| Entry |
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| Name |
dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase;
SpnR;
TDP-4-keto-2,3,6-trideoxy-D-glucose 4-aminotransferase
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| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
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| Sysname |
dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose:2-oxoglutarate aminotransferase
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| Reaction(IUBMB) |
dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2-oxoglutarate = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate [RN: R08931]
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| Reaction(KEGG) |
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| Substrate |
dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose [CPD: C18033];
2-oxoglutarate [CPD: C00026]
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| Product |
dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose [CPD: C18032];
L-glutamate [CPD: C00025]
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| Comment |
A pyridoxal-phosphate protein. The enzyme, isolated from the bacterium Saccharopolyspora spinosa, participates in the biosynthesis of forosamine.
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| History |
EC 2.6.1.110 created 2016
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| Pathway |
| ec00523 | Polyketide sugar unit biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K13329 | dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase |
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| Genes |
| SAMB: | SAM23877_5617(srm20) |
» show all
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| Reference |
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| Authors |
Hong L, Zhao Z, Melancon CE 3rd, Zhang H, Liu HW |
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| Title |
In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.6.1.110 |
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