KEGG ENZYME: 2.6.1.103

ENZYME: 2.6.1.103

Entry

EC 2.6.1.103                Enzyme

Name

(S)-3,5-dihydroxyphenylglycine transaminase;
HpgT

Class

Transferases;
Transferring nitrogenous groups;
Transaminases

Sysname

(S)-3,5-dihydroxyphenylglycine:2-oxoglutarate aminotransferase

Reaction(IUBMB)

(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate [RN:R06634]

Reaction(KEGG)

R06634;
(other) R06626

Substrate

(S)-3,5-dihydroxyphenylglycine [CPD:C12026];
2-oxoglutarate [CPD:C00026]

Product

2-(3,5-dihydroxyphenyl)-2-oxoacetate [CPD:C12325];
L-glutamate [CPD:C00025]

Comment

A pyridoxal-5'-phosphate protein. The enzyme from the bacterium Amycolatopsis orientalis catalyses the reaction in the reverse direction as part of the biosynthesis of the (S)-3,5-dihydroxyphenylglycine constituent of the glycopeptide antibiotic chloroeremomycin.

History

EC 2.6.1.103 created 2013

Pathway

ec00261

Monobactam biosynthesis

ec01055

Biosynthesis of vancomycin group antibiotics

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K16423

(S)-3,5-dihydroxyphenylglycine transaminase

Genes

SMAF:

D781_2332

SERM:

CLM71_12105

SRHZ:

FO014_21605

RBAD:

H2866_19100

DDA:	Dd703_3064

PLU:

plu1105

PLUM:

A4R40_05450

XAL:

XALC_1062

XTN:	FD63_09735 FD63_09805

XEU:	XSP_002199

XHD:	LMG31886_20750(hpgT)

XPR:	MUG10_21485

VEU:	IXK98_24045

PFE:	PSF113_4198

PBA:	PSEBR_a4101

PBC:	CD58_21635

PYM:	AK972_5188

PVK:	EPZ47_20770

PBZ:	GN234_26590

PZA:	HU749_021600

TACT:

SG35_030615

PLZ:	S4054249_22560

PFLI:

CTT31_00575

PMAZ:

R5H13_00580

HCH:

HCH_01676

HAHE:

ENC22_22240

HAHH:

O5O45_17900

HHH:	CLM76_06050

BGL:	bglu_1g22660

BGU:

KS03_3097

BGD:	bgla_1g16570

BGO:

BM43_2883

BGP:	BGL_1c14500

BPLA:

bpln_1g14050

PMEG:

FNZ07_11715

AGE:	AA314_04079

MBD:	MEBOL_005603

CFUS:

CYFUS_001036 CYFUS_002910

NTP:	CRH09_30900

NHU:	H0264_30790

SCO:	SCO3227(SCE63.06)

SGRF:

SGFS_079830

SVL:	Strvi_8790

SHY:

SHJG_1205

SHO:	SHJGH_1040

SRC:	M271_00255 M271_09150 M271_27675

SMAL:

SMALA_7754

SSOI:

I1A49_42605

SBH:

SBI_01124

SALS:

SLNWT_0925

SLV:	SLIV_21555

SVT:	SVTN_32170

STRE:

GZL_08684

SLC:	SL103_26555

SXI:	SXIM_47470

STRC:

AA958_31860

SAMB:

SAM23877_5650

SPRI:

SPRI_0187 SPRI_7166

SPAV:

Spa2297_02905 Spa2297_26655 Spa2297_33005

SKY:	D0C37_02205 D0C37_28250

SALW:

CP975_31975 CP975_34470

SPHW:

NFX46_23640

SNR:	SNOUR_39370

SALU:

DC74_566

SALL:

SAZ_03325

SPLU:

LK06_002720 LK06_031575

SSIA:

A7J05_04095

SLAU:

SLA_6886

STRO:

STRMOE7_29135

SFK:

KY5_6710c

SCYA:

EJ357_01675

SKA:	CP970_03000 CP970_07095 CP970_09770

SGZ:	C0216_32515

SRK:	FGW37_00525

SGAL:

CP966_31745

SVR:	CP971_02380 CP971_08180

SFY:	GFH48_02900 GFH48_36335

SAQU:

EJC51_23020

SBY:	H7H31_03470

SRIM:

CP984_06495

SFUG:

CNQ36_25595

STSU:

B7R87_00125 B7R87_00860

SCHA:

CP983_01440 CP983_10840

SGX:	H4W23_38365

SSPB:

CP982_06160

SATA:

C5746_00985 C5746_42250

SVD:	CP969_02975

SAUH:

SU9_002095

SROI:

IAG44_40620

SXN:	IAG42_36490

SANU:

K7396_35170

SGOB:

test1122_04790

SINE:

KI385_01590

SDUR:

M4V62_39100

SRUG:

F0345_18380 F0345_27915

SNIG:

HEK616_29480(avtA_1) HEK616_51620(avtA_2)

SDRZ:

NEH16_31425

SENG:

OJ254_30620

SANT:

QR300_24020

SYUN:

MOV08_40285

SFIY:

F0344_35085

SHAU:

K9S39_10840

SKG:	KJK29_13140

STRZ:

OYE22_03340

KSK:	KSE_65200 KSE_67440

KAU:	B6264_25025 B6264_28335

KIT:	CFP65_1243

KIS:	HUT16_30925 HUT16_31840

STRH:

GXP74_22690 GXP74_26135

ABRY:

NYE86_02915

KFL:	Kfla_4129 Kfla_6051

KQI:	F1D05_14900

KSL:	OG809_05860

NDA:

Ndas_1742

NAL:

B005_2520

ACTW:

F7P10_10130

AGRA:

AGRA3207_002323

AMAZ:

LUW76_44665

NOA:	BKM31_54170

NCX:	Nocox_13270(noc3)

NGN:	LCN96_07970

FRA:	Francci3_2452

AOI:	AORI_1491 AORI_5327

AJA:	AJAP_32060

AMYB:

BKN51_28925 BKN51_41500

AORI:

SD37_16615 SD37_33665

AROO:

NQK81_15430

AMI:

Amir_4591

SSYI:

EKG83_29585 EKG83_30970

KAL:	KALB_1757 KALB_6130

KUT:	JJ691_47800 JJ691_70390

KBU:	Q4V64_04810

ACTI:

UA75_15375

ACAD:

UA74_14805

ACTA:

C1701_23415

STP:	Strop_2477

SAQ:

Sare_2660

MAU:	Micau_3467

MIL:

ML5_4924

MICB:

MicB006_2521

MTUA:

CSH63_07710

MICH:

FJK98_16510

MTEM:

GCE86_08080 GCE86_13305

MCAB:

HXZ27_18280

MSAG:

GCM10017556_53940(avtA) GCM10017556_56510

VMA:	VAB18032_22225

MCHL:

PVK74_07580

MFEU:

H1D33_22915 H1D33_24955

MHAW:

RMN56_24535

ACTL:

L3i22_092810

AOU:	ACTOB_006419 ACTOB_006462

PFLA:

Pflav_007670

PSUU:

Psuf_064710

ATL:	Athai_14020

PRY:	Prubr_36830(avtA_2) Prubr_64980

CATI:

CS0771_77040(avtA_3)

DVC:	Dvina_13755

DFU:	Dfulv_12395

DAUR:

Daura_12880

DMAT:

Dmats_13290

CAI:

Caci_3266

AEY:	CDG81_10665

SCOR:

J3U87_23940

COY:	HF329_09890

» show all

Reference

Authors

Sandercock, A.M., Charles, E.H., Scaife, W., Kirkpatrick, P.N., O'Brien, S.W., Papageorgiou, E.A., Spencer, J.B. and Williams, D.H.

Title

Biosynthesis of the di-meta-hydroxyphenylglycine constituent of the vancomycin-group antibiotic chloroeremomycin.

Journal

Chem Comm 1252-1253 (2001)

Other DBs

ExplorEnz - The Enzyme Database:

2.6.1.103

IUBMB Enzyme Nomenclature:

2.6.1.103

ExPASy - ENZYME nomenclature database:

2.6.1.103

BRENDA, the Enzyme Database:

2.6.1.103

DBGET integrated database retrieval system