KEGG   ENZYME: 2.6.1.89
Entry
EC 2.6.1.89                 Enzyme                                 
Name
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase;
TylB;
TDP-3-keto-6-deoxy-D-glucose 3-aminotransferase;
TDP-3-dehydro-6-deoxy-D-glucose 3-aminotransferase;
dTDP-3-keto-6-deoxy-D-glucose 3-aminotransferase;
dTDP-3-dehydro-6-deoxy-D-glucose 3-aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose:2-oxoglutarate aminotransferase
Reaction(IUBMB)
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate = dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate [RN:R06423]
Reaction(KEGG)
R06423
Substrate
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose;
2-oxoglutarate [CPD:C00026]
Product
dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose [CPD:C11908];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. The reaction occurs in the reverse direction. The enzyme is involved in biosynthesis of D-mycaminose.
History
EC 2.6.1.89 created 2011
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19854  dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase
K24250  dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase
Genes
SAMB: SAM23877_5622(srm15)
SALJ: SMD11_1659
SCAE: IHE65_08875
Reference
1  [PMID:17209568]
  Authors
Melancon CE 3rd, Hong L, White JA, Liu YN, Liu HW
  Title
Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase from the D-mycaminose biosynthetic pathway of Streptomyces fradiae: in vitro activity and substrate specificity studies.
  Journal
Biochemistry 46:577-90 (2007)
DOI:10.1021/bi061907y
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.89
IUBMB Enzyme Nomenclature: 2.6.1.89
ExPASy - ENZYME nomenclature database: 2.6.1.89
BRENDA, the Enzyme Database: 2.6.1.89

  All links  
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (7)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (5)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (5)   
   RefSeq(nuc) (5)   
All databases (29)   

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