KEGG ENZYME: 2.5.1.89

ENZYME: 2.5.1.89

Entry

EC 2.5.1.89                 Enzyme

Name

tritrans,polycis-undecaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

geranylgeranyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 7 isopentenyl units)

Reaction(IUBMB)

geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate [RN:R09730]

Reaction(KEGG)

R09730

Substrate

geranylgeranyl diphosphate [CPD:C00353];
isopentenyl diphosphate [CPD:C00129]

Product

diphosphate [CPD:C00013];
tritrans,heptacis-undecaprenyl diphosphate [CPD:C19852]

Comment

This enzyme is involved in the biosynthesis of the glycosyl carrier lipid in some archaebacteria. Unlike EC 2.5.1.31, its counterpart in most bacteria, it prefers geranylgeranyl diphosphate to farnesyl diphosphate as the allylic substrate, resulting in production of a tritrans,polycis variant of undecaprenyl diphosphate [1].

History

EC 2.5.1.89 created 2010, modified 2011

Pathway

ec00900

Terpenoid backbone biosynthesis

Orthology

K15888

tritrans,polycis-undecaprenyl-diphosphate synthase [geranylgeranyl-diphosphate specific]

Genes

MJA:

MJ_1372

MFE:	Mefer_0013

MVU:	Metvu_0730

MFS:	MFS40622_0557

MIF:	Metin_0747

MJH:	JH146_0409

MESG:

MLAUSG7_0959(uppS)

MESA:

MLASG1_0294(uppS)

MIG:	Metig_0007

MMP:

MMP1345

MMQ:	MmarC5_0233

MMX:	MmarC6_1328

MMZ:	MmarC7_0590

MMD:

GYY_07550

MMAK:

MMKA1_15680(uppS)

MMAO:

MMOS7_14490(uppS)

MMAD:

MMJJ_14940

MAE:

Maeo_1136

MVN:	Mevan_0656

MVO:

Mvol_0149

MOK:	Metok_0698

METF:

CFE53_05195(uppS)

MTH:

MTH_232

MMG:	MTBMA_c06810(uppS)

MWO:	MWSIV6_0644(uppS)

MTEE:

MTTB_08750

METC:

MTCT_0194

METE:

tca_00212

METZ:

METMT2_0676

METK:

FVF72_01145(uppS)

MTHM:

FZP57_03065(uppS)

METJ:

FZP68_08100(uppS)

MST:	Msp_1182(uppS)

METB:

AW729_09855

MEIS:

PXD04_01710(uppS)

MRU:	mru_1005(uppS)

MSI:

Msm_0096

MEB:	Abm4_0676(uppS)

MMIL:

sm9_0974(uppS)

MEYE:

TL18_05495

MOL:

YLM1_0546

MARO:

MarbSA_04520

METV:

K4897_00900(uppS)

MEL:	Metbo_2128

MEW:	MSWAN_0483

METH:

MBMB1_0608(uppS)

MFC:	BRM9_1627(uppS)

MFI:	DSM1535_2322(uppS)

MCUB:

MCBB_0494(uppS)

MSUB:

BK009_01135

METN:

BK008_08825

METT:

CIT01_09500(uppS)

METO:

CIT02_03890(uppS)

MEME:

HYG87_09880(uppS)

MFEG:

GCM10025860_16180 GCM10025860_19110

MFV:

Mfer_0595

MKA:	MK0767(uppS)

AFU:

AF_1219

AFG:	AFULGI_00013180

APO:	Arcpr_0491

AVE:	Arcve_0125

AST:	Asulf_00506

FPL:

Ferp_1985

GAC:

GACE_0233

GAH:

GAH_00064

PFU:

PF1599

PFI:

PFC_07225

PHO:	PH1590(PH1590)

PAB:	PAB0394(hypoth)

PYN:

PNA2_0175

PYA:	PYCH_04910

PYS:

Py04_1477

PYC:	TQ32_08915

TKO:

TK1173

TON:

TON_0373

TGA:	TGAM_0719(uppS)

TSI:

TSIB_1513

TBA:	TERMP_00685

THE:

GQS_03365

THA:

TAM4_934

THM:

CL1_0304

TLT:

OCC_03007

THS:

TES1_0768

TNU:

BD01_0338

TEU:

TEU_07395

TGY:	X802_06815

THV:	ADU37_CDS16370

TCH:	CHITON_1826

TPEP:

A0127_09070

TPIE:

A7C91_07885

TGG:	A3K92_05410

TCE:	A3L02_09525

TBS:	A3L01_02570

THH:	CDI07_02520(uppS)

