Entry
Name
arginine---pyruvate transaminase;
arginine:pyruvate transaminase;
AruH;
ATase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-arginine:pyruvate aminotransferase
Reaction(IUBMB)
L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine [RN:
R08197 ]
Reaction(KEGG)
Substrate
Product
5-guanidino-2-oxopentanoate [CPD:
C03771 ];
L-alanine [CPD:
C00041 ]
Comment
A pyridoxal-phosphate protein. While L-arginine is the best substrate, the enzyme exhibits broad substrate specificity, with L-lysine, L-methionine, L-leucine, L-ornithine and L-glutamine also able to act as substrates, but more slowly. Pyruvate cannot be replaced by 2-oxoglutarate as amino-group acceptor. This is the first catalytic enzyme of the arginine transaminase pathway for L-arginine utilization in Pseudomonas aeruginosa. This pathway is only used when the major route of arginine catabolism, i.e. the arginine succinyltransferase pathway, is blocked.
History
EC 2.6.1.84 created 2007
Pathway
ec00330 Arginine and proline metabolism
Orthology
K12252 arginine:pyruvate transaminase
Genes
PAEB : NCGM1900_5724(aspC)
PRE : PCA10_09720 PCA10_40340(aspC)
PMUI : G4G71_03200 G4G71_27455
PNT : G5B91_05490 G5B91_32200
PFL : PFL_2715(aruH) PFL_3354 PFL_5024
PPRC : PFLCHA0_c27760(aspC2) PFLCHA0_c33840(aspC3)
PPRO : PPC_2762(aruH) PPC_3378
PMAN : OU5_0567 OU5_1090 OU5_1975
PPUU : PputUW4_02429 PputUW4_02748 PputUW4_03176
PDR : H681_05055 H681_24930
PKC : PKB_0124(aspc1) PKB_4718
PCZ : PCL1606_27200 PCL1606_34600
PCHP : C4K32_2707 C4K32_3428
PALK : PSAKL28_23960 PSAKL28_27660
PSEM : TO66_13290 TO66_17300
PSOS : POS17_2711(aruH) POS17_3331
PSET : THL1_1027 THL1_3997
PUM : HGP31_15755 HGP31_15870 HGP31_16595
POJ : PtoMrB4_51000(aruH_2)
PLAL : FXN65_04505 FXN65_08195
PSEP : C4K39_2740 C4K39_4608 C4K39_5322
PPII : QL104_17230 QL104_17835 QL104_25705
PAZE : KSS91_13350 KSS91_15425 KSS91_17540
PORY : EJA05_14670 EJA05_15310
PTK : EXN22_14850 EXN22_15085
PTW : TUM18999_04140(aruH)
PTAE : NCTC10697_02325(aspC_1)
PIZ : LAB08_R27020 LAB08_R27910 LAB08_R28150
PSIH : LOY51_14300 LOY51_15670
PKJ : Q1W70_03580 Q1W70_23965
PHOM : KJF94_09175 KJF94_12250
PDEN : F1C79_24140 F1C79_30200
MICC : AUP74_01586(aruH_1) AUP74_02850(aruH_2)
MAGA : Mag101_09640 Mag101_13965
MHYD : GTQ55_04695 GTQ55_10565
GAI : IMCC3135_11970(aruH_1)
BGE : BC1002_4015 BC1002_6946
PSPW : BJG93_26095 BJG93_27760
PDIO : PDMSB3_1932.1(aruH)
SMEL : SM2011_c02262(aspC)
SFD : USDA257_c01790(aspC2)
SAME : SAMCFNEI73_Ch0558(aspC)
NGL : RG1141_CH32880(aruH)
NEN : NCHU2750_30720(aruH)
SIL : SPO2132(aspC-3) SPOA0066
RUA : D1823_04845 D1823_17940
RUT : FIU92_08160(aruH1) FIU92_13435(aruH2)
RCON : K3740_02950 K3740_15065
RLI : RLO149_c024100(aspC)
YPAC : CEW88_06400 CEW88_20105
SINL : DSM14862_02675(aruH)
SPSE : SULPSESMR1_01753(aruH)
RMM : ROSMUCSMR3_01198(aruH)
AHT : ANTHELSMS3_03017(aruH)
LVS : LOKVESSMR4R_02264(aruH)
» show all
Taxonomy
Reference
Authors
Yang Z, Lu CD.
Title
Characterization of an arginine:pyruvate transaminase in arginine catabolism of Pseudomonas aeruginosa PAO1.
Journal
Sequence
Reference
Authors
Yang Z, Lu CD
Title
Functional genomics enables identification of genes of the arginine transaminase pathway in Pseudomonas aeruginosa.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.84
ExPASy - ENZYME nomenclature database: 2.6.1.84