KEGG   ENZYME: 2.5.1.80
Entry
EC 2.5.1.80                 Enzyme                                 
Name
7-dimethylallyltryptophan synthase;
7-DMATS;
dimethylallyl-diphosphate:L-tryptophan 7-dimethylallyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
prenyl-diphosphate:L-tryptophan 7-prenyltransferase
Reaction(IUBMB)
prenyl diphosphate + L-tryptophan = diphosphate + 7-prenyl-L-tryptophan [RN:R09638]
Reaction(KEGG)
R09638
Substrate
prenyl diphosphate [CPD:C00235];
L-tryptophan [CPD:C00078]
Product
diphosphate [CPD:C00013];
7-prenyl-L-tryptophan [CPD:C19767]
Comment
This enzyme is more flexible towards the aromatic substrate than EC 2.5.1.34 (4-dimethylallyltryptophan synthase), but similar to that enzyme, accepts only prenyl diphosphate as the prenyl donor.
History
EC 2.5.1.80 created 2010
Orthology
K14131  tryptophan 7-dimethylallyltransferase
Genes
PPSA: QC764_501815
CHIG: CH63R_12104
AFM: AFUA_3G12930
NFI: NFIA_064390
ABE: ARB_07861
TVE: TRV_04719
MORE: E1B28_009488
Reference
1  [PMID:18481055]
  Authors
Kremer A, Li SM
  Title
Potential of a 7-dimethylallyltryptophan synthase as a tool for production of prenylated indole derivatives.
  Journal
Appl Microbiol Biotechnol 79:951-61 (2008)
DOI:10.1007/s00253-008-1505-3
  Sequence
[afm:AFUA_3G12930]
Reference
2  [PMID:17906140]
  Authors
Kremer A, Westrich L, Li SM
  Title
A 7-dimethylallyltryptophan synthase from Aspergillus fumigatus: overproduction, purification and biochemical characterization.
  Journal
Microbiology 153:3409-16 (2007)
DOI:10.1099/mic.0.2007/009019-0
  Sequence
[afm:AFUA_3G12930]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.80
IUBMB Enzyme Nomenclature: 2.5.1.80
ExPASy - ENZYME nomenclature database: 2.5.1.80
BRENDA, the Enzyme Database: 2.5.1.80

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (7)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (3)   
   InterPro (3)   
All databases (19)   

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