KEGG   ENZYME: 2.6.1.115
Entry
EC 2.6.1.115                Enzyme                                 
Name
5-hydroxydodecatetraenal 1-aminotransferase;
cpkG (gene name)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol:pyruvate aminotransferase
Reaction(IUBMB)
(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol + pyruvate = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + L-alanine [RN:R12343]
Reaction(KEGG)
R12343
Substrate
(2E,5S,6E,8E,10E)-1-aminododeca-2,6,8,10-tetraen-5-ol [CPD:C22091];
pyruvate [CPD:C00022]
Product
(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal [CPD:C22087];
L-alanine [CPD:C00041]
Comment
The enzyme, characterized from the bacterium Streptomyces coelicolor A3(2), participates in the biosynthesis of coelimycin P1, where it catalyses the amination of (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal. L-glutamate can also serve as the amino group donor with lower efficiency.
History
EC 2.6.1.115 created 2019
Orthology
K23397  5-hydroxydodecatetraenal 1-aminotransferase
Genes
SCO: SCO6279(SC1G7.05)
SLV: SLIV_06750
Reference
1  [PMID:17009021]
  Authors
Pawlik K, Kotowska M, Chater KF, Kuczek K, Takano E
  Title
A cryptic type I polyketide synthase (cpk) gene cluster in Streptomyces coelicolor A3(2).
  Journal
Arch Microbiol 187:87-99 (2007)
DOI:10.1007/s00203-006-0176-7
  Sequence
[sco:SCO6279]
Reference
2  [PMID:28451186]
  Authors
Awodi UR, Ronan JL, Masschelein J, de Los Santos ELC, Challis GL
  Title
Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis.
  Journal
Chem Sci 8:411-415 (2017)
DOI:10.1039/c6sc02803a
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.115
IUBMB Enzyme Nomenclature: 2.6.1.115
ExPASy - ENZYME nomenclature database: 2.6.1.115
BRENDA, the Enzyme Database: 2.6.1.115

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (2)   
All databases (9)   

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