KEGG ENZYME: 2.6.1.101

ENZYME: 2.6.1.101

Entry

EC 2.6.1.101                Enzyme

Name

L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase

Class

Transferases;
Transferring nitrogenous groups;
Transaminases

Sysname

L-glutamine:5-amino-2,3,4-trihydroxycyclohexanone aminotransferase

Reaction(IUBMB)

L-glutamine + 3-amino-2,3-dideoxy-scyllo-inosose = 2-oxoglutaramate + 2-deoxystreptamine [RN:R08891]

Reaction(KEGG)

R08891

Substrate

L-glutamine [CPD:C00064];
3-amino-2,3-dideoxy-scyllo-inosose [CPD:C17581]

Product

2-oxoglutaramate [CPD:C00940];
2-deoxystreptamine [CPD:C02627]

Comment

Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Also catalyses EC 2.6.1.100, L-glutamine:2-deoxy-scyllo-inosose aminotransferase.

History

EC 2.6.1.101 created 2013

Pathway

ec00524

Neomycin, kanamycin and gentamicin biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K13547

L-glutamine:2-deoxy-scyllo-inosose/3-amino-2,3-dideoxy-scyllo-inosose aminotransferase

Genes

PMUY:

KSS95_17140

PCEL:

HUB94_17990

MOT:	LTS72_25990

NTC:	KHQ06_25020

NHU:	H0264_36130

NYA:	LTV02_00430

SRN:	A4G23_05129(neoB)

SFB:	CP974_27370

CWN:	NP075_08690

AGRA:

AGRA3207_003346

NFS:	OIE67_09805

MCHL:

PVK74_08590

MFEU:

H1D33_23865

RUV:	EC9_13230(stsC)

ACAF:

CA12_03720(btrR)

CCOS:

Pan44_41230(btrR_3)

PVAR:

SH412_001922

UAM:	UABAM_05678

» show all

Reference

1 [PMID:15827636]

Authors

Huang F, Haydock SF, Mironenko T, Spiteller D, Li Y, Spencer JB

Title

The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine.

Journal

Org Biomol Chem 3:1410-8 (2005)
DOI:10.1039/b501199j

Reference

2 [PMID:16506694]

Authors

Kudo F, Yamamoto Y, Yokoyama K, Eguchi T, Kakinuma K

Title

Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773.

Journal

J Antibiot (Tokyo) 58:766-74 (2005)
DOI:10.1038/ja.2005.104

Sequence

[ag:BAD95819]