neomycin C [CPD:C15652];
2-oxoglutarate [CPD:C00026]
Product
6'''-deamino-6'''-oxoneomycin C [CPD:C17589];
L-glutamate [CPD:C00025]
Comment
The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. Works in combination with EC 1.1.3.44, 6'''-hydroxyneomycin C oxidase, to replace the 6'''-hydroxy group of 6'''-deamino-6'''-hydroxyneomycin C with an amino group.
The enzyme, characterized from the bacterium Streptomyces fradiae, can also catalyse EC 2.6.1.93, neamine transaminase.