KEGG ENZYME: 2.6.1.122

ENZYME: 2.6.1.122

Entry

EC 2.6.1.122                Enzyme

Name

UDP-N-acetyl-3-dehydro-alpha-D-glucosamine 3-aminotranferase;
gnnB (gene name)

Class

Transferases;
Transferring nitrogenous groups;
Transaminases

Sysname

UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose:2-oxoglutarate aminotransferase

Reaction(IUBMB)

UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate = UDP-N-acetyl-3-dehydro-alpha-D-glucosamine + L-glutamate [RN:R12936]

Reaction(KEGG)

R12936

Substrate

UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose [CPD:C22427];
2-oxoglutarate [CPD:C00026]

Product

UDP-N-acetyl-3-dehydro-alpha-D-glucosamine;
L-glutamate [CPD:C00025]

Comment

This bacterial enzyme participates, together with EC 1.1.1.374, UDP-N-acetylglucosamine 3-dehydrogenase, in the synthesis of 2,3-diamino-2,3-dideoxy-D-glucopyranose, a component of lipid A in some species.

History

EC 2.6.1.122 created 2021

Orthology

K20084

UDP-N-acetyl-3-dehydro-alpha-D-glucosamine 3-aminotranferase

Genes

SAGA:

M5M_05210

MCA:

MCA0399

METU:

GNH96_01430

MMEO:

OOT43_10080

MMT:	Metme_3006

MDN:	JT25_002160

MDH:	AYM39_05475

MKO:	MKLM6_1108

METL:

U737_16770

MPAD:

KEF85_15735

MELL:

IVG45_09150

MRP:	NM686_013925

MMOT:

QZJ86_05295

MAH:	MEALZ_2850(degT)

MBUR:

EQU24_07905

MPSY:

CEK71_02005

MMAI:

sS8_2640

MSZE:

MSZNOR_3642(degT)

MMOB:

F6R98_16230

MEIN:

methR_P2641

MOZ:	MoryE10_20750(gnnB)

MISZ:

MishRS11D_18840(gnnB)

MESL:

KKZ03_21305

NOC:

Noc_1754

NHL:

Nhal_1229

NWA:

Nwat_1362

NWR:	E3U44_17160

NTT:

TAO_1159

NTG:	NSCAC_0661(degT)

HHC:	M911_05415

EBS:	ECTOBSL9_2450

TGR:

Tgr7_1173

TKM:

TK90_1483

TNI:	TVNIR_1896

TTI:	THITH_07045

TVR:

TVD_07215

SPIZ:

GJ672_04795

SHAI:

LMH63_10160

APRS:

BI364_10660

AAEO:

BJI67_06360

AFY:	BW247_09085

NAX:	HC341_10430

WEZ:	IC757_04795

ENW:	MJO57_27760

ENG:	O2T12_02310

EMP:	EZMO1_4730(gdpPS)

CBAA:

SRAA_0734(degT)

CBAB:

SMCB_1317(degT)

SHD:	SUTH_00154

AFR:

AFE_1458

AFE:	Lferr_1174

ACU:

Atc_0855

ACZ:	Acaty_c0838

AFI:	Acife_1310

AFJ:	AFERRID_22810

ATX:	GCD22_02122(degT)

AFP:	K1Y48_00335

ACIY:

MQE22_07345

GSU:	GSU2262(gnnB)

GSK:	KN400_2208(gnnB)

GME:	Gmet_2351(gnnB)

GPI:	GPICK_10475

GAO:	A2G06_06025

GBZ:	JZM60_15885

GEF:	FO488_02965

GLO:

Glov_0766

TAMM:

GEAMG1_0713(degT)

GSB:	GSUB_10435

GHC:	L9S41_10630

PCA:	Pcar_1257(gnnB)

PACE:

A6070_05020

PPD:

Ppro_3023

DVE:	DESUT3_22740(gnnB)

SMAO:

CAG99_19625

GLJ:

GKIL_2326

EMAI:

KZP23_20730

ALGO:

GYM62_11370

NTI:	DNFV4_02982

» show all

Reference

1 [PMID:15044494]

Authors

Sweet CR, Ribeiro AA, Raetz CR.

Title

Oxidation and transamination of the 3"-position of UDP-N-acetylglucosamine by enzymes from Acidithiobacillus ferrooxidans. Role in the formation of lipid a molecules with four amide-linked acyl chains.

Journal

J Biol Chem 279:25400-10 (2004)
DOI:10.1074/jbc.M400596200

Sequence

[afr:AFE_1458]

Other DBs

ExplorEnz - The Enzyme Database:

2.6.1.122

IUBMB Enzyme Nomenclature:

2.6.1.122

ExPASy - ENZYME nomenclature database:

2.6.1.122

BRENDA, the Enzyme Database:

2.6.1.122

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (201)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (78)   
   KEGG MGENES (122)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (4)   
   InterPro (4)   
All databases (212)   

Download RDF

DBGET integrated database retrieval system