TSL:	A3L11_06495

TTD:	A3L14_04035

TPRF:

A3L09_07815

TRL:	A3L10_04015

TPAF:

A3L08_05560

THY:	A3L12_06160

TIC:	FH039_04835(uppS)

TCQ:	TIRI35C_0737(uppS)

THEM:

FPV09_04325(uppS)

THEI:

K1720_00380(uppS)

PPAC:

PAP_02925

MBA:	Mbar_A0263

MBY:	MSBRM_2692

MBW:	MSBRW_0733

MBAR:

MSBR2_2648

MBAK:

MSBR3_2777

MAC:	MA_3723(uppS)

MMA:

MM_0618

MMAZ:

MmTuc01_0629

MMJ:	MSMAS_0691

MMAC:

MSMAC_0692

MVC:	MSVAZ_0672

MEK:	MSKOL_0650

MLS:	MSLAZ_2243

METM:

MSMTP_0756

MEF:	MSWH1_0870

MEQ:	MSWHS_0929

MSJ:	MSSAC_3535

MSZ:	MSSIH_3076

MSW:	MSSIT_3134

MTHR:

MSTHT_2395

MTHE:

MSTHC_0884

MHOR:

MSHOH_0806

MFZ:	AOB57_003440(uppS)

MBU:

Mbur_0041

MMET:

MCMEM_0626

MELO:

J7W08_01190(uppS)

MMH:

Mmah_1238

MHAZ:

BHR79_07355

MPOT:

BKM01_03600

MEV:	Metev_0825 Metev_2270

MZH:	Mzhil_1185

MPY:

Mpsy_1109

MZI:	HWN40_03045(uppS)

MMAV:

RE476_07200(uppS)

MSEB:

RE474_03465(uppS)

MHZ:	Metho_1987

MEHF:

MmiHf6_01370(uppS_1)

MEES:

MmiEs2_08520(uppS_1)

MTP:

Mthe_0589

MCJ:	MCON_0296(uppS)

MHI:

Mhar_2350

MHU:

Mhun_0785

MRTJ:

KHC33_09690(uppS)

MLA:

Mlab_0118

MEM:	Memar_1788

MBG:	BN140_0601(uppS)

MEMA:

MMAB1_0780(uppS)

MCHK:

MchiMG62_20500

MSUM:

OH143_03155(uppS)

MRC:	R6Y96_08595(uppS)

MPI:

Mpet_0736

MEND:

L6E24_04925(uppS)

MEFW:

F1737_07380(uppS)

MAQE:

RJ40_09710(uppS)

MFK:	E2N92_09930(uppS)

MOU:	OU421_12925(uppS)

MESB:

L1S32_04680(uppS)

MANQ:

L1994_07620(uppS)

MBN:

Mboo_2063

MFO:	Metfor_0792

MPL:

Mpal_0107

MPD:	MCP_1817(uppS)

MEZ:	Mtc_1306(uppS-2)

RCI:	RRC441(uppS-2)

HAL:

VNG_1779C

HSL:	OE_3503F(uppS1)

HANR:

LJ422_07170(uppS)

HDL:	HALDL1_13885

HHB:	Hhub_3075(uppS1)

HAGS:

JT689_08515(uppS)

HABO:

JRZ79_06925(uppS)

HNO:	LT974_12305(uppS)

HLU:	LT972_02610(uppS)

HALH:

HTSR_0407

HHSR:

HSR6_0392(uppS2)

HSU:	HLASF_1850(uppS1)

HSF:	HLASA_1836(uppS1)

HAHS:

HSRCO_2460(uppS)

SALR:

FQU85_06950(uppS)

HALR:

EFA46_001210(uppS)

HJE:	HacjB3_06135

HDO:	MUK72_12540(uppS)

HALX:

M0R89_02070(uppS)

HAXZ:

M0R88_02045(uppS)

HAYC:

NGM10_12020(uppS)

HAXY:

NGM07_07480(uppS)

SALI:

L593_09975

SAIM:

K0C01_03025(uppS)

HARA:

AArcS_0442(uppS)

HMA:	rrnAC1716(uppS)

HHI:	HAH_2250(uppS1)

HHN:	HISP_11460

HAB:	SG26_03830

HTA:	BVU17_10985

HALJ:

G9465_16135(uppS)

HSIN:

KDQ40_02130(uppS)

NPH:	NP_4550A(uppS1)

NMO:	Nmlp_2341(uppS1)

NHO:	HWV23_03155(uppS)

NSAL:

HWV07_17065(uppS)

HUT:

Huta_2829

HTI:

HTIA_2734

HALA:

