KEGG ENZYME: 2.5.1.94

ENZYME: 2.5.1.94

Entry

EC 2.5.1.94                 Enzyme

Name

adenosyl-chloride synthase;
chlorinase;
5'-chloro-5'-deoxyadenosine synthase

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

S-adenosyl-L-methionine:chloride adenosyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + chloride = 5-deoxy-5-chloroadenosine + L-methionine [RN:R09639]

Reaction(KEGG)

R09639

Substrate

S-adenosyl-L-methionine [CPD:C00019];
chloride [CPD:C00698]

Product

5-deoxy-5-chloroadenosine [CPD:C19768];
L-methionine [CPD:C00073]

Comment

This enzyme, isolated from the marine bacterium Salinispora tropica, catalyses an early step in the pathway leading to biosynthesis of the proteosome inhibitor salinosporamide A. The enzyme is very similar to EC 2.5.1.63, adenosyl-fluoride synthase, but does not accept fluoride.

History

EC 2.5.1.94 created 2011

Orthology

K21153

adenosyl-chloride synthase

Genes