Entry Name kynurenine---glyoxylate transaminase;
Class Transferases;BRITE hierarchy
Sysname L-kynurenine:glyoxylate aminotransferase (cyclizing)
Reaction(IUBMB) (1) L-kynurenine + glyoxylate = kynurenate + glycine + H2O (overall reaction) [RN:
R12692 ];
(1a) L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine [RN:
R01957 ];
(1b) 4-(2-aminophenyl)-2,4-dioxobutanoate = kynurenate + H2O (spontaneous) [RN:
R03445 ];
(2) 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O (overall reaction) [RN:
R12693 ];
(2a) 3-hydroxy-L-kynurenine + glyoxylate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine [RN:
R12694 ];
(2b) 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate = xanthurenate + H2O (spontaneous) [RN:
R03954 ]
Reaction(KEGG) Substrate L-kynurenine [CPD:
C00328 ];
glyoxylate [CPD:
C00048 ];
4-(2-aminophenyl)-2,4-dioxobutanoate [CPD:
C01252 ];
3-hydroxy-L-kynurenine [CPD:
C03227 ];
4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate [CPD:
C05645 ]
Product kynurenate [CPD:
C01717 ];
glycine [CPD:
C00037 ];
H2O [CPD:
C00001 ];
4-(2-aminophenyl)-2,4-dioxobutanoate [CPD:
C01252 ];
xanthurenate [CPD:
C02470 ];
4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate [CPD:
C05645 ]
Comment This enzyme, characterized from animals, belongs to a family of aminotransferases some members of which can use other amino acceptors (cf. EC
2.6.1.7 , kynurenine---oxoglutarate transaminase). The products, 4-(2-aminophenyl)-2,4-dioxobutanoate and 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate, are converted to kynurenate and xanthurenate, respectively, by spontaneous reactions.
History EC 2.6.1.63 created 1983
Reference Authors Harada I, Noguchi T, Kido R.
Title Purification and characterization of aromatic-amino-acid-glyoxylate aminotransferase from monkey and rat liver.
Journal Reference 2
Authors Harada, I.
Title [Glucagen inducible kynurenine aminotransferase.].
Journal Wakayama Igaku 31:61-68 (1980)
Reference Authors Han Q, Fang J, Li J.
Title 3-Hydroxykynurenine transaminase identity with alanine glyoxylate transaminase. A probable detoxification protein in Aedes aegypti.
Journal Sequence Reference Authors Rossi F, Lombardo F, Paglino A, Cassani C, Miglio G, Arca B, Rizzi M.
Title Identification and biochemical characterization of the Anopheles gambiae 3-hydroxykynurenine transaminase.
Journal Sequence Other DBs ExplorEnz - The Enzyme Database: 2.6.1.63
ExPASy - ENZYME nomenclature database: 2.6.1.63