Hrd1104_05035(uppS)

HASV:

SVXHr_1747(uppS2)

HABN:

HBNXHr_1734(uppS2)

HMU:

Hmuk_1548

HALZ:

E5139_10865(uppS)

HALL:

LC1Hm_0765(uppS)

HAZP:

GBQ70_10860(uppS)

HALI:

BV210_13510

HSN:	DV733_13415(uppS)

HDS:	HSR122_1525(uppS)

HRR:	HZS55_13135(uppS)

HPEL:

HZS54_17080(uppS)

HLT:	I7X12_00640(uppS)

HARC:

HARCEL1_06025(uppS)

SSAI:

N0B31_12275(uppS)

HAAD:

MW046_02285(uppS)

HWA:	HQ_3332A(uppS2)

HWC:	Hqrw_3861(uppS2)

HVO:	HVO_2315(uppS1)

HME:	HFX_2325(uppS)

HGI:	ABY42_11520

HALE:

G3A49_14790(uppS)

HLS:	KU306_01670(uppS)

HLN:	SVXHx_2297(uppS2)

HBO:	Hbor_07310

HAQ:	DU484_16985(uppS)

HAJ:	DU500_00030(uppS)

HAER:

DU502_15195(uppS)

HRA:	EI982_15070(uppS)

HLM:	DV707_01865(uppS)

HALM:

FCF25_03620(uppS)

HLA:

Hlac_2063

HALP:

DOS48_09765(uppS)

HALB:

EKH57_14675(uppS)

HEZZ:

EO776_10170(uppS)

HALQ:

Hrr1229_012105(uppS)

HSS:	J7656_05270(uppS)

HSAI:

HPS36_03735(uppS) HPS36_10485(uppS)

HAZZ:

KI388_09475(uppS)

SRUB:

C2R22_16735(uppS)

HAE:	halTADL_0759 halTADL_1546

HALN:

B4589_014625(uppS)

HALG:

HUG10_08895(uppS)

HALU:

HUG12_07165(uppS)

HMP:	K6T50_06435(uppS)

HRE:	K6T36_06210(uppS)

HRM:	K6T25_09575(uppS)

HACB:

Hbl1158_13150(uppS)

HDF:	AArcSl_1515

HAH:	Halar_2577

HTU:

Htur_3250

HSAL:

JMJ58_12205(uppS)

HAKZ:

J0X25_04460(uppS)

NMG:	Nmag_1224(uppS1)

HXA:	Halxa_2121

NAT:

NJ7G_2495

NPE:	Natpe_0579

NVR:	FEJ81_03230(uppS)

NPL:	FGF80_07730(uppS)

NAY:	HYG81_07640(uppS)

HALY:

HYG82_10385(uppS)

HJT:	DVR14_12120(uppS)

HLO:	J0X27_13255(uppS)

NGE:	Natgr_3192

HRU:	Halru_2195

SAWL:

NGM29_01480(uppS)

HALV:

NGM15_11090(uppS)

NOU:	Natoc_2038

HLR:	HALLA_17025

HLC:	CHINAEXTREME08125

NAJ:	B1756_11845

NAG:	AArcMg_3021

NAN:	AArc1_0682

NARA:

QQ977_04530(uppS)

NBG:	DV706_03890(uppS)

NAS:	GCU68_09075(uppS)

HDA:	BB347_00350

MEAM:

MU439_01005(uppS)

MEAE:

QEN48_01600(uppS)

TAC:

Ta0546

TVO:	TVG0591988(TVG0591988)

PTO:

PTO1378

FAC:	FACI_IFERC01G1594

FAI:

FAD_0573

CDIV:

CPM_0361

TAR:	TALC_00206

MAX:	MMALV_01930

MER:	MMINT_01960

MEAR:

Mpt1_c12690(uppS)

MEUZ:

KRP56_01080(uppS)

MARC:

AR505_1636

ABI:

Aboo_0417

ACF:	AciM339_0631

ACJ:	ACAM_0874(uppS)

SMR:

Smar_1245

SHC:	Shell_1211

IHO:

Igni_0586

IIS:

EYM_01550

IPC:

IPA_03285

DKA:

DKAM_0927

DFD:	Desfe_1048

DMU:	Desmu_0134

TAG:

Tagg_0145

IAG:

Igag_0013

THG:	TCELL_0064

HBU:

Hbut_1087

PFM:	Pyrfu_1960

PDL:	Pyrde_0981

PABI:

PABY_07930(uppS)

PARE:

PYJP_13650(uppS)

STO:	STK_01890(uppS)

SOH:	D1869_00415(uppS)

SSO:

SSO0163

SOL:

Ssol_1140

SSOA:

SULA_1176(uppS)

SSOL:

SULB_1177(uppS)

SSOF:

SULC_1175(uppS)

SSHI:

J5U23_00102

SCAS:

SACC_00750

SAI:

Saci_0757

SACN:

SacN8_03680

SACR:

SacRon12I_03665

SACS:

SUSAZ_03395

SIS:	LS215_2142

SIA:	M1425_1977

SIM:	M1627_2055

SID:

M164_1983

SIY:	YG5714_2100

SIN:	YN1551_0818

SII:

LD85_2238

SIH:

SiH_1921

SIR:

SiRe_1848

SIC:

SiL_1830

SULA:

BFU36_05125

SULE:

GFS03_10830(uppS)

SULL:

EWF20_01855(uppS)

MSE:

Msed_0171

MEMJ:

MJ1HA_0250

MCN:

Mcup_1902

MHK:	DFR87_05955(uppS)

MPRU:

DFR88_05785(uppS)

MTEN:

GWK48_06235(uppS)

MJN:	MjAS7_0754

AHO:

Ahos_0890

AMAN:

B6F84_08300

ABRI:

DFR85_06545(uppS)

ASUL:

DFR86_07315(uppS)

AAMB:

D1866_12345(uppS)

ACIH:

HS5_22650

SACD:

HS1genome_0851

SAZO:

D1868_01560(uppS)

CSTY:

KN1_18100

STEP:

IC006_1909

SMET:

RQ359_002314(uppS)

SAHS:

HS7_19990

PIS:

Pisl_0348

PCL:

Pcal_1157

PAS:

Pars_1319

PYR:

P186_1582

POG:

Pogu_0896

TNE:

Tneu_1777

PYW:	PYWP30_01898

CMA:

Cmaq_0786

TTN:	TTX_0656(uppS)

TUZ:

TUZN_0298

VDI:

Vdis_0938

VMO:

VMUT_1786

VSO:	Vsou_11070

TPE:

Tpen_0762

THB:	N186_05330

TCB:	TCARB_0131

THF:	MA03_05695

THEL:

IG193_03675(uppS)

ASC:

ASAC_1265

ACIA:

SE86_07500

CLG:	Calag_0868

FFO:	FFONT_1224

NMR:

Nmar_1416

NIR:	NSED_07775

NKR:	NKOR_07805

NID:	NPIRD3C_2077(uppS)

NIN:	NADRNF5_0463(uppS)

NIW:	Nisw_06890(uppS)

NCL:	C5F47_07515(uppS)

NOX:	C5F49_07395(uppS)

NUE:	C5F50_10710(uppS)

NIP:	NsoK4_01175(uppS)

NZT:	NZOSNM25_000359

NCT:	NMSP_0329(uppS)

NIC:	DSQ20_08340(uppS)

NGA:	Ngar_c35510(uppS)

NVN:	NVIE_018850

NEV:

NTE_00400

TAA:	NMY3_03347

NFN:	NFRAN_0752(uppS)

NCV:	NCAV_0511(uppS)

CSY:	CENSYa_1470

CSU:	CSUB_C0295

NBV:	T478_0360(uppS)

TAH:	SU86_008615

NIU:	DSQ19_07980(uppS)

NDV:	NDEV_1710(uppS)

CCAI:

NAS2_0133

KCR:

Kcr_0245

BARC:

AOA65_0926(uppS)

BARB:

AOA66_0322(uppS)

NAA:

Nps_02790

MARH:

Mia14_0585

FLT:	Sv326_1286

MIY:	Micr_00783(uppS_2)

LOKI:

Lokiarch_02280(uppS_1) Lokiarch_37300(uppS_2)

LOB:	NEF87_003594

PSYT:

DSAG12_01206(uppS)

AGW:	QT03_C0001G0549 QT03_C0001G0683(uppS) QT03_C0001G0830

ARG:	QT11_C0001G0984

» show all

Reference

1 [PMID:11114943]

Authors

Hemmi H, Yamashita S, Shimoyama T, Nakayama T, Nishino T

Title

Cloning, expression, and characterization of cis-polyprenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus acidocaldarius.

Journal

J Bacteriol 183:401-4 (2001)
DOI:10.1128/JB.183.1.401-404.2001

Sequence

[sai:Saci_0757]

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.89

IUBMB Enzyme Nomenclature:

2.5.1.89

ExPASy - ENZYME nomenclature database:

2.5.1.89

BRENDA, the Enzyme Database:

2.5.1.89

DBGET integrated database retrieval system