Entry
Name
all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific];
nonaprenyl diphosphate synthase (ambiguous);
solanesyl diphosphate synthase (ambiguous);
At-SPS2;
At-SPS1;
SPS1;
SPS2
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 5 isopentenyl units)
Reaction(IUBMB)
geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate [RN:
R09251 ]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:
C00353 ];
isopentenyl diphosphate [CPD:
C00129 ]
Product
diphosphate [CPD:
C00013 ];
all-trans-nonaprenyl diphosphate [CPD:
C04145 ]
Comment
Geranylgeranyl diphosphate is preferred over farnesyl diphosphate as allylic substrate [1]. The plant Arabidopsis thaliana has two different enzymes that catalyse this reaction. SPS1 contributes to the biosynthesis of the ubiquinone side-chain while SPS2 supplies the precursor of the plastoquinone side-chains [2].
History
EC 2.5.1.85 created 1972 as EC 2.5.1.11, part transferred 2010 to EC 2.5.1.85
Pathway
ec00900 Terpenoid backbone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K05356 all-trans-nonaprenyl-diphosphate synthase
Genes
ATH : AT1G17050(SPS2) AT1G78510(SPS1)
ALY : 110225373 9304798 9323808
CSAT : 104702634 104713531 104740392 104751747 104756029 104775809
EUS : EUTSA_v10007715mg EUTSA_v10018616mg
BNA : 106346730 106354554 106354696 106365558
THJ : 104810419 104812299 104813987 104822586
MINC : 123201391 123229888
GHI : 107891827 107895305 107915414 107920469
HSYR : 120123256 120162503 120164653
LJA : Lj0g3v0072399.1(Lj0g3v0072399.1) Lj0g3v0072399.2(Lj0g3v0072399.2)
LANG : 109334617 109357382
QSA : O6P43_001116 O6P43_029257
MSYL : 126590530 126616763
CMAX : 111480364 111482773
CMOS : 111437508 111447291
CPEP : 111789795 111810913
SIND : 105165488 105176904
OEU : 111368875 111374720 111389251
SSPL : 121783697 121787504 121803081 121807016
SMIL : 131012133 131012140
SHIS : 125196618 125215398
APAN : 127254261 127265938
CSIN : 114274488 114289614
PSOM : 113287425 113295653
DOSA : Os05t0582300-01(Os05g0582300)
TAES : 123069734 123183265
LRD : 124648205 124706977 124707012
ZMA : 100191875 100282721 103653367
SITA : 101761340 101780515
PVIR : 120665997 120699238
PHAI : 112883879 112884053
ZOF : 121981590 121985468 122002606 122006850
NCOL : 116249055 116264365
SMO : SELMODRAFT_177791 SELMODRAFT_446259
MPP : MICPUCDRAFT_23095(JGI:MicpuC2_23095)
SMIN : v1.2.008416.t1(symbB.v1.2.008416.t1)
SYR : SynRCC307_1159(preA)
SYX : SynWH7803_1038(preA)
SYNW : SynWH8103_01143(sds)
TVN : NIES2134_116780(sds)
LET : O77CONTIG1_01361(hepT)
SYP : SYNPCC7002_A0580(sdsA)
SYNN : NIES970_03170(sdsA)
PRUN : PCC7821_00437(preA)
NSPH : BDGGKGIB_00348(hepT)
» show all
Taxonomy
Reference
Authors
Hirooka K, Bamba T, Fukusaki E, Kobayashi A
Title
Cloning and kinetic characterization of Arabidopsis thaliana solanesyl diphosphate synthase.
Journal
Sequence
Reference
Authors
Hirooka K, Izumi Y, An CI, Nakazawa Y, Fukusaki E, Kobayashi A
Title
Functional analysis of two solanesyl diphosphate synthases from Arabidopsis thaliana.
Journal
Sequence
Reference
Authors
Jun L, Saiki R, Tatsumi K, Nakagawa T, Kawamukai M
Title
Identification and subcellular localization of two solanesyl diphosphate synthases from Arabidopsis thaliana.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.85
ExPASy - ENZYME nomenclature database: 2.5.1.85