KEGG ENZYME: 2.6.1.108

ENZYME: 2.6.1.108

Entry

EC 2.6.1.108                Enzyme

Name

(5-formylfuran-3-yl)methyl phosphate transaminase;
mfnC (gene name);
[5-(hydroxymethyl)furan-3-yl]methyl phosphate transaminase

Class

Transferases;
Transferring nitrogenous groups;
Transaminases

Sysname

L-alanine:(5-formylfuran-3-yl)methyl phosphate aminotransferase

Reaction(IUBMB)

L-alanine + (5-formylfuran-3-yl)methyl phosphate = pyruvate + [5-(aminomethyl)furan-3-yl]methyl phosphate [RN:R11038]

Reaction(KEGG)

R11038

Substrate

L-alanine [CPD:C00041];
(5-formylfuran-3-yl)methyl phosphate [CPD:C20954]

Product

pyruvate [CPD:C00022];
[5-(aminomethyl)furan-3-yl]methyl phosphate [CPD:C21068]

Comment

A pyridoxal 5'-phosphate protein. The enzyme, characterized from the archaebacterium Methanocaldococcus jannaschii, participates in the biosynthesis of the cofactor methanofuran. Requires pyridoxal 5'-phosphate.

History

EC 2.6.1.108 created 2015

Pathway

ec00680

Methane metabolism

ec01100

Metabolic pathways

Orthology

K19793

(5-formylfuran-3-yl)methyl phosphate transaminase

Genes

PACE:

A6070_12195

PEF:	A7E78_07625

DVE:	DESUT3_31870

DPG:	DESPIGER_0708

DFL:

DFE_0184

DSB:	LN040_00360

DMA:

DMR_45090

DCB:	C3Y92_19395

DGG:

DGI_1983

DMS:	E8L03_06035

DEJ:	AWY79_08275

PPRF:

DPRO_2977(mfnC)

PSEL:

GM415_08330

PSEF:

PSDVSF_11680

PPOR:

JCM14722_08700

PNW:

SYK_12940

PTHE:

LF599_12765

DSX:	GD604_15970

DSD:	GD606_15175

DAT:	HRM2_10800(aspC2)

DOV:	DSCO28_45510

DWD:	DSCW_41700

DALK:

DSCA_41500

DML:	Dmul_38010(aspC3)

DLI:

dnl_50660

DMM:	dnm_029950

DAX:	FDQ92_12000

DBR:

Deba_0092

DMP:

FAK_38820

BBE:	BBR47_31990

BFM:	BP422_11130

PPQ:	PPSQR21_011610

CCHL:

FPL14_20410

RPAY:

P0092_17135

LPIL:

LIP_0260

CALK:

HUE98_09150

SSYI:

EKG83_24635

BTHO:

Btheta7330_04576(patA_2)

BXY:

BXY_47810

BOA:	Bovatus_03826(patA_3)

DRC:	G0Q07_10800

MCOS:

GM418_26720

MJA:

MJ_0684

MFE:	Mefer_0615

MVU:	Metvu_0344

MFS:	MFS40622_1497

MJH:	JH146_1215

MESG:

MLAUSG7_1004(mfnC)

MESA:

MLASG1_0773(mfnC)

MIG:	Metig_0137

MBA:	Mbar_A1546

MBY:	MSBRM_2902

MBW:	MSBRW_3183

MBAR:

MSBR2_2861

MBAK:

MSBR3_1827

MAC:	MA_0636(aspC)

MMA:

MM_1802

MMAZ:

MmTuc01_1875

MMJ:	MSMAS_2883

MMAC:

MSMAC_1551

MVC:	MSVAZ_2704

MEK:	MSKOL_2708

MLS:	MSLAZ_0359

METM:

MSMTP_2810

MEF:	MSWH1_2805

MEQ:	MSWHS_2230

MSJ:	MSSAC_0572

MSZ:	MSSIH_0522

MSW:	MSSIT_0552

MTHR:

MSTHT_2208

MTHE:

MSTHC_1072

MHOR:

MSHOH_3582

MFZ:	AOB57_004795

MMET:

MCMEM_1376

MELO:

J7W08_05520

MMH:

Mmah_1336

MHAZ:

BHR79_06985

MPOT:

BKM01_03250

MPY:

Mpsy_0899

MZI:	HWN40_04100

MMAV:

RE476_06155

MSEB:

RE474_02375

MHZ:	Metho_0766

MCJ:	MCON_2279(aspC)

MHI:

Mhar_2101

MPD:

MCP_1841

» show all

Reference

1 [PMID:24977328]

Authors

Miller D, Wang Y, Xu H, Harich K, White RH

Title

Biosynthesis of the 5-(Aminomethyl)-3-furanmethanol moiety of methanofuran.

Journal

Biochemistry 53:4635-47 (2014)
DOI:10.1021/bi500615p

Sequence

[mja:MJ_0684]

Other DBs

ExplorEnz - The Enzyme Database:

2.6.1.108

IUBMB Enzyme Nomenclature:

2.6.1.108

ExPASy - ENZYME nomenclature database:

2.6.1.108

BRENDA, the Enzyme Database:

2.6.1.108

DBGET integrated database retrieval system