KEGG ENZYME: 2.6.1.120

ENZYME: 2.6.1.120

Entry

EC 2.6.1.120                Enzyme

Name

beta-alanine---2-oxoglutarate transaminase;
pydD (gene name);
beta-alanine aminotransferase

Class

Transferases;
Transferring nitrogenous groups;
Transaminases

Sysname

beta-alanine:2-oxoglutarate aminotransferase

Reaction(IUBMB)

beta-alanine + 2-oxoglutarate = 3-oxopropanoate + L-glutamate [RN:R00908]

Reaction(KEGG)

R00908

Substrate

beta-alanine [CPD:C00099];
2-oxoglutarate [CPD:C00026]

Product

3-oxopropanoate [CPD:C00222];
L-glutamate [CPD:C00025]

Comment

The enzyme, found in many Gram-positive bacteria, participates in the reductive degradation of pyrimidines. In eukaryotes this activity is catalysed by EC 2.6.1.19, 4-aminobutyrate---2-oxoglutarate transaminase.

History

EC 2.6.1.120 created 2021

Pathway

ec00410

beta-Alanine metabolism

ec00640

Propanoate metabolism

ec01100

Metabolic pathways

Orthology

K25571

beta-alanine---2-oxoglutarate transaminase

Genes

BNU:	N3Z17_04180

DMS:	E8L03_05125

PSEL:

GM415_00260

BSM:	BSM4216_2471

APAK:

AP3564_07960

BAG:

Bcoa_0948

STEA:

C0679_03165

BTHS:

CNY62_08870

VIE:	OL234_05535

CBE:

Cbei_1936

CBZ:

Cbs_1936

CBEI:

LF65_02103

CKL:

CKL_2404

CKR:

CKR_2120

CLJ:	CLJU_c35920

CLS:	CXIVA_03360

CSR:	Cspa_c41400

CPAS:

Clopa_1050

CPAT:

CLPA_c11050

CPAE:

CPAST_c11050

CAH:	CAETHG_1499

CSQ:

CSCA_2144

CBUT:

ATN24_00665 ATN24_17790

CTYK:

CTK_C12530

CDY:	F3K33_09605

CLOS:

DMR38_18015

CNN:

CNEO_3061

CGEL:

psyc5s11_35380

CINT:

HZF06_13750

CRS:	FQB35_11655

ESR:

ES1_26120

ESU:

EUS_26180

EHA:	Ethha_1174

RCH:

RUM_00520

RUM:

CK1_14970

SGY:

Sgly_1374

BMAS:

LK422_01765

LXA:	OW255_09820

ACEL:

acsn021_20440

ACHT:

bsdcttw_03550

CLE:	Clole_0538

CEW:	EKH84_05935

TSH:

Tsac_2220

HALS:

D7D81_09685

IFN:	GM661_07015

KME:	H0A61_01626(tpa)

CCHA:

ELD05_01765

MEG:	DKB62_06635

RKR:	I6G21_01575

BKA:	AH68_00255

BEU:	BE0216_06990

BSUE:

BS3272_06435

TPI:	TREPR_0423

» show all

Reference

1 [PMID:3085724]

Authors

Fujimoto S, Mizutani N, Mizota C, Tamaki N.

Title

The level of beta-alanine aminotransferase activity in regenerating and differentiating rat liver.

Journal

Biochim Biophys Acta 882:106-12 (1986)
DOI:10.1016/0304-4165(86)90061-9

Reference

2 [PMID:31455636]

Authors

Yin J, Wei Y, Liu D, Hu Y, Lu Q, Ang EL, Zhao H, Zhang Y.

Title

An extended bacterial reductive pyrimidine degradation pathway that enables nitrogen release from beta-alanine.

Journal

J Biol Chem 294:15662-15671 (2019)
DOI:10.1074/jbc.RA119.010406

Sequence

[bsm:BSM4216_2471]

Other DBs

ExplorEnz - The Enzyme Database:

2.6.1.120

IUBMB Enzyme Nomenclature:

2.6.1.120

ExPASy - ENZYME nomenclature database:

2.6.1.120

BRENDA, the Enzyme Database:

2.6.1.120

All links

Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (639)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (54)   
   KEGG MGENES (584)   
All databases (652)   

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