KEGG ENZYME: 2.6.1.106

ENZYME: 2.6.1.106

Entry

EC 2.6.1.106                Enzyme

Name

dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase;
desV (gene name);
megDII (gene name);
eryCI (gene name)

Class

Transferases;
Transferring nitrogenous groups;
Transaminases

Sysname

dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose:2-oxoglutarate aminotransferase

Reaction(IUBMB)

dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose + 2-oxoglutarate = dTDP-3-dehydro-4,6-deoxy-alpha-D-glucose + L-glutamate [RN:R06426]

Reaction(KEGG)

R06426

Substrate

dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose [CPD:C11910];
2-oxoglutarate [CPD:C00026]

Product

dTDP-3-dehydro-4,6-deoxy-alpha-D-glucose [CPD:C11909];
L-glutamate [CPD:C00025]

Comment

A pyridoxal-phosphate protein. The enzyme is involved in the biosynthesis of dTDP-alpha-D-desosamine, a sugar found in several bacterial macrolide antibiotics including erythromycin, megalomicin A, mycinamicin II, and oleandomycin. The reaction occurs in the reverse direction.

History

EC 2.6.1.106 created 2014

Pathway

ec00523

Polyketide sugar unit biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K13310

dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase

K16436

dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase

Genes

DTX:	ATSB10_36020

PTRL:

OU419_09855

OME:	OLMES_5572

BOK:

DM82_922

BOC:

BG90_13

BUU:	WS70_10345

PTRP:

DCO17_01695

CSER:

CCO03_02175

HHF:	E2K99_02740

BGZ:	XH91_11590

BSYM:

CIT39_18485

BSEI:

KMZ68_19085

BROS:

QUH67_25980

RPE:

RPE_1521

TFV:	IDJ81_02380

AOZ:	HUE56_00815

MAGN:

WV31_12980

GEM:

GM21_0941

GUR:

Gura_4276

GEO:

Geob_0430

GBM:

Gbem_3307

GBN:	GEOBRER4_09100

GER:	KP004_03990

GSUB:

KP001_11415

GPL:	M1B72_16735

DMA:

DMR_07600

DCB:	C3Y92_16655

DBR:

Deba_0354

NBR:	O3I_007490

NIE:	KV110_35795

DPC:	A6048_11425

SGR:

SGR_631

SGRF:

SGFS_016280

SCYE:

R2B67_24630

SXI:	SXIM_35740

SAMB:

SAM23877_7111

SLE:	sle_09260(sle_09260)

SRN:	A4G23_00481(fdtB_1) A4G23_02284(fdtB_3)

SPAV:

Spa2297_32850

SCLF:

BB341_29650

SGM:	GCM10017557_01770

SCAD:

DN051_13785

SALF:

SMD44_08276

SFK:	KY5_0020c KY5_8143

SLK:	SLUN_13800

STIR:

DDW44_27825

SKA:	CP970_39865

SHAW:

CEB94_04710

SFIC:

EIZ62_03940 EIZ62_09600

SGAL:

CP966_29030

SSPO:

DDQ41_30670

SPAD:

DVK44_01725

SRIM:

CP984_10775

SPHV:

F9278_28225

SCIN:

CP977_28095

STSU:

B7R87_21940

SCHA:

CP983_27955

SGX:	H4W23_25510

SCOE:

CP976_32980

SFEU:

IM697_37655

SLIA:

HA039_05665

SFB:	CP974_02505 CP974_12570

SMOB:

J7W19_00830

SPEU:

CGZ69_24380

SGJ:	IAG43_33085

SMAO:

CAG99_12110

SAOV:

G3H79_01880

SRUG:

F0345_27610

SAKB:

K1J60_45155

STAA:

LDH80_09665

SNIG:

HEK616_47520

STUD:

STRTU_005103

SJN:	RI060_18320

SHAU:

K9S39_40580

SKG:	KJK29_16120

SCOA:

QU709_45620

SFP:	QUY26_02165

SCHG:

NRO40_12725

STTN:

BSL84_24970

KAB:	B7C62_31175

CRY:	B7495_14410

ARUB:

J5A65_00470

NCA:

Noca_4220

TALX:

FOF52_07485 FOF52_14840

NDA:

Ndas_4709

NAL:

B005_1433

NGV:	CDO52_02790

NEC:	KGD82_07535

NAKE:

KGD83_01610

NCG:	KGD84_13445

STRR:

EKD16_15580(fdtB)

SNAH:

OUQ99_30540

SAIU:

J4H86_24150

TCU:

Tcur_2777

ACTQ:

OG417_42725

NOW:	GBF35_40090

NCX:	Nocox_25585(fdtB)

SEN:	SACE_0734(eryCI)

SVI:	Svir_29860

SACC:

EYD13_16495(fdtB)

AOI:

AORI_1500

AJA:	AJAP_32020(dnrJ)

AMYC:

CU254_17445

AMYB:

BKN51_41540

AMYY:

YIM_11615(fdtB1) YIM_22860(fdtB2)

AORI:

SD37_33620

AROO:

NQK81_15390

PSEQ:

AD006_30040

PECQ:

AD017_31210

SESP:

BN6_58910(sam30)

SSYI:

EKG83_32250

KAL:	KALB_6580(acuN1)

KUT:	JJ691_101530 JJ691_70310

KPHY:

AOZ06_22490 AOZ06_23370

LED:	BBK82_43745

AHM:	TL08_05640

ACTI:

UA75_05680 UA75_17820

ACAD:

UA74_05675 UA74_17285

AHG:	AHOG_05440(fdtB1) AHOG_15460(fdtB2)

ACTA:

C1701_01555

ALO:

CRK56086

PMAD:

BAY61_07750

ACTU:

Actkin_00392(fdtB_1)

CROS:

N8J89_11400

SAQ:

Sare_2337

MAU:	Micau_3988

MIL:

ML5_4433

MICB:

MicB006_4930

MCAB:

HXZ27_04125(evdS12)

MCRA:

ID554_11925 ID554_28075

VER:	HUT12_18910

MENO:

Jiend_53130

MCHL:

PVK74_00295

AMS:	AMIS_50590 AMIS_56730

AOU:	ACTOB_006482

PLAB:

C6361_24070

PLAT:

C6W10_35925

PFLA:

Pflav_057110

PSUU:

Psuf_016700(gnnB) Psuf_058220

DAUR:

Daura_37950

NHY:	JQS43_06860

AEY:	CDG81_13130

PVN:	A7sIIA15_06590

PBAJ:

LRS13_04530

PLS:	VT03_24275(fdtB)

CCOS:

Pan44_47430(fdtB)

LKB:	LPTSP3_g21180

LUB:	TBR22_A49060

» show all

Reference

1 [PMID:17456741]

Authors

Burgie ES, Thoden JB, Holden HM

Title

Molecular architecture of DesV from Streptomyces venezuelae: a PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine.

Journal

Protein Sci 16:887-96 (2007)
DOI:10.1110/ps.062711007

Sequence

[ag:AAC68680]

Other DBs

ExplorEnz - The Enzyme Database:

2.6.1.106

IUBMB Enzyme Nomenclature:

2.6.1.106

ExPASy - ENZYME nomenclature database:

2.6.1.106

BRENDA, the Enzyme Database:

2.6.1.106

DBGET integrated database retrieval system