KEGG ENZYME: 2.5.1.92

ENZYME: 2.5.1.92

Entry

EC 2.5.1.92                 Enzyme

Name

(2Z,6Z)-farnesyl diphosphate synthase;
cis,cis-farnesyl diphosphate synthase;
Z,Z-FPP synthase;
zFPS;
Z,Z-farnesyl pyrophosphate synthase;
dimethylallyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 2 isopentenyl units)

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

prenyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 2 isopentenyl units)

Reaction(IUBMB)

prenyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + (2Z,6Z)-farnesyl diphosphate [RN:R09633];
(1a) prenyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate [RN:R01659];
(1b) neryl diphosphate + isopentenyl diphosphate = diphosphate + (2Z,6Z)-farnesyl diphosphate [RN:R12638]

Reaction(KEGG)

R01659 R09633 R12638

Substrate

prenyl diphosphate [CPD:C00235];
isopentenyl diphosphate [CPD:C00129];
neryl diphosphate [CPD:C02569]

Product

diphosphate [CPD:C00013];
(2Z,6Z)-farnesyl diphosphate [CPD:C19760];
neryl diphosphate [CPD:C02569]

Comment

This enzyme, originally characterized from wild tomato, specifically forms (2Z,6Z)-farnesyl diphosphate via neryl diphosphate and isopentenyl diphosphate. In wild tomato it is involved in the biosynthesis of several sesquiterpenes. See also EC 2.5.1.68 [(2Z,6E)-farnesyl diphosphate synthase] and EC 2.5.1.10 [(2E,6E)-farnesyl diphosphate synthase].

History

EC 2.5.1.92 created 2010, modified 2011

Pathway

ec00900

Terpenoid backbone biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K15887

(2Z,6Z)-farnesyl diphosphate synthase

Reference

1 [PMID:19155349]