Entry
Name
hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific];
HexPS (ambiguous);
hexaprenyl pyrophosphate synthetase (ambiguous);
hexaprenyl diphosphate synthase (ambiguous);
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate farnesyltranstransferase (adding 3 units of 3-methylbut-3-en-1-yl)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + 3 (3-methylbut-3-en-1-yl diphosphate) = 3 diphosphate + all-trans-hexaprenyl diphosphate [RN:
R09245 ]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:
C00448 ];
3-methylbut-3-en-1-yl diphosphate [CPD:
C00129 ]
Product
diphosphate [CPD:
C00013 ];
all-trans-hexaprenyl diphosphate [CPD:
C01230 ]
Comment
The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and prenyl diphosphate [1].
History
EC 2.5.1.83 created 1984 as EC 2.5.1.33, part transferred 2010 to EC 2.5.1.83
Pathway
ec00900 Terpenoid backbone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K05355 hexaprenyl-diphosphate synthase
K21274 hexaprenyl-diphosphate synthase small subunit
K21275 hexaprenyl-diphosphate synthase large subunit
Genes
NCS : NCAS_0I01970(NCAS0I01970)
NDI : NDAI_0A06570(NDAI0A06570)
TPF : TPHA_0A04460(TPHA0A04460)
TBL : TBLA_0F00560(TBLA0F00560)
TDL : TDEL_0D04200(TDEL0D04200)
KAF : KAFR_0F02550(KAFR0F02550)
KNG : KNAG_0J01180(KNAG0J01180)
CAL : CAALFM_CR00570WA(CaO19.7478)
NTE : NEUTE1DRAFT124027(NEUTE1DRAFT_124027)
PLJ : VFPFJ_02060 VFPFJ_08069
BFU : BCIN_02g05540(Bccoq1)
ZTR : MYCGRDRAFT_73426(COQ1)
CCAC : CcaHIS019_0305350(COQ1)
DSQ : DICSQDRAFT_173926 DICSQDRAFT_176811
LBC : LACBIDRAFT_251291 LACBIDRAFT_335947
CCI : CC1G_00492 CC1G_05865
ABP : AGABI1DRAFT117445(AGABI1DRAFT_117445) AGABI1DRAFT121951(AGABI1DRAFT_121951)
ABV : AGABI2DRAFT123328(AGABI2DRAFT_123328) AGABI2DRAFT214023(AGABI2DRAFT_214023)
MRR : Moror_7207 Moror_8053
MORE : E1B28_001638 E1B28_004206
SCM : SCHCO_02488796(SCHCODRAFT_02488796) SCHCO_02492233(SCHCODRAFT_02492233) SCHCO_02641733(SCHCODRAFT_02641733) SCHCO_02697952(SCHCODRAFT_02697952)
PTRC : PtA15_13A363 PtA15_1A555 PtA15_1A569
PSTR : Pst134EA_000298 Pst134EA_000303
MACR : BHM04_03485 BHM04_03495
MARY : LAU42_05990 LAU42_06000
MBRU : MGG13_06470 MGG13_06480
MEPI : KFV12_07710 KFV12_07720
MBOC : QSV55_06085 QSV55_06095
MCL : MCCL_1121(hepB2) MCCL_1123(hepB1)
MCAK : MCCS_13080(hexs-b) MCCS_13100(hexs-a)
MBOE : HT586_07190 HT586_07200
» show all
Taxonomy
Reference
Authors
Fujii H, Koyama T, Ogura K.
Title
Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components.
Journal
J Biol Chem 257:14610-2 (1982)
Sequence
Reference
Authors
Shimizu N, Koyama T, Ogura K
Title
Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase.
Journal
Sequence
Reference
Authors
Nagaki M, Kimura K, Kimura H, Maki Y, Goto E, Nishino T, Koyama T
Title
Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.83
ExPASy - ENZYME nomenclature database: 2.5.1.83