KEGG ENZYME: 2.5.1.76

ENZYME: 2.5.1.76

Entry

EC 2.5.1.76                 Enzyme

Name

cysteate synthase;
sulfite:O-phospho-L-serine sulfotransferase (phosphate-hydrolysing, L-cysteate-forming)

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

sulfite:O-phospho-L-serine sulfonotransferase (phosphate-hydrolysing, L-cysteate-forming)

Reaction(IUBMB)

O-phospho-L-serine + sulfite = L-cysteate + phosphate [RN:R09530]

Reaction(KEGG)

R09530

Substrate

O-phospho-L-serine [CPD:C01005];
sulfite [CPD:C00094]

Product

L-cysteate [CPD:C00506];
phosphate [CPD:C00009]

Comment

A pyridoxal-phosphate protein. It is highly specific for O-phospho-L-serine and sulfite. The reaction proceeds through a dehydroalanine (2-aminoacrylic acid) intermediate. The enzyme from Methanosarcina acetivorans is evolutionarily related to threonine synthase (EC 4.2.3.1), but the reaction is more similar to that of O-phosphoserine sulfhydrylase (EC 2.5.1.65).

History

EC 2.5.1.76 created 2009

Orthology

K15527

cysteate synthase

Genes

SBH:	SBI_01127(thrC1)

SLS:	SLINC_0745

SSPB:

CP982_37255

SROI:

IAG44_03570

SAOV:

G3H79_02195

SCOA:

QU709_42295

KAU:	B6264_25020

SESP:

BN6_58880(sam27)

KBU:	Q4V64_47565

ATL:	Athai_14040

TSIN:

OXH18_20690

MPRO:

BJP34_24920

OSP:	Odosp_0306

BUY:	D8S85_04840

BVIR:

I6J59_10235

BFH:	F1611_04645

AFD:

Alfi_3017

ALD:	GFH31_10570

AOK:	A3BBH6_26810

ACOU:

A5CBH24_22940

ADA:	A5CPEGH6_21060

AIT:	AI2BBH_17830

APUT:

L6V35_09585

ASEN:

NQ519_14510

AIU:	NQ491_03445

RBC:	BN938_1527

BACC:

BRDCF_p1063

DORI:

FH5T_07005

DRC:	G0Q07_00405

MCOS:

GM418_10265

ASX:	CDL62_02870

ALKQ:

M9189_09390

MBAS:

ALGA_4376

FPL:

Ferp_0996

GAC:

GACE_0966

GAH:

GAH_01909

MBA:	Mbar_A3541

MBY:	MSBRM_2301

MBW:	MSBRW_1194

MBAR:

MSBR2_0111

MBAK:

MSBR3_0082

MAC:	MA_3297(thrC)

MMA:

MM_0133

MMAZ:

MmTuc01_0142

MMJ:	MSMAS_1199

MMAC:

MSMAC_2537

MVC:	MSVAZ_2304

MEK:	MSKOL_2312

MLS:	MSLAZ_2127

METM:

MSMTP_1160

MEF:	MSWH1_1038

MEQ:	MSWHS_1109

MSJ:	MSSAC_1624

MSZ:	MSSIH_1219

MSW:	MSSIT_1277

MTHR:

MSTHT_0114

MTHE:

MSTHC_0614

MHOR:

MSHOH_1390

MFZ:	AOB57_001890

MBU:

Mbur_1454

MMET:

MCMEM_1953

MELO:

J7W08_08675

MMH:

Mmah_1753

MHAZ:

BHR79_04915

MPOT:

BKM01_01040

MZH:	Mzhil_0778

MPY:

Mpsy_2145

MZI:	HWN40_11505

MMAV:

RE476_11740

MSEB:

RE474_08635

MHZ:	Metho_1762

MEHF:

MmiHf6_07360(thrC_2)

MEES:

MmiEs2_02280(thrC_1)

MTP:

Mthe_0680

MCJ:

MCON_0195

MHI:

Mhar_1114

MHU:

Mhun_2977

MRTJ:

KHC33_02000

MLA:

Mlab_0503

MEM:	Memar_0111

MBG:	BN140_0055(thrC1)

MEMA:

MMAB1_0058

MCHK:

MchiMG62_02920

MSUM:

OH143_07345

MPI:

Mpet_0280

MEND:

L6E24_14280

MEFW:

F1737_09690

MAQE:

RJ40_07435

MFK:	E2N92_07660

MOU:	OU421_06885

MESB:

L1S32_10285

MANQ:

L1994_09485

MBN:

Mboo_2116

MPL:

Mpal_2734

MPD:

MCP_1992

MEZ:

Mtc_1468

RCI:	LRC440(thrC-2)

MEAM:

MU439_06700

MEAE:

QEN48_03455

MAX:	MMALV_07780

MER:	MMINT_17990

MEUZ:

KRP56_03520

» show all

Reference

1 [PMID:19761441]

Authors

Graham DE, Taylor SM, Wolf RZ, Namboori SC

Title

Convergent evolution of coenzyme M biosynthesis in the Methanosarcinales: cysteate synthase evolved from an ancestral threonine synthase.

Journal

Biochem J 424:467-78 (2009)
DOI:10.1042/BJ20090999

Sequence

[mac:MA_3297]

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.76

IUBMB Enzyme Nomenclature:

2.5.1.76

ExPASy - ENZYME nomenclature database:

2.5.1.76

BRENDA, the Enzyme Database:

2.5.1.76

DBGET integrated database retrieval system