KEGG ENZYME: 2.6.1.105

ENZYME: 2.6.1.105

Entry

EC 2.6.1.105                Enzyme

Name

lysine---8-amino-7-oxononanoate transaminase;
DAPA aminotransferase (ambiguous);
bioA (gene name) (ambiguous);
bioK (gene name)

Class

Transferases;
Transferring nitrogenous groups;
Transaminases

Sysname

L-lysine:8-amino-7-oxononanoate aminotransferase

Reaction(IUBMB)

L-lysine + 8-amino-7-oxononanoate = (S)-2-amino-6-oxohexanoate + 7,8-diaminononanoate [RN:R10699]

Reaction(KEGG)

R10699

Substrate

L-lysine [CPD:C00047];
8-amino-7-oxononanoate [CPD:C01092]

Product

(S)-2-amino-6-oxohexanoate [CPD:C04076];
7,8-diaminononanoate [CPD:C01037]

Comment

A pyridoxal 5'-phosphate enzyme [2]. Participates in the pathway for biotin biosynthesis. The enzyme from the bacterium Bacillus subtilis cannot use S-adenosyl-L-methionine as amino donor and catalyses an alternative reaction for the conversion of 8-amino-7-oxononanoate to 7,8-diaminononanoate (cf. EC 2.6.1.62, adenosylmethionine---8-amino-7-oxononanoate transaminase).

History

EC 2.6.1.105 created 2014

Pathway

ec00780

Biotin metabolism

ec01100

Metabolic pathways

Orthology

K19563

lysine---8-amino-7-oxononanoate aminotransferase

Genes

BSU:	BSU30230(bioA)

BSR:	I33_3077(bioA)

BSL:

A7A1_1653

BSH:	BSU6051_30230(bioK)

BSY:	I653_14470

BSUT:

BSUB_03212(bioK)

BSUL:

BSUA_03212(bioK)

BSUS:

Q433_16395

BSO:	BSNT_09443(bioA)

BSN:	BSn5_05955

BSQ:	B657_30230(bioK)

BSX:	C663_2868(bioK)

BSP:	U712_15005

BSS:	BSUW23_14645(bioK)

BST:	GYO_3271(bioA)

BIT:	BIS30_04485

BLI:	BL00953(bioA)

BLD:	BLi00767(bioA)

BLH:	BaLi_c08650(bioA)

BAY:	RBAM_018280(bioA)

BAQ:	BACAU_1786(bioA)

BYA:	BANAU_1953(bioA)

BAMP:

B938_09455

BQY:	MUS_2182(bioA)

BAML:

BAM5036_1765(bioK)

BAMA:

RBAU_1803(bioK)

BAMN:

BASU_1783(bioK)

BAMB:

BAPNAU_1916(bioA)

BAMT:

AJ82_10385

BAMY:

V529_17980(bioA)

BMP:	NG74_01904(bioK)

BAO:	BAMF_1923(bioK)

BAZ:	BAMTA208_07890(bioK)

BQL:	LL3_02013(bioK)

BXH:	BAXH7_01607(bioA)

BAMI:

KSO_010225

BAMC:

U471_18830

BAMF:

U722_09670

BSIA:

CWD84_11855

BAE:	BATR1942_12905

BVM:	B9C48_09330

BSON:

S101395_00962(bioA)

BHT:	DIC78_16485

BMOJ:

HC660_28870(bioK)

BIQ:	AN935_15130

BSTR:

QI003_18315(bioA)

BGY:	BGLY_0781(bioK)

BBAD:

K7T73_02980(bioA)

BCAB:

EFK13_15360(bioA)

BRY:	M0696_15070(bioA)

BJS:

MY9_3023

BACI:

B1NLA3E_02730

BACP:

SB24_00515

BACB:

OY17_12275

BACO:

OXB_3534

BACY:

QF06_13305

BACL:

BS34A_32870(bioA)

BALM:

BsLM_3007

BACS:

AUL54_01445

BACQ:

DOE78_13825

BAQU:

K6959_16180(bioA)

BHAI:

KJK41_05960(bioA)

BEO:

BEH_11235

BHA:

BH0782

BKW:	BkAM31D_02745(bioK)

BGI:	BGM20_09065

BPF:	BpOF4_04195(bioA)

CFIR:

NAF01_14655(bioA)

AFL:	Aflv_1071(bioA)

AGN:	AFK25_09050

HSHI:

MUO14_17885(bioA)

VIR:	X953_06770

VIL:	CFK37_17920

VPN:	A21D_01032(bioK_1)

RUE:	DT065_18015

MSEM:

GMB29_11990(bioA)

RAZ:	U9J35_06205(bioA)

CTHU:

HUR95_16680(bioA)

ALKL:

MM271_06860(bioA)

DOM:	RRU94_17190(bioA)

AAC:

Aaci_2857

SPOS:

DV702_05505

SPAE:

E2C16_12250(bioA)

SURL:

BI350_00125

LKI:

LKI_05230

LEC:	LGMK_07195

» show all

Reference

1 [PMID:15880481]

Authors

Van Arsdell SW, Perkins JB, Yocum RR, Luan L, Howitt CL, Chatterjee NP, Pero JG

Title

Removing a bottleneck in the Bacillus subtilis biotin pathway: bioA utilizes lysine rather than S-adenosylmethionine as the amino donor in the KAPA-to-DAPA reaction.

Journal

Biotechnol Bioeng 91:75-83 (2005)
DOI:10.1002/bit.20488

Sequence

[bsu:BSU30230]

Reference

2 [PMID:20565114]

Authors

Dey S, Lane JM, Lee RE, Rubin EJ, Sacchettini JC

Title

Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .

Journal

Biochemistry 49:6746-60 (2010)
DOI:10.1021/bi902097j

Sequence

[bsu:BSU30230]

Other DBs

ExplorEnz - The Enzyme Database:

2.6.1.105

IUBMB Enzyme Nomenclature:

2.6.1.105

ExPASy - ENZYME nomenclature database:

2.6.1.105

BRENDA, the Enzyme Database:

2.6.1.105

DBGET integrated database retrieval system