KEGG ENZYME: 2.6.1.77

ENZYME: 2.6.1.77

Entry

EC 2.6.1.77                 Enzyme

Name

taurine---pyruvate aminotransferase;
Tpa

Class

Transferases;
Transferring nitrogenous groups;
Transaminases

Sysname

taurine:pyruvate aminotransferase

Reaction(IUBMB)

taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde [RN:R05652]

Reaction(KEGG)

R05652

Substrate

taurine [CPD:C00245];
pyruvate [CPD:C00022]

Product

L-alanine [CPD:C00041];
2-sulfoacetaldehyde [CPD:C00593]

Comment

The enzyme from the bacterium Bilophila wadsworthia requires pyridoxal 5'-phosphate as a cofactor, and catalyses a reversible reaction that starts an anaerobic taurine degradation pathway. beta-Alanine is also a significant amino group donor. The enzyme from the bacterium Pseudomonas denitrificans PD1222 can also use hypotaurine, producing 2-sulfinoacetaldehyde, which spontaneously hydrolyses to sulfite and acetaldehyde. Unlike, EC 2.6.1.55, taurine---2-oxoglutarate transaminase, 2-oxoglutarate cannot serve as an acceptor for the amino group.

History

EC 2.6.1.77 created 2003

Pathway

ec00430

Taurine and hypotaurine metabolism

ec01100

Metabolic pathways

Orthology

K03851

taurine-pyruvate aminotransferase

Genes

VNA:	PN96_16085

VEJ:	VEJY3_24191

VAS:	GT360_16445

VAQ:	FIV01_09475(tpa)

PGB:	H744_1c1564

PCQ:	PcP3B5_40420(tpa_3)

PMAO:

PMYSY11_0934(hpa_tpa)

COLW:

A3Q33_11510

AGQ:	LQZ07_03190

PIN:

Ping_0051

MBRG:

PVT68_13560

AFUS:

EYZ66_13865

GAI:	IMCC3135_11690(tpa)

WOC:	BA177_02200

HHH:	CLM76_04195

MPC:	Mar181_2033

MFOI:

JSY38_11935

MARS:

A8C75_19765

MRZ:	KDW95_19210

NJP:	NEJAP_1517 NEJAP_3251

TSN:	W908_04080

BPE:

BP0721

BPC:

BPTD_0724

BPER:

BN118_0083

BPET:

B1917_3102

BPEU:

Q425_33090

BPAR:

BN117_1002

BPA:

BPP3675

BBH:	BN112_4293

BBR:

BB4110

BBM:	BN115_3799

BBX:	BBS798_3903

HOE:	IMCC20628_04174

KMN:	HW532_15990

RBAN:

J2J98_22620

NEN:	NCHU2750_31190(tpa)

MAQU:

Maq22A_c21465(bioA)

MEE:	DA075_14980

MIND:

mvi_53040(yhxA)

LABP:

FJ695_09660

ACUT:

MRB58_08210

SIL:	SPO0673(tpa)

SIT:	TM1040_0159

RUA:	D1823_10950

RUT:	FIU92_02275(tpa1)

RCON:

K3740_03640

RDE:	RD1_0981(tpa)

RLI:	RLO149_c001900(tpa)

RPON:

G3256_17135

DSH:	Dshi_2042(tpa)

KVL:	KVU_0494(yhxA) KVU_0941(tpa)

KVU:

EIO_1453

KRO:	BVG79_01142(tpa)

PGA:	PGA1_c28770(tpa)

PGL:	PGA2_c26710(tpa)

PGD:

Gal_00552

PHP:	PhaeoP97_00629(tpa)

PPIC:

PhaeoP14_02649(tpa)

PHQ:	D1820_09080

OAT:	OAN307_c06270(tpa)

OAR:	OA238_c35800(tpa)

OTM:	OSB_27890(tpa_2)

LMD:	METH_14885

LEJ:	ETW24_16500

LAQU:

R2C4_14985

LEV:	ETW23_02430

LCAE:

K3721_02060

CID:

P73_3057

CEH:	CEW89_00680

MALG:

MALG_00569

YPAC:

CEW88_11285

YAN:	AYJ57_04665

TPRO:

Ga0080559_TMP1161

PABY:

Ga0080574_TMP3122

SUAM:

BOO69_01270

SULZ:

C1J03_02125

SULI:

C1J05_19075

SULD:

B5M07_15800

SPOT:

G6548_03215

SMED:

JNX03_11915

SINL:

DSM14862_03101(tpa)

SFAV:

PL335_14860

SUAL:

KDD17_13250

SDUB:

R1T39_09670

SPSE:

SULPSESMR1_03483(tpa)

TOM:	BWR18_14615

RMM:	ROSMUCSMR3_02376(tpa)

ROK:	RAK1035_0806

RID:	RIdsm_05064(tpa_5)

ROM:	EI983_01930

ROH:	FIU89_00700(tpa1)

RPEL:

N7U68_14700

AHT:	ANTHELSMS3_02105

SAGU:

CDO87_04525

THAA:

CFI11_17995

ROT:	FIV09_01645(tpa1)

RMH:	LVO79_14855

MALU:

KU6B_42160(yhxA)

TGL:	HFZ77_15445

PALX:

GQA70_15780

LSAL:

KBK07_02915

LALG:

LentiSH36_00033(tpa)

TRY:	QF118_18805

PLCG:

RVY76_10765

RSP:	RSP_0943(yhxA)

RSH:	Rsph17029_2602

RSQ:	Rsph17025_2972

RSK:	RSKD131_2333

CAZT:

LV780_13015

RCP:	RCAP_rcc02240(tpa)

RHP:	LPB142_00195

RBL:	B6K69_03585

PDE:

Pden_4273

PAMI:

JCM7686_0076

PYE:	A6J80_08490

PAMN:

JCM7685_1928

PAAK:

FIU66_13785

PKD:	F8A10_12975

PPAN:

ESD82_17110(tpa)

PMEH:

JWJ88_14275

PSEW:

JHW44_17615

PFIS:

JHX87_16640

PALP:

JHW40_21715

PVER:

E3U25_11910(tpa)

PFEO:

E3U26_00920(tpa)

PTP:	RCA23_c01520(tpa)

RHC:

RGUI_0795

RMB:	K529_018320

TSCO:

R1T40_13410

DON:	BSK21_02220

RBZ:	B9057_11330

TEC:	AKL02_013105

LVS:	LOKVESSMR4R_02315(tpa)

RBG:	BG454_06905

GEH:	HYN69_10755

GFU:	KM031_14015

TAW:	EI545_18660

SEDI:

EBB79_18515

PPSO:

QPJ95_09650

HML:	HmaOT1_18115

PSEB:

EOK75_19920

PPRU:

FDP22_21760

PAED:

G5B38_09475

PALW:

PSAL_028160(hpa_tpa)

PSHQ:

F3W81_15520 F3W81_16595

CACT:

HZ995_05005

THAS:

C6Y53_15175

FAP:	GR316_08615 GR316_12565

NSM:	JO391_03890

ACRO:

K3J57_04290

SINR:

O5O51_01240

AMYL:

QBD29_09085

FAQ:	G5B39_16020

GXL:

H845_1617

RGI:	RGI145_19730

ROS:	CTJ15_00415

RMUC:

FOB66_02175

RFL:	Rmf_00060(yhxA)

ATI:	AL072_26690

AZM:	DM194_19010

AOZ:	HUE56_07530

AZS:	E6C72_15870

NACI:

NUH88_17940

THAR:

T8K17_15510

TMO:

TMO_c0442

SNEA:

NBZ79_08440

KOZ:	KFF44_12560

DDS:

Ddes_0218

DFI:	AXF13_01545

DEF:	CNY67_13690

DVM:

DvMF_0516

CLIH:

KPS_000636

TMUR:

JBF11_05035

DOA:	AXF15_02700

DPS:	DP0541 DP0545

DLM:	DPPLL_30410(yhxA)

DEO:	CAY53_09710

DBK:	DGMP_28330(yhxA)

DOV:	DSCO28_21000

DWD:	DSCW_03190(yhxA)

DALK:

DSCA_12790

DEK:	DSLASN_46250

BSU:	BSU09260(yhxA)

BSR:

I33_1053

BSL:

A7A1_3801

BSH:	BSU6051_09260(yhxA)

BSY:	I653_04655

BSUT:

BSUB_01021(yhxA)

BSUL:

BSUA_01021(yhxA)

BSUS:

Q433_05265

BSO:	BSNT_07358(yhxA)

BSN:	BSn5_16510

BSQ:	B657_09260(yhxA)

BSX:	C663_0949(yhxA)

BSP:	U712_04715

BSS:	BSUW23_04675(yhxA)

BST:

GYO_1214

BIT:	BIS30_15320

BAY:	RBAM_009520

BAQ:	BACAU_0912(yhxA)

BYA:	BANAU_0857(yhxA)

BAMP:

B938_04545

BQY:	MUS_0963(yhxA)

BAML:

BAM5036_0854(yhxA)

BAMA:

RBAU_0915(yhxA)

BAMN:

BASU_0891(yhxA)

BAMB:

BAPNAU_2850(yhxA)

BAMT:

AJ82_05330

BAMY:

V529_08870(yhxA)

BMP:	NG74_00959(tpa_1)

BAO:	BAMF_1022(yhxA)

BAZ:	BAMTA208_04320(yhxA)

BQL:	LL3_01007(yhxA)

BXH:	BAXH7_00902(yhxA)

BAMI:

KSO_015115

BAMC:

U471_09340

BAMF:

U722_04800

BSIA:

CWD84_17010

BAE:	BATR1942_02230

BVM:	B9C48_04745

BSON:

S101395_03844

BHT:	DIC78_05020

BMOJ:

HC660_09850(yhxA)

BTEQ:

G4P54_04935

BIQ:	AN935_04845

BSTR:

QI003_05075(yhxA)

BAN:

BA_1636

BAR:

GBAA_1636

BAT:

BAS1519

BAH:	BAMEG_2954

BAI:

BAA_1709

BAX:	H9401_1542

BANT:

A16_16770

BANR:

A16R_16950

BANS:

BAPAT_1551

BANH:

HYU01_08270

BANV:

DJ46_455

BCE:

BC1610

BCA:

BCE_1727

BCZ:	BCE33L1481(bioA)

BCR:	BCAH187_A1778

BCB:	BCB4264_A1673

BCU:	BCAH820_1704

BCG:	BCG9842_B3671

BCQ:	BCQ_1668(bioA)

BCX:

BCA_1667

BAL:	BACI_c16570(bioA1)

BNC:

BCN_1588

BCF:

bcf_08105

BCER:

BCK_00395

BCEF:

BcrFT9_01357

BCY:	Bcer98_1331

BTK:	BT9727_1491(bioA)

BTL:	BALH_1448(bioA)

BTB:	BMB171_C1455

BTT:

HD73_1844

BTHR:

YBT1520_09185

BTHI:

BTK_09360

BTC:	CT43_CH1536

BTF:	YBT020_08700

BTM:	MC28_0855 MC28_2415

BTG:	BTB_c16490(yhxA)

BTI:

BTG_12680

BTN:	BTF1_05755

BTHT:

H175_ch1555

BTHU:

YBT1518_09350

BTW:

BF38_2830

BTHY:

AQ980_21750

BWE:	BcerKBAB4_1524 BcerKBAB4_3172

BWW:	bwei_1477(tpa) bwei_3380(tpa)

BMYO:

BG05_2542 BG05_4284

BTY:	Btoyo_0519 Btoyo_4240

BMYC:

DJ92_4255 DJ92_470

BBY:	CY96_07215

BWD:	CT694_08880

BTRO:

FJR70_00735

BMOB:

MLA2C4_08405

BNT:	GSN03_08150 GSN03_16365

BPAC:

LMD38_18350

BPAN:

NLJ82_08295

BALU:

QRY64_10475

BPU:

BPUM_0880

BPUM:

BW16_04795

BPUS:

UP12_04780

BIF:	N288_11940

BMET:

BMMGA3_06920(yhxA)

BGY:

BGLY_1018

BWH:	A9C19_17095

BXI:	BK049_03520

BALT:

CFN77_04705

BAER:

BAE_12265

BSAF:

BSL056_04655

BFD:	NCTC4823_01351(tpa_5) NCTC4823_02711(tpa_6)

BSHI:

LGQ02_11045

BBAD:

K7T73_04730 K7T73_07315

BCAB:

EFK13_05275

BRY:	M0696_05240

BJS:

MY9_1022

BACI:

B1NLA3E_11150

GST:	HW35_01140

BACW:

QR42_04590

BACP:

SB24_05120

BACB:

OY17_07440

BACY:

QF06_03570

BACL:

BS34A_10460(yhxA)

BALM:

BsLM_0965

BACS:

AUL54_05850

BACQ:

DOE78_13265

BACA:

FAY30_14100 FAY30_25625

BAQU:

K6959_02600

BZH:	NF868_03980

BHAI:

KJK41_09835

BCAO:

LC087_04075

BARD:

QRY57_09800 QRY57_17265

BAEI:

RE735_14815

BCO:	Bcell_1318

BHK:	B4U37_15635

BCOH:

BC6307_05660 BC6307_15990

BMQ:

BMQ_4417

BMD:

BMD_4403

BMH:	BMWSH_0815

BMEG:

BG04_1334

BEO:	BEH_08240 BEH_19305

BFX:	BC359_05665

PKS:	IE339_18395

BCL:

ABC3786

BLE:	BleG1_1854

SHUA:

PQ477_18155

BGI:	BGM20_19910

BPF:	BpOF4_09055

BON:	A361_16950

BKO:	CKF48_20610

CGOT:

J1899_05040

CSUA:

IM538_12215

CFIR:

NAF01_15090

CSPG:

LS684_20830

OCN:	CUC15_19195

OJD:	NP439_03395 NP439_09765

OON:	NP440_05060 NP440_09745

GKA:

GK1427

GTE:	GTCCBUS3UF5_16600

GTK:	GT3570_06840

GTM:	GT3921_12175

GLI:	GLN3_00615

BCAL:

CWI35_03090

GTN:

GTNG_1286

GWC:	GWCH70_1320

GYC:	GYMC61_2218

GYA:	GYMC52_1346

GCT:	GC56T3_2120

GMC:	GY4MC1_2463

GGH:	GHH_c13390(yhxA)

GJF:	M493_07270

GEA:	GARCT_01455(tpa)

GEL:	IB49_17520

GSE:	GT50_00930

GSR:	GS3922_09480

GZA:	IC807_02995

GTH:	Geoth_2505

PTL:	AOT13_10110

PCAL:

BV455_00420(tpa)

PARG:

PspKH34_24170(bioA_2)

ANM:

GFC28_986

AAMY:

GFC30_2204

ANL:

GFC29_641

AND:	GRQ40_07850

ACAI:

ISX45_04860

ASED:

IRT44_15600

LSP:	Bsph_0922 Bsph_2005 Bsph_2223

LGY:	T479_02320

LFU:	HR49_15100 HR49_16385 HR49_21455

LYS:	LBYS11_02380 LBYS11_07100 LBYS11_07965

LYB:	C3943_03030

LYZ:	DCE79_15110

LPAK:

GDS87_02470

LAGR:

FJQ98_03095

LMAC:

I6G82_16040

LYC:	FH508_0002225

LCAP:

ICJ70_16250 ICJ70_17135 ICJ70_22085

LIU:	OU989_02170 OU989_07000 OU989_07925

HHD:	HBHAL_2651

HLI:

HLI_04685

HNZ:	P9989_04280 P9989_17480

HSHI:

MUO14_09665 MUO14_15240 MUO14_17615

VIR:	X953_14880

VHL:	BME96_14205

VIL:	CFK37_09915 CFK37_10510

VNE:	CFK40_05260 CFK40_05890

VPN:	A21D_02472(tpa)

VNT:	OLD84_06355

VIK:	KFZ58_06130 KFZ58_15090

LAO:	AOX59_17185 AOX59_17360

LEX:	Len3610_11490

FEC:	QNH15_13820

BSJ:	UP17_09745 UP17_13145 UP17_14580

BMUR:

ABE28_010400 ABE28_012275

PBUT:

DTO10_00525 DTO10_23550 DTO10_26010

PPSR:

I6J18_03545

PFRI:

L8956_10770 L8956_13440

RAX:	KO561_18190

PSYO:

PB01_12610

GCS:	MUN88_00205

GSM:	MUN87_17480 MUN87_19815 MUN87_19825

RUE:	DT065_13485

SALE:

EPH95_13725

SCIB:

HUG20_01775

SCIA:

HUG15_02910

NMK:	CHR53_13300 CHR53_16990

NDT:	L1999_10515

NCM:	QNK12_17350

NNV:	QNH39_13930

MEKU:

HUW50_23990

MDG:	K8L98_09770

MLIT:

KDJ21_024155

BLEN:

NCTC4824_02911(tpa)

BVQ:	FHE72_10400

RAZ:	U9J35_10465

BAG:

Bcoa_0555

BOU:	I5818_13050

CTHU:

HUR95_01420

GAJ:	MY490_16380

SFOR:

QNH23_02720 QNH23_09105

ECTO:

MUG87_03300

ALKG:

MOJ78_16390

PHJ:	LC071_00910

DOM:	RRU94_03670 RRU94_03695

BBE:	BBR47_32450

BFM:	BP422_11355

BAGR:

BA6348_14185

BCHS:

JNE38_16970

BCOP:

JD108_10800

BPAB:

PSE45_15370

BHUI:

LOK74_07365

BAYD:

BSPP4475_09765

BBOR:

RFB14_12165

BRUM:

NDK47_12835

PJD:	Pjdr2_3936

PMS:	KNP414_02471(yhxA)

PMQ:	PM3016_2727

PMW:

B2K_13815

PSAB:

PSAB_23050

PDU:	PDUR_26250

PBD:	PBOR_26460 PBOR_34365

PGM:	PGRAT_30730

POD:	PODO_29205

PAEN:

P40081_35700

PAEF:

R50345_29320

PAEQ:

R50912_32310

PSTE:

PSTEL_25730

PAEA:

R70723_31155

PAEE:

R70331_29910

PAEH:

H70357_33425

PAEJ:

H70737_28960

PBJ:	VN24_02850

PRI:	PRIO_6435(yhxA)

PSON:

JI735_06895

PNP:	IJ22_07270

PXL:	BS614_00435

PYG:	AWM70_15930

PSWU:

SY83_21850

PDH:	B9T62_30080

PALB:

EJC50_22530

PBAC:

HUB98_14615

PRZ:	GZH47_23950

PSOP:

KP014_01655

PTRI:

KDC22_31290

PTJ:	JRJ22_27625

PKA:	PQ456_03140

PMAH:

PTQ21_02665

PHK:	SK066_20580

PNK:	AASFL403_16025

PPAB:

KET34_31615

ANX:	ACH33_08470 ACH33_09925

ATHE:

K3F53_09095 K3F53_10350

AAC:

Aaci_2668

AAD:

TC41_2977

AACO:

K1I37_05775

ACUR:

JZ785_22425

ACYC:

JI721_11595

BTS:

Btus_3087

KYR:	CVV65_15280

SIV:

SSIL_0757

SSIL:

SOLI23_14920

SOB:	CSE16_07260

KUR:	ASO14_1690

SPSY:

AZE41_14385 AZE41_20715

SPOR:

SporoP33_12160

SURE:

SporoP32a_12830

SPAE:

E2C16_12375

SURL:

BI350_00255

PANC:

E2636_14835

VIJ:	JNUCC6_00865

NTR:	B0W44_07245

PABS:

JIR001_12150(yhxA)

CMIC:

caldi_12300(yhxA)

DDL:	Desdi_0270

DRU:	Desru_0589

AACX:

DEACI_1230

NCD:	ACONDI_01914(tpa)

STED:

SPTER_40040(tpa)

ACIT:

HPK19_11250

NEX:	NE857_07355

RRD:	RradSPS_2821

» show all

Reference

1 [PMID:11082195]

Authors

Laue H, Cook AM.

Title

Biochemical and molecular characterization of taurine:pyruvate aminotransferase from the anaerobe Bilophila wadsworthia.

Journal

Eur J Biochem 267:6841-8 (2000)
DOI:10.1046/j.1432-1033.2000.01782.x

Sequence

[ag:AAG50296]

Reference

2 [PMID:12471498]

Authors

Cook AM, Denger K.

Title

Dissimilation of the C2 sulfonates.

Journal

Arch Microbiol 179:1-6 (2002)
DOI:10.1007/s00203-002-0497-0

Reference

3 [PMID:11728723]

Authors

Masepohl B, Fuhrer F, Klipp W.

Title

Genetic analysis of a Rhodobacter capsulatus gene region involved in utilization of taurine as a sulfur source.

Journal

FEMS Microbiol Lett 205:105-11 (2001)
DOI:10.1111/j.1574-6968.2001.tb10932.x

Reference

4 [PMID:23603744]

Authors

Felux AK, Denger K, Weiss M, Cook AM, Schleheck D

Title

Paracoccus denitrificans PD1222 utilizes hypotaurine via transamination followed by spontaneous desulfination to yield acetaldehyde and, finally, acetate for growth.

Journal

J Bacteriol 195:2921-30 (2013)
DOI:10.1128/JB.00307-13

Other DBs

ExplorEnz - The Enzyme Database:

2.6.1.77

IUBMB Enzyme Nomenclature:

2.6.1.77

ExPASy - ENZYME nomenclature database:

2.6.1.77

BRENDA, the Enzyme Database:

2.6.1.77

CAS:	51901-18-9

DBGET integrated database retrieval system