KEGG   ENZYME: 2.6.1.97
Entry
EC 2.6.1.97                 Enzyme                                 
Name
archaeosine synthase;
ArcS;
TgtA2;
MJ1022 (gene name);
glutamine:preQ0-tRNA amidinotransferase (incorrect)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-glutamine:7-cyano-7-carbaguanine aminotransferase
Reaction(IUBMB)
L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA
Substrate
L-glutamine [CPD:C00064];
7-cyano-7-carbaguanine15 in tRNA;
H2O [CPD:C00001]
Product
L-glutamate [CPD:C00025];
archaeine15 in tRNA
Comment
In Euryarchaeota the reaction is catalysed by ArcS [1,2]. In Crenarchaeota, which do not have an ArcS homologue, the reaction is catalysed either by a homologue of EC 6.3.4.20, 7-cyano-7-deazaguanine synthase that includes a glutaminase domain (cf. EC 3.5.1.2), or by a homologue of EC 1.7.1.13, preQ1 synthase [2]. The enzyme from the Euryarchaeon Methanocaldococcus jannaschii can also use arginine and ammonium as amino donors.
History
EC 2.6.1.97 created 2012
Orthology
K07557  archaeosine synthase alpha-subunit
Genes
BSONS101395_02370
MJAMJ_1022
MFEMefer_0631
MVUMetvu_0618
MFSMFS40622_1635
MIFMetin_0871
MJHJH146_0921
MESGMLAUSG7_0850(arcS)
MESAMLASG1_0911(arcS)
MIGMetig_0768
MMPMMP1595
MMQMmarC5_1814
MMXMmarC6_1075
MMZMmarC7_0842
MMDGYY_08830
MMAKMMKA1_18250
MMAOMMOS7_17070
MMADMMJJ_12410
MAEMaeo_1488
MVNMevan_0907
MVOMvol_1161
MOKMetok_0003
METFCFE53_03430
MTHMTH_1665
MMGMTBMA_c02440
MWOMWSIV6_0204(arcS1)
MTEEMTTB_14060
METCMTCT_1519
METEtca_01613
METZMETMT2_1496
METKFVF72_03335
MTHMFZP57_00910
METJFZP68_05920
MSTMsp_1063
METBAW729_10570
MEISPXD04_02305
MRUmru_0475
MSIMsm_0633
MEBAbm4_0249
MMILsm9_0339(tgtA)
MEYETL18_01460
MOLYLM1_0148
MAROMarbSA_09370
METVK4897_03730
MELMetbo_2039
MEWMSWAN_0599
METHMBMB1_0635
MFCBRM9_1603
MFIDSM1535_2297
MCUBMCBB_0612(arcS1)
MSUBBK009_01260
METNBK008_09705
METTCIT01_06985
METOCIT02_03765
MEMEHYG87_07690
MFEGGCM10025860_16510
MFVMfer_1055
MKAMK1084
AFUAF_0587
AFGAFULGI_00006620
APOArcpr_1822
AVEArcve_0757
ASTAsulf_00168
FPLFerp_1812
GACGACE_2024
GAHGAH_00618
PFUPF0071
PFIPFC_07845
PHOPH0135(PH0135)
PABPAB0082
PYNPNA2_0664
PYAPYCH_16080
PYSPy04_0227
PYCTQ32_00095
TKOTK2156
TONTON_1505
TGATGAM_2122
TSITSIB_1831
TBATERMP_01792
THEGQS_07960
THATAM4_168
THMCL1_1211
TLTOCC_09014
THSTES1_1781
TNUBD01_1969
TEUTEU_01525
TGYX802_02835 X802_03965
THVADU37_CDS19530
TCHCHITON_0277
TPEPA0127_04755
TPIEA7C91_04735
TGGA3K92_00095
TCEA3L02_06420
TBSA3L01_08380
THHCDI07_08375
TSLA3L11_01755
TTDA3L14_10755
TPRFA3L09_01940
TRLA3L10_07845
TPAFA3L08_01440
THYA3L12_04165
TICFH039_11935
TCQTIRI35C_2000
THEMFPV09_09575
THEIK1720_02045
PPACPAP_09270
MBAMbar_A0956
MBYMSBRM_0045
MBWMSBRW_0042
MBARMSBR2_0044
MBAKMSBR3_0025
MACMA_4632(tgt)
MMAMM_1292
MMAZMmTuc01_1339
MMJMSMAS_0023
MMACMSMAC_0023
MVCMSVAZ_0059
MEKMSKOL_0055
MLSMSLAZ_0022
METMMSMTP_0025
MEFMSWH1_0024
MEQMSWHS_0025
MSJMSSAC_0031
MSZMSSIH_0028
MSWMSSIT_0028
MTHRMSTHT_1801
MTHEMSTHC_1485
MHORMSHOH_0023
MFZAOB57_008265
MBUMbur_1772
MMETMCMEM_0029
MELOJ7W08_10180
MMHMmah_1951
MHAZBHR79_03880
MPOTBKM01_10005
MEVMetev_0035
MZHMzhil_0029
MPYMpsy_1799
MZIHWN40_01315
MMAVRE476_10415(arcS)
MSEBRE474_07020(arcS)
MHZMetho_2410
MEHFMmiHf6_12920
MEESMmiEs2_15340
MTPMthe_1661
MCJMCON_0338
MHIMhar_0738
MHUