_2)

MAUB:

MAUB_43280(uppS_1)

MPOF:

MPOR_47260

MPHU:

MPHO_26180(uppS_2)

MMUC:

C1S78_005255

MMAT:

MMAGJ_05950(uppS_1)

MBOK:

MBOE_26960(uppS_1)

MFG:	K6L26_08880

MSEI:

MSEDJ_55180(uppS_2)

MFLV:

NCTC10271_01083

MCEE:

MCEL_43870(uppS_2)

MBRM:

L2Z93_000799

MMON:

EWR22_22395

MGO:	AFA91_14345

MHOL:

K3U96_05870

MSEN:

K3U95_21980

MPAE:

K0O64_05890

MRF:	MJO55_21095

MDF:	K0O62_22515

MCRO:

MI149_06600

MGRO:

FZ046_26490

MKR:	MKOR_40270(uppS_2)

MPAK:

MIU77_04140

MAB:

MAB_1209

MMV:	MYCMA_0646

MABB:

MASS_1207

MABL:

MMASJCM_1236

MCHE:

BB28_06000

MIZ:	BAB75_06590

MSTE:

MSTE_01175

MSAO:

MYCSP_05335

MSAL:

DSM43276_01075(uppS_1)

MJD:	JDM601_1033(uppS)

MTER:

4434518_01019(uppS_1)

MMIN:

MMIN_26790

MHIB:

MHIB_05940

MHER:

K3U94_05800

MVM:	MJO54_05930

ASD:

AS9A_3411

CGL:	Cgl0991(Cgl0991)

CGB:	cg1130(uppS1)

CGU:	WA5_0951(UppS1)

CGT:

cgR_1084

CGS:	C624_05775

CGG:	C629_05775

CGM:	cgp_1130(uppS1)

CGJ:

AR0_05470

CGQ:	CGLAR1_05335

CGX:	SB89_05200

CEF:

CE1055

CDI:

DIP0929

CDP:	CD241_0835(uppS1)

CDH:	CDB402_0808(uppS1)

CDT:	CDHC01_0836(uppS1)

CDE:	CDHC02_0835(uppS1)

CDR:	CDHC03_0833(uppS1)

CDA:	CDHC04_0844(uppS1)

CDZ:	CD31A_0933(uppS1)

CDB:	CDBH8_0880(uppS1)

CDS:	CDC7B_0844(uppS1)

CDD:	CDCE8392_0836(uppS1)

CDW:	CDPW8_0895(uppS1)

CDV:	CDVA01_0802(uppS1)

CDIP:

ERS451417_00833(uppS1)

CJK:	jk1467(uppS1)

CUR:

cu0602

CUA:	CU7111_0594(uppS1)

CAR:	cauri_0927(uppS1)

CKP:	ckrop_0567

CPU:	CPFRC_03645

CPL:	Cp3995_0737(uppS1)

CPG:	CP316_03780

CPP:	CpP54B96_0736(uppS1)

CPK:	CP1002_09490

CPQ:	CPC231_03645

CPX:	CPI19_07875

CPZ:	CpPAT10_0723(uppS1)

COR:	Cp267_0759(uppS1)

COP:	CP31_04010

COD:	Cp106_0709(uppS1)

COS:	Cp4202_0715(uppS1)

COI:	CPCIP5297_03800

COE:	CP258_03795

COU:	CP162_03700

CPSE:

CPTA_01279

CPSU:

CPTB_00253

CPSF:

CPTC_01271

CRD:	CRES_1604(uppS1)

CUL:	CULC22_00784

CUC:	CULC809_00769

CUE:	CULC0102_0880

CUN:	Cul210932_0809(uppS1)

CUQ:	Cul210931_0773(uppS1)

CUZ:	Cul05146_0831(uppS1)

CUJ:	CUL131002_0787(uppS1)

CUS:	CulFRC11_0776(uppS1)

CVA:

CVAR_1939

CHN:	A605_04935

CCN:	H924_04660

CTER:

A606_07885

CMD:	B841_04540

CAZ:	CARG_03420

CFN:	CFAL_08165

CCG:	CCASEI_09605

CVT:	B843_04985

CGY:	CGLY_06150(uppS1)

CAX:	CATYP_03660

CII:	CIMIT_03975

CUV:	CUREI_04195

COA:	DR71_505(uppS)

CDO:	CDOO_04830

CHM:	B842_04400

CSX:	CSING_05100(uppS1)

CMQ:	B840_03885(uppS1)

CKU:	UL82_08070(uppS1)

CCJ:	UL81_04280(uppS1)

CMV:	CMUST_05540(uppS1)

CEI:	CEPID_04395(uppS1)

CTED:

CTEST_04345(uppS1)

CUT:	CUTER_03825(uppS1)

CLW:	CLAC_08905

CDX:	CDES_04840(uppS1)

CSP:

WM42_0450

CSTA:

CSTAT_08860

CCJZ:

ccrud_04875

CFK:	CFRA_04010

CPHO:

CPHO_08120

CFC:	CFLV_04595

CGV:	CGLAU_04350(uppS)

CSTR:

CBE89_08970

CAQU:

CAQU_04415

CSPH:

CSPHI_08995

CAMG:

CAMM_08980

CMIN:

NCTC10288_01619(uppS1)

CPEG:

CPELA_07235(uppS2)

CXE:	FOB82_02020

CEE:	CENDO_04125(uppS)

CSAN:

E3227_11390

CGK:	CGERO_03940(uppS)

CRF:	FRC0190_00887

CRL:	NCTC7448_01598(uppS1)

CCHO:

CCHOA_03760(uppS)

CPRE:

Csp1_09510(uppS)

CPSO:

CPPEL_07475(uppS2)

CSUR:

N24_1112(uppS1)

CCYS:

SAMEA4530656_1505

CMAT:

HBA49_11170

CYZ:	C3B44_07555

CKF:	I6I12_08505

CANS:

GP473_06490

CLIA:

C3E79_03890

CPRP:

I6I69_09525

CAMC:

I6I65_04800

CGLU:

I6J20_05610

CUO:	CUROG_07305

CLIZ:

G7Y31_04060

CSIL:

CBE74_04440

CTUB:

I6I74_09375

CLUJ:

IAU68_03995

CQN:	G7Y29_03670

CKW:	CKALI_07985

CCOE:

CETAM_04260(uppS)

COK:	COCCU_04635(uppS)

CZO:	IAU67_06600

CCYC:

SCMU_12490

CORY:

FQV43_03245

CMF:	GWO64_007920

CWK:	IA203_04480

CUW:	LH390_03880

CPOY:

GP475_04255

CACC:

CACC_04610

CFY:	I6L56_05300

CPSL:

KBP54_04030

CHIN:

J5O04_05875

CJH:	CJEDD_04225(uppS)

CPSP:

L9H27_03875

CMAS:

CMASS_03745

CHEI:

CHEID_07665

CIHU:

CIHUM_04015(uppS)

CCOY:

CCOY_04530(uppS)

CHAD:

CHAD_04290(uppS)

CFG:	CFREI_04460(uppS)

CAQM:

CAQUA_07705(uppS)

CCAW:

CCANI_04670

CAUI:

CAURIS_03980(uppS)

CFAC:

CFAEC_04390(uppS1)

CFOU:

CFOUR_03950(uppS)

CFEU:

CFELI_04440(uppS1)

CAUS:

CAURIC_07800(uppS)

CATR:

CATRI_04160(uppS1)

CDUR:

CDUR_04455(uppS)

CCOU:

CCONF_04300(uppS)

CHAN:

CHAN_10125(uppS)

CAFE:

CAFEL_03815(uppS)

CGF:	CGUA_04540(uppS)

CGOI:

CGOTT_04045(uppS)

CAPP:

CAPP_03920(uppS)

CBOV:

CBOVI_03490(uppS)

CBRE:

QP027_03645

CPYR:

CYJ47_08235

CRIE:

AK829_05555

BFV:	C628_05430

NFA:

NFA_48180

NFR:	ERS450000_05097

NCY:	NOCYR_4592(uppS)

NBR:	O3I_036355

NNO:	NONO_c65530(uppS1)

NSL:	BOX37_25865

NSR:	NS506_01820

NTP:	CRH09_34060

NOZ:	DMB37_15005 DMB37_28775

NOD:	FOH10_02440

NAH:	F5544_38445

NAD:	NCTC11293_06158

NWL:	NWFMUON74_11170 NWFMUON74_46050(uppS_1)

NIE:	KV110_35440

NTC:	KHQ06_11745

NHU:	H0264_11045

NYA:	LTV02_21720

NGP:	LTT66_18590

NSPU:

IFM12276_06990

NYU:	D7D52_01685

RHA:	RHA1_ro05856

RER:

RER_42550

REY:

O5Y_19910

REB:	XU06_20065

RQI:	C1M55_20990

ROP:

ROP_59180

ROA:	Pd630_LPD02483

RPY:	Y013_21855

RBY:	CEJ39_08320

RHB:

NY08_4949

RAV:	AAT18_07735

RFA:	A3L23_03008(uppS)

RHS:	A3Q41_00315(uppS)

RHW:	BFN03_02175

RRZ:	CS378_22740

RHU:	A3Q40_02392(uppS)

RHQ:	IM25_11610

RHOD:

AOT96_01430

RRT:	4535765_01169

RCR:	NCTC10994_01569

RTM:	G4H71_04280

RKO:	JWS14_32015

RGO:	KYT97_28400

ROZ:	CBI38_22035

RPSK:

JWS13_11895

RGOR:

NMQ04_05335

RANT:

RHODO2019_12775

RHOP:

D8W71_24360

REQ:

REQ_12990

PDEF:

P9209_25610

WHR:	OG579_20780

GBR:

Gbro_1657

GPO:	GPOL_c15400

GOR:

KTR9_1618

GOQ:	ACH46_05330

GTA:	BCM27_08640

GOC:	CXX93_16650

GIT:	C6V83_06155

GRU:	GCWB2_08165(uppS)

GOM:	D7316_01581(uppS)

GAV:	C5O27_19645

GOD:	GKZ92_07725

GAM:	GII34_07155

GPD:	GII33_06580 GII33_06810 GII33_06855(uppS) GII33_06870

GJI:	H1R19_07970

GOI:	LK459_02410

GHN:	MVF96_08080

GAMI:

IHQ52_10985

GMG:	NWF22_18610

GSI:	P5P27_04225

SPIN:

KV203_14030

TPR:

Tpau_3135

TSM:	ASU32_05850

TPUL:

TPB0596_35840

TSD:	MTP03_10810

SRT:

Srot_1973

DTM:	BJL86_2133

DIT:	C3V38_00425

DIZ:	CT688_10460

DPC:	A6048_10645

DLU:	A6035_10160

DKN:	NHB83_10040

CBQ:	AL705_01930

TOY:	FO059_07040

SCO:	SCO3858(SCH69.28c)

SALB:

XNR_4115

SMA:	SAVERM_3237(uppS1)

SGR:	SGR_1991 SGR_2506

SGB:	WQO_22915 WQO_25515

SFI:	SFUL_4823 SFUL_5373

SANL:

KZO11_24220 KZO11_27040

SGRF:

SGFS_045600 SGFS_084480

SCYE:

R2B67_08800 R2B67_11685

SCB:	SCAB_33671(uppS1)

SSX:	SACTE_4279

SVL:	Strvi_1338

SHY:

SHJG_6124

SHO:	SHJGH_5886

SRC:	M271_18845

SMAL:

SMALA_4868

SSOI:

I1A49_28475

SFA:

Sfla_2240

SBH:

SBI_04188

SVE:

SVEN_4694

SDV:	BN159_3370(uppS1) BN159_7965(uppS2)

SALS:

SLNWT_4995

STRP:

F750_4567

SCI:	B446_23520

SLV:	SLIV_18980(uppS2)

SGU:	SGLAU_21635(uppS)

SVT:	SVTN_24425

STRE:

GZL_03653

SCW:	TU94_20960

SLD:

T261_3021

SLC:	SL103_30650

SXI:	SXIM_36380

STRM:

M444_22050

STRC:

AA958_22585 AA958_24250

SAMB:

SAM23877_3798(uppS)

SPRI:

SPRI_2843

SCZ:	ABE83_12315 ABE83_33315

SCX:	AS200_18650

SRW:	TUE45_05547

STRF:

ASR50_22945

SLE:	sle_26800(sle_26800)

SRN:	A4G23_03681

SPAV:

Spa2297_16675

STRT:

A8713_20165

SCLF:

BB341_09085 BB341_29945

SGS:	AVL59_05935 AVL59_18480

STSI:

A4E84_25905

SKY:	D0C37_22210

SALW:

CP975_22510

SGM:	GCM10017557_28670(uppS)

SCAD:

DN051_15135

SPHW:

NFX46_05360

SLS:	SLINC_5413

SNR:	SNOUR_16240(uppS1) SNOUR_37660(uppS)

SALU:

DC74_5189

SALL:

SAZ_27585

SPLU:

LK06_021265

STRD:

NI25_19105

SNW:	BBN63_11405

SAUO:

BV401_28200

SSIA:

A7J05_13615

SVU:	B1H20_23485 B1H20_26065

SPUN:

BFF78_15960

SGV:	B1H19_26135

SLAU:

SLA_4877

SALF:

SMD44_05616

SALJ:

SMD11_2499 SMD11_6329

SLX:	SLAV_14405

STRO:

STRMOE7_24815

SFK:	KY5_2231c KY5_5153

SNZ:	DC008_22370

SGE:	DWG14_03086

SRJ:

SRO_2758

SLK:	SLUN_25590

SDX:	C4B68_14365

SGD:	ELQ87_14185

SQZ:	FQU76_01635 FQU76_22405

SCYA:

EJ357_29640

SAST:

CD934_11605

SNQ:	CP978_21585

STIR:

DDW44_19550

SKA:	CP970_15465 CP970_31335(uppS)

SGZ:	C0216_04210

SVN:	CP980_12425

SNK:	CP967_11725 CP967_27925

SHAW:

CEB94_26355

SRK:	FGW37_20995

SFIC:

EIZ62_11515

SGAL:

CP966_23505

SSPO:

DDQ41_22235

SVR:	CP971_13175

SPAD:

DVK44_22900

SFY:	GFH48_15790

SAQU:

EJC51_31115

SGF:	HEP81_02971

SCAV:

CVT27_22265

SSEO:

D0Z67_18665 D0Z67_28165

SBY:	H7H31_11445

SRIM:

CP984_14215

SSUB:

CP968_12550

SPHV:

F9278_32395

SCIN:

CP977_22110

SFUG:

CNQ36_22815

SPAC:

B1H29_18480

STSU:

B7R87_22165

SCHA:

CP983_15500

SGX:	H4W23_26000

SCOE:

CP976_27840

SBAT:

G4Z16_10755

SSPB:

CP982_26870

SNF:	JYK04_05394

SPLA:

CP981_25010

SBRO:

GQF42_27600

STUI:

GCM10017668_45800(uppS)

SATA:

C5746_26705 C5746_35320

SCHF:

IPT68_23185

SHUN:

DWB77_02922

SHAR:

HUT13_18050

SCYG:

S1361_25000

SFEU:

IM697_38665

SLIA:

HA039_11725

SDW:	K7C20_23840

SVD:	CP969_24690

SCAL:

I6J39_23230 I6J39_25760

SAUH:

SU9_022460

SFB:	CP974_18225 CP974_19920

SMOB:

J7W19_20645

SPRA:

CP972_22860

SPEU:

CGZ69_22690

SROI:

IAG44_14180

SXN:	IAG42_12625

SGJ:	IAG43_20455

SHK:	J2N69_23660

SANU:

K7396_13055

SDD:	D9753_12890

SACT:

DMT42_24985

SMAO:

CAG99_08260

SGOB:

test1122_17955

SINE:

KI385_28935

SLF:	JEQ17_17375

SDEC:

L3078_29790

SAOV:

G3H79_12635

SDUR:

M4V62_16640

SYAN:

NRK68_21650

SRUG:

F0345_09265

SAKB:

K1J60_15565

STAA:

LDH80_15035

SNIG:

HEK616_60120(uppS)

SVIO:

HWN34_20795

SCAE:

IHE65_15840

STUB:

MMF93_21275

SSPN:

LXH13_25615

SCIR:

STRCI_000701 STRCI_005224

SXT:	KPP03845_104791 KPP03845_300035(uppS)

SLON:

LGI35_27995

SDRZ:

NEH16_11260

STUD:

STRTU_002460

STEE:

F3L20_04810

SENG:

OJ254_04195

SGK:	PET44_20795

SANT:

QR300_16835

SYUN:

MOV08_16155

SARG:

HKX69_12425

SJN:	RI060_14505

SCYN:

N8I84_25470

SOV:	QZH56_11410

SFIY:

F0344_11930

SHAU:

K9S39_17190

SKG:	KJK29_12305

SCOA:

QU709_14450

SLAI:

P8A22_13750

SROC:

RGF97_11080

SFP:	QUY26_03385(uppS) QUY26_13430

SCHG:

NRO40_19250

STTN:

BSL84_21395

SINN:

ABB07_13905

STRZ:

OYE22_11135

SCT:	SCAT_3893(uppS)

SCY:	SCATT_38790

KSK:	KSE_47670(uppS2) KSE_73590(uppS3)

KAB:	B7C62_21465 B7C62_23840

KAU:	B6264_08230

KIT:	CFP65_0189 CFP65_4723

KIS:	HUT16_03810(uppS) HUT16_21825

STRI:

C7M71_019250

YIA:	LO772_20855

STRH:

GXP74_04925

ABRY:

NYE86_13300(uppS) NYE86_29995

AGLA:

OIE69_16390

TWH:

TWT_331

TWS:	TW440(uppS1)

LXL:	KDY119_02701

PSIC:

J4E96_16190

LXX:	Lxx16850(uppS)

LXY:	O159_19340

LEIF:

HF024_12575

LSE:	F1C12_00280

CMI:	CMM_2236(uppS2)

CMH:	VO01_10385

CMS:	CMS2423(uppS)

CMC:	CMN_02210(uppS2)

CCAP:

AES38_10890

CZH:	H9X71_11280

CPHA:

FGI33_01970

CCAF:

FGD68_13590

MTS:	MTES_3009(uppS)

MIM:	AKG07_00760

MIO:	AOA12_08050

MIX:	AB663_001837

MIP:	AXH82_11830

MCW:	A8L33_12425

MPAL:

BO218_02005

MIH:	BJP65_15150

MICR:

BMW26_05325

MAUR:

BOH66_07115

MHOS:

CXR34_07110

MFOL:

DXT68_05395

MOO:	BWL13_01770

MLV:	CVS47_01943

MWA:	E4K62_11995

MPRT:

ET475_13695

MSED:

E3O41_05235

MOY:	CVS54_02528

MSF:	IT882_10750

MCAW:

F6J84_05225

MLZ:	F6J85_11405

MCHN:

HCR76_05705

MRN:	K8F61_00975

MICS:

C1N74_09195

MBIN:

LXM64_05945

MLIQ:

NMQ05_12120

MTEC:

OAU46_05840

MPAO:

IZR02_05160

MAZA:

NFX31_05360

MNF:	JSY13_03235

MSUW:

GCM10025863_15510(uppS)

MARK:

QUC20_09170

MRG:	SM116_12230

MINV:

T9R20_07260

MEST:

PTQ19_04450

MOJ:	D7D94_01245

RLA:	Rhola_00009950

RPLA:

A4Z71_01925

AQG:	HRU87_01945

AQK:	AKACHI_09460(uppS_2)

RTX:	TI83_08305

RTC:	APU90_08775

RTN:	A6122_1831

RRY:	C1O28_08690

RIA:	C7V51_07365

RFS:	C1I64_02840

RTE:	GSU10_10030

CUM:	NI26_03870

CUB:	BJK06_03745

CUG:	C1N91_03730

CQF:	GBG65_11125

CCIT:

QPK07_04030

MVD:	AWU67_09535

FRP:	AX769_08770

FSB:	GCM10025867_18950(uppS)

AGY:	ATC03_07035

AGM:	DCE93_03845

AGF:	ET445_09195

AARC:

G127AT_12900

AMAU:

DSM26151_20320

ASOI:

MTP13_11085

AMAV:

GCM10025877_04440(uppS_1)

ALAV:

MTO99_08105

AIL:	FLP10_14305

CART:

PA27867_2335

CRY:	B7495_11610

CPHY:

B5808_11305

AMIN:

AUMI_19640

AUM:	AURMO_01315

AUW:	AURUGA1_00394

PSAI:

C3B54_11529

MALK:

MalAC0309_0857(uppS)

CHRE:

IE160_02845

MHUM:

NNL39_02055

MDB:	OVN18_08305

MYL:	C3E77_10160

MSPO:

KXZ72_13785

SALC:

C2138_09710

SALA:

ESZ53_13295

SALD:

FVA74_10380

HUM:	DVJ78_09665

HUW:	FPZ11_06250

GRY:	D7I44_03025

LYD:	D7I47_09370

LYK:	FLP23_05865

PLAP:

EAO79_10870

LEU:	Leucomu_02000

LTR:	EVS81_11890(uppS)

LEB:	G7066_04000

LDN:	H9L06_10140

LVI:	G7068_13110

LINS:

G7067_05135

LLUT:

K1X41_06185

LARI:

KI794_02635

LALL:

MUN78_02515

LRP:	MUN76_06530

LTN:	KVY00_11420

AGG:	C1N71_10560(uppS)

AGRO:

JSQ78_05515(uppS)

MANT:

BHD05_06645

HEA:	HL652_10290

HEH:	L3i23_23440(uppS_2)

FRN:	F1C15_05250

GLN:	F1C58_12215

AGX:	AGREI_2079(uppS)

SUBT:

KPL76_13805

SUBA:

LQ955_03470

PSEV:

USB125703_01324

GSD:	M3M28_04715

GMN:	GMOLON4_1436(uppS)

HOM:	OF852_00335

NAEI:

GCM126_05780(uppS)

LYH:	FrondiHNR_10365

AOG:	LH407_03415

ART:

Arth_1173

ARR:	ARUE_c12270(uppS1)

ARM:

ART_3941

ARL:	AFL94_03575

ARE:	AL755_05730

AAQ:	AOC05_02500

ARW:	MB46_02130

ARH:	AHiyo8_17670

ARY:	ATC04_14300

ARZ:	AUT26_05690

ARU:	ASPU41_11175

ARQ:	BWQ92_03930

ARN:	CGK93_06805

ARX:	ARZXY2_2723

ACRY:

AC20117_13905

ARTH:

C3B78_05755

ARTP:

E5206_17435

AAGI:

NCTC2676_1_00759

AJG:	KKR91_04720

ASUN:

KG104_04800

ASUF:

MNQ99_13880

ARTY:

AHiyo4_13710

APOA:

J0916_02180

AWW:	G8758_01280

ACAO:

NF551_04665

AZH:	MUK71_04845

AGEG:

MUG94_04610

AOD:	Q8Z05_13725

AKO:	N9A08_04770

AZX:	N2K95_04395

AJR:	N2K98_04460

ARI:	UM93_00475

AAU:	AAur_1291(uppS)

PUE:	FV140_06480

PNV:	JMY29_06140

ACH:

Achl_1244

APN:	Asphe3_12040

PSUL:

AU252_04260

PSNI:

NIBR502771_19610

PSEY:

GU243_22505

PDEL:

JCQ34_05800

POK:	SMD14_06225

AAI:	AARI_07540(uppS1)

GAR:	AOZ07_04195

GCR:	GcLGCM259_0600

GLU:	F0M17_03885

GPR:	JQN66_03970

GMI:	NMP99_04400

GMY:

XH9_04885

GNC:	QQS42_04065

RSA:	RSal33209_3046

KRH:

KRH_17650

KPL:	KPaMU14_09490

KFV:	AS188_07095

KII:	KocCE7_09420

KRS:	EQG70_13045

KOD:	HBK84_09370

KVR:	CIB50_0001335

MLU:	Mlut_05130

MICK:

B1A86_00002320

MYU:	M8233_02340

MLY:	CJ228_000380

MPOR:

KW076_11840

MTEU:

R3I42_00290

RMU:	RMDY18_16210

RDN:	HMPREF0733_11386

RAJ:	RA11412_1056

RTER:

IDM49_09050

RAMA:

IDM48_08925

RKR:	I6G21_06530

SATK:

SA2016_1424

NAE:	BHE16_05190

AUL:	DCC27_006410(uppS)

AIG:	QDX25_06195(uppS)

CIG:	E7744_11235

CMUA:

P8192_04505

PAEY:

KUF55_03820

PALU:

CJ193_002940

BCV:	Bcav_1084 Bcav_3752

BFA:	Bfae_23040

BRX:	BH708_07995

BRV:	CFK39_03895

BGG:	CFK41_04985

BRZ:	CFK38_07255

BSAU:

DWV08_09005(uppS)

BRR:	C1N80_07420

BKI:	M4486_00450

BRHA:

NLU66_08075

BHH:	Bra3105_16295

BHQ:	BRM3_00345

DVA:	DAD186_06030

DJJ:	COP05_07860(uppS)

DHM:	CYJ49_003040(uppS)

HMM:	R3I40_07170(uppS)

JDE:

Jden_1887

KSE:	Ksed_07300

DNI:	HX89_11055

DAY:	FV141_10270

DERM:

H7F30_07010

LMOI:

VV02_09215 VV02_24595

YIM:	J5M86_03415

ALX:	LVQ62_17285

BEI:	GCM100_28350(uppS_2)

XCE:

Xcel_2629

XYL:	ET495_09435

XYA:	ET471_01955

IVA:	Isova_2459

IDO:

I598_3280

CET:	B8281_08525

CPRT:

FIC82_007375

SKE:	Sked_08270

SANW:

G7063_11410

CFL:

Cfla_0946

CFI:

Celf_2942

CGA:	Celgi_0671

CEZ:	CBP52_00120

CELZ:

E5225_13245

CEJ:	GC089_13930

CELH:

GXP71_01110

CIRA:

LFM56_13605

CPAL:

F1D97_06990

CELC:

K5O09_04160

CDON:

KKR89_04655

CWAN:

KG103_04995

CFEN:

KG102_03315

CWN:	NP075_04895

CCHE:

NP064_04235

CXIE:

NP048_04885

OEK:	FFI11_018425

PSEI:

GCE65_03790

PSEK:

GCM125_20870(uppS)

ICA:	Intca_0997

ARS:	ADJ73_00365

JTE:	ASJ30_12110

JLI:	EXU32_02275

JME:	EEW87_003185

JAY:	H7A72_12440

JCR:	O9K63_08385

TEH:	GKE56_16260

PHW:	G7075_11870

PEI:	H9L10_01640

TED:	U5C87_10260

SERJ:

SGUI_1302

SERW:

FY030_02675

ORN:	DV701_15515

ORZ:	FNH13_16360

OCP:	NF557_14185

BLY:	A2T55_07310

BLIN:

BLSMQ_1549

BRI:	FDF13_08400(uppS)

BLUT:

EW640_05650

BCAU:

I6G59_10360

BSPO:

L1F31_07395

DCO:	SAMEA4475696_2148

AUS:	IPK37_12805

GEZ:	FE251_02420

GYU:	FE374_04310

HALT:

IM660_14690

RHAL:

LQF10_04930

RSUA:

LQF12_12540

DEM:	LGT36_008685

DSS:	GCM25873_16520(uppS_2)

PAC:

PPA0564

PAK:	HMPREF0675_3624

PAV:	TIA2EST22_02835

PAX:	TIA2EST36_02810

PAZ:	TIA2EST2_02755

PAW:	PAZ_c05990(uppS1)

PAD:	TIIST44_11650

PCN:	TIB1ST10_02920

PACC:

PAC1_02935

PACH:

PAGK_1566

PACN:

TIA1EST1_02875

CACN:

RN83_03375

PRA:	PALO_07950

PRL:	BCB70_11565

CGRN:

4412665_00875

CEQU:

O6R08_02515(uppS)

PFR:	PFREUD_17010(uppS)

PFRE:

RM25_1615

PACD:

EGX94_03610(uppS)

PAUS:

NCTC13651_00592

PPC:	HMPREF9154_2688(uppS_2)

ARUB:

J5A65_12630

PBO:	PACID_10430

AACI:

ASQ49_15995

ACIJ:

JS278_02271

AJI:	C0Z10_09515

MPH:

MLP_43780

MIK:	FOE78_15730(uppS) FOE78_20030

MICG:

GJV80_03230(uppS) GJV80_12455

TFL:	RPIT_10535

TFA:	BW733_12225

TES:	BW730_10930

TEZ:	BKM78_04610

TDF:	H9L22_09895

TLA:	TLA_TLA_00937

TEJ:	KDB89_03240

RAIN:

Rai3103_10930

PRV:	G7070_03815

BRT:	J4N02_12790

PROP:

QQ658_10060

BROO:

brsh051_07160

NCA:

Noca_1056

NDK:

I601_2034

NOY:	EXE57_16080

NOI:	FCL41_03360

NOO:	FE634_05935

NDP:	E2C04_04125

NSN:	EXE58_03045

NBE:	Back2_23180(uppS)

NANO:

G5V58_17405

NMES:

H9L09_13930

NARO:

CFH99_07155

NPI:	G7071_00920

NAQU:

ENKNEFLB_03744

NRO:	K8W59_03795

NOQ:	LN652_08415

NCQ:	K6T13_13830

NPC:	KUV85_00490

NPS:	KRR39_00630

NMAR:

HPC71_04720

NFC:	KG111_13675

PSIM:

KR76_07505

AER:	AERYTH_12845

AEZ:	C3E78_13270

AEB:	C6I20_11740

AEF:	GEV26_13320

ASEZ:

H9L21_03540

ADB:	NP095_03445

AWN:	NQV15_04040

MGG:	MPLG2_3945(uppS)

MUZ:	H4N58_04525

SGRG:

L0C25_04080 L0C25_21465(uppS)

NBT:	KLP28_11830

KFL:	Kfla_5604 Kfla_6572

KQI:	F1D05_12240 F1D05_17600(uppS)

KSL:	OG809_02830 OG809_30090(uppS)

TFU:

Tfu_0456

THAO:

NI17_022990

TALX:

FOF52_20070

NDA:

Ndas_0101

NAL:	B005_2900(uppS)

NGV:	CDO52_06700

NEX:	NE857_06460

NEC:	KGD82_22970

NAKE:

KGD83_25300

NCG:	KGD84_27205

STRR:

EKD16_03455

SNAH:

OUQ99_26810

SAIU:

J4H86_21980

TCU:

Tcur_1075

ACTW:

F7P10_30545

AGRA:

AGRA3207_005760

AMAZ:

LUW76_16490

ACIR:

OG979_10700

SPIQ:

OHA34_29880

ACTQ:

OG417_43485

SRO:

Sros_8524

NOA:	BKM31_10045 BKM31_51260

NOW:	GBF35_31265(uppS) GBF35_44850

NCX:	Nocox_25215 Nocox_37150

NGN:	LCN96_31400(uppS) LCN96_50110

NFS:	OIE67_17455(uppS) OIE67_54345

TBI:

Tbis_3093

MHAI:

OHB01_04925

FRA:	Francci3_2214

FRE:	Franean1_3075

FAL:	FRAAL3564(uppS)

ACE:

Acel_1881

NML:

Namu_4413

NAK:	EH165_03665

NAKA:

H7F38_23090

GOB:

Gobs_0950

BSD:	BLASA_0816(uppS)

MMAR:

MODMU_1002(ispU)

KRA:

Krad_1106

SEN:	SACE_0919(uppS1)

SACG:

FDZ84_16475

SVI:	Svir_31580

SACC:

EYD13_17520

AMD:	AMED_8075(uppS)

AMN:

RAM_41485

AMM:	AMES_7953(uppS)

AMZ:	B737_7954(uppS)

AOI:	AORI_6902 AORI_7736

AJA:	AJAP_04605(uppS1)

AMQ:	AMETH_5870(uppS)

AMYC:

CU254_32925

AMYB:

BKN51_27720

AAB:	A4R43_23620

AMYY:

YIM_05135(uppS1)

AORI:

SD37_06185

AACD:

LWP59_33600

APRT:

MUY14_43885

AROO:

NQK81_31520

ATHM:

L1857_32330

ARHD:

VSH64_29740

PDX:

Psed_0949

PSEE:

FRP1_22395

PSEH:

XF36_20635

PSEQ:

AD006_01585

PECQ:

AD017_09410

PHH:	AFB00_06685

PAUT:

Pdca_10570(uppS_1)

PBRO:

HOP40_03515

PPEL:

H6H00_03990

APRE:

CNX65_03565 CNX65_22715

AMI:

Amir_0714

SESP:

BN6_07920(uppS1)

SSYI:

EKG83_03770

KAL:	KALB_3795 KALB_876

KUT:	JJ691_32580 JJ691_53850(uppS_1) JJ691_69100(uppS_3)

KBU:	Q4V64_33555

KPHY:

AOZ06_06330

LED:	BBK82_09925

ACTA:

C1701_07815 C1701_21865

ALO:

CRK61594

PMAD:

BAY61_26620

SACE:

GIY23_03855

ACTU:

Actkin_00734

CROS:

N8J89_37120

ACTY:

OG774_26775

UME:	RM788_20410(uppS) RM788_29540

STP:	Strop_0863

SAQ:

Sare_0809

MAU:	Micau_0857

MIL:

ML5_1100

MICB:

MicB006_0895

MTUA:

CSH63_20210

MICH:

FJK98_04565

MTEM:

GCE86_29760

MCAB:

HXZ27_05145

MSAG:

GCM10017556_33990(uppS)

VMA:	VAB18032_08975

MCRA:

ID554_08540

VER:	HUT12_04470

MENO:

Jiend_19990(uppS)

MCHL:

PVK74_25545

MFEU:

H1D33_10890 H1D33_25305(uppS)

MPRN:

Q3V37_02735

MHAW:

RMN56_07395

ASE:

ACPL_7710

AMS:	AMIS_74350

ACTN:

L083_7467

AFS:

AFR_39270

ACTS:

ACWT_7580

AIH:	Aiant_35630(uppS_1) Aiant_88210(uppS_2)

ACTR:

Asp14428_55240(uppS)

ACTL:

L3i22_059080 L3i22_100420(uppS)

ASIC:

Q0Z83_095560

AOU:	ACTOB_004678(uppS) ACTOB_008044

PLK:	CIK06_15115(uppS) CIK06_24810

PLAB:

C6361_30765(uppS) C6361_35280

PLAT:

C6W10_09925 C6W10_35335(uppS)

PFLA:

Pflav_063400(uppS)

PSUU:

Psuf_025250(uppS)

ATL:	Athai_05670(uppS_1) Athai_43130

ASER:

Asera_01340(uppS_1) Asera_31500(uppS_2)

PRY:	Prubr_00720(uppS_1) Prubr_34260(uppS_2) Prubr_44890

CATI:

CS0771_19010(uppS)

DVC:	Dvina_04940

DFU:	Dfulv_05335

DROS:

Drose_04755

DAUR:

Daura_04655

DMAT:

Dmats_04540

NHY:	JQS43_02625 JQS43_23810(uppS)

CCAZ:

COUCH_04700

CAI:

Caci_0733

SNA:

Snas_0732

NAV:	JQS30_02845

GLY:	K3N28_12115

AHE:

Arch_1503

ARCA:

HC352_07665

APHO:

JTE88_07680

APII:

NG665_07385

AWL:	P8A24_01725

ACAS:

P7079_01480

MCU:	HMPREF0573_10797

TPY:	CQ11_05640

TPYO:

X956_02045

TBW:	NCTC13354_00689

TPEC:

HLG82_01240

TBER:

QPC17_01075

ASG:	FB03_04485

AUU:	CJ184_004355

ATIM:

CYJ17_0009350

ACTT:

DDD63_02740

AMY:	ADJ76_01105

SOO:	FBF35_08085

STUC:

G5S47_05965

ACQ:	AM609_11040

AOS:	AXE84_06690

ARD:	AXF14_02705

ACTP:

B6G06_01310

ACTC:

CHIBA101_2112

ACTO:

C3V41_10595(uppS)

ANE:	ATCC27039_27300(uppS)

AHW:	NCTC11636_02212

ACTZ:

CWT12_02695

AIR:	NCTC12972_00061

ASLA:

NCTC11923_00090

AVC:	NCTC10951_02696

AWE:	JG540_08710

AMAM:

HPC72_08695

AREP:

ID810_01500

AGH:	M3I41_02170

ACTM:

HCQ94_00945

AMAS:

QU670_12170

ACAP:

MANAM107_07160(uppS_1)

AUO:	R3I39_03960

ALIL:

D5R93_10790

AVU:	BK816_06300

FSL:	EJO69_10655

FLH:	EJ997_12350

WIK:	H8R18_02440

WNE:	PIG85_07990

GEU:	CJ185_002050

GHM:	CJ187_005170

VCB:	CYK25_004105

PHON:

BH719_03645

AEY:	CDG81_18430

PLAN:

A1s21148_00930

PLIM:

PHILAsVB114_01055

PVN:	A7sIIA15_06020

EKE:	EK0264_14150

JTL:	M6D93_15885

JCY:	M6B22_15890

DRA:

DR_2447

DGE:

Dgeo_0020

DDR:	Deide_01980(uppS)

DMR:	Deima_0476

DPT:	Deipr_1889

DGO:	DGo_CA2915(uppS)

DPD:	Deipe_1131

DSW:	QR90_14335

DCH:	SY84_10880

DAB:	AUC44_01800

DPU:	SU48_01760

DEZ:	DKM44_01290

DWU:	DVJ83_10080

DFC:

DFI_00705

DEIN:

DAAJ005_15665

DGA:	DEGR_03740(uppS)

DPH:	EHF33_09140

DRD:	LMT64_10300

DRB:	N0D28_02920

DAH:	DAETH_31440(uppS)

DAQU:

M8445_03595

DTAE:

LAJ19_00675

DMB:	E5F05_06280

TRA:

Trad_2870

TTH:

TT_C1551

TTJ:	TTHA1915(TTHA1915)

TTS:	Ththe16_1915

TTL:	TtJL18_1997

TSC:	TSC_c01840(uppS)

THC:	TCCBUS3UF1_21090

TOS:	Theos_1941

TAQ:

TO73_0090

TPAR:

AV541_01220

TBC:	A0O31_00878

TANT:

KNN15_05090

MRB:

Mrub_0809

MRE:	K649_03685

MTAI:

Mtai_v1c22190

MSV:	Mesil_0446

MICA:

P0L94_02550

MOX:	DAMO_2077(ispU)

» show all

Reference

1 [PMID:11152452]

Authors

Schulbach MC, Mahapatra S, Macchia M, Barontini S, Papi C, Minutolo F, Bertini S, Brennan PJ, Crick DC.

Title

Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis.

Journal

J Biol Chem 276:11624-30 (2001)
DOI:10.1074/jbc.M007168200

Sequence

[mtu:Rv1086]

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.68

IUBMB Enzyme Nomenclature:

2.5.1.68

ExPASy - ENZYME nomenclature database:

2.5.1.68

BRENDA, the Enzyme Database:

2.5.1.68

DBGET integrated database retrieval system