Entry
Name
all-trans-nonaprenyl diphosphate synthase [geranyl-diphosphate specific];
nonaprenyl diphosphate synthase (ambiguous);
solanesyl diphosphate synthase (ambiguous);
SolPP synthase (ambiguous);
SPP-synthase (ambiguous);
SPP synthase (ambiguous);
solanesyl-diphosphate synthase (ambiguous);
OsSPS2
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 7 isopentenyl units)
Reaction(IUBMB)
geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate [RN:
R09250 ]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:
C00341 ];
isopentenyl diphosphate [CPD:
C00129 ]
Product
diphosphate [CPD:
C00013 ];
all-trans-nonaprenyl diphosphate [CPD:
C04145 ]
Comment
(2E,6E)-Farnesyl diphosphate and geranylgeranyl diphosphate are less effective as substrates than geranyl diphosphate. The enzyme is involved in the synthesis of the side chain of menaquinone-9 [1]. In Oryza sativa the enzyme SPS2 is involved in providing solanesyl diphosphate for plastoquinone-9 formation [3].
History
EC 2.5.1.84 created 1972 as EC 2.5.1.11, part transferred 2010 to EC 2.5.1.84
Pathway
ec00900 Terpenoid backbone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K05356 all-trans-nonaprenyl-diphosphate synthase
Genes
ATH : AT1G17050(SPS2) AT1G78510(SPS1)
ALY : 110225373 9304798 9323808
CSAT : 104702634 104713531 104740392 104751747 104756029 104775809
EUS : EUTSA_v10007715mg EUTSA_v10018616mg
BNA : 106346730 106354554 106354696 106365558
THJ : 104810419 104812299 104813987 104822586
MINC : 123201391 123229888
GHI : 107891827 107895305 107915414 107920469
HSYR : 120123256 120162503 120164653
LJA : Lj0g3v0072399.1(Lj0g3v0072399.1) Lj0g3v0072399.2(Lj0g3v0072399.2)
LANG : 109334617 109357382
QSA : O6P43_001116 O6P43_029257
MSYL : 126590530 126616763
CMAX : 111480364 111482773
CMOS : 111437508 111447291
CPEP : 111789795 111810913
SIND : 105165488 105176904
OEU : 111368875 111374720 111389251
SSPL : 121783697 121787504 121803081 121807016
SMIL : 131012133 131012140
APAN : 127254261 127265938
CSIN : 114274488 114289614
PSOM : 113287425 113295653
DOSA : Os05t0582300-01(Os05g0582300)
TAES : 123069734 123183265
LRD : 124648205 124706977 124707012
ZMA : 100191875 100282721 103653367
SITA : 101761340 101780515
PVIR : 120665997 120699238
PHAI : 112883879 112884053
ZOF : 121981590 121985468 122002606 122006850
NCOL : 116249055 116264365
SMO : SELMODRAFT_177791 SELMODRAFT_446259
MPP : MICPUCDRAFT_23095(JGI:MicpuC2_23095)
SMIN : v1.2.008416.t1(symbB.v1.2.008416.t1)
SYR : SynRCC307_1159(preA)
SYX : SynWH7803_1038(preA)
SYNW : SynWH8103_01143(sds)
TVN : NIES2134_116780(sds)
LET : O77CONTIG1_01361(hepT)
SYP : SYNPCC7002_A0580(sdsA)
SYNN : NIES970_03170(sdsA)
PRUN : PCC7821_00437(preA)
NSPH : BDGGKGIB_00348(hepT)
» show all
Taxonomy
Reference
Authors
Sagami H, Ogura K, Seto S
Title
Solanesyl pyrophosphate synthetase from Micrococcus lysodeikticus.
Journal
Reference
Authors
Fujii H, Sagami H, Koyama T, Ogura K, Seto S, Baba T, Allen CM.
Title
Variable product specificity of solanesyl pyrophosphate synthetase.
Journal
Reference
Authors
Ohara K, Sasaki K, Yazaki K
Title
Two solanesyl diphosphate synthases with different subcellular localizations and their respective physiological roles in Oryza sativa.
Journal
Sequence
Reference
Authors
Ohnuma S, Koyama T, Ogura K
Title
Purification of solanesyl-diphosphate synthase from Micrococcus luteus. A new class of prenyltransferase.
Journal
J Biol Chem 266:23706-13 (1991)
Reference
Authors
Gotoh T, Koyama T, Ogura K
Title
Farnesyl diphosphate synthase and solanesyl diphosphate synthase reactions of diphosphate-modified allylic analogs: the significance of the diphosphate linkage involved in the allylic substrates for prenyltransferase.
Journal
Reference
Authors
Teclebrhan H, Olsson J, Swiezewska E, Dallner G
Title
Biosynthesis of the side chain of ubiquinone:trans-prenyltransferase in rat liver microsomes.
Journal
J Biol Chem 268:23081-6 (1993)
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.84
ExPASy - ENZYME nomenclature database: 2.5.1.84