KEGG   ENZYME: 2.6.1.80
Entry
EC 2.6.1.80                 Enzyme                                 
Name
nicotianamine aminotransferase;
NAAT;
NAAT-I;
NAAT-II;
NAAT-III;
nicotianamine transaminase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
nicotianamine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
nicotianamine + 2-oxoglutarate = 3''-deamino-3''-oxonicotianamine + L-glutamate [RN:R07277]
Reaction(KEGG)
R07277
Substrate
nicotianamine [CPD:C05324];
2-oxoglutarate [CPD:C00026]
Product
3''-deamino-3''-oxonicotianamine [CPD:C15486];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. This enzyme is produced by grasses. They secrete both the nicotianamine and the transaminated product into the soil around them. Both compounds chelate iron(II) and iron(III); these chelators, called mugineic acid family phytosiderophores, are taken up by the grass, which is thereby supplied with iron.
History
EC 2.6.1.80 created 2005
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K14271  nicotianamine aminotransferase
Genes
OSA9267778
DOSAOs02t0306401-00(Os02g0306401)
OBR102711499
OGL127764751
BDI100831451
ATS109747034 109747035
TDC119283036 119283052 119348169 119348182
TAES123059564 123093828 123136500 123154591 123182310 123182311
TUA125521156 125536048
LPER127318045 127334708
LRD124678253 124705925
SBI110433086 8081150
ZMA100191283 100193424
SITA101775023
SVS117847656
PVIR120655531 120655609 120699474
PHAI112878152
 » show all
Reference
1
  Authors
Kanazawa, K., Higuchi, K., Nishizawa, N.-K., Fushiya, S., Chino, M. and Mori, S.
  Title
Nicotianamine aminotransferase activities are correlated with the phytosiderophore secretions under Fe-deficient conditions in Gramineae.
  Journal
J Exp Bot 45:1903-1906 (1994)
Reference
2  [PMID:10557244]
  Authors
Takahashi M, Yamaguchi H, Nakanishi H, Shioiri T, Nishizawa NK, Mori S
  Title
Cloning two genes for nicotianamine aminotransferase, a critical enzyme in iron acquisition (Strategy II) in graminaceous plants.
  Journal
Plant Physiol 121:947-56 (1999)
DOI:10.1104/pp.121.3.947
  Sequence
Reference
3  [PMID:14699112]
  Authors
Schaaf G, Ludewig U, Erenoglu BE, Mori S, Kitahara T, von Wiren N.
  Title
ZmYS1 functions as a proton-coupled symporter for phytosiderophore- and nicotianamine-chelated metals.
  Journal
J Biol Chem 279:9091-6 (2004)
DOI:10.1074/jbc.M311799200
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.80
IUBMB Enzyme Nomenclature: 2.6.1.80
ExPASy - ENZYME nomenclature database: 2.6.1.80
BRENDA, the Enzyme Database: 2.6.1.80
CAS: 154907-64-9

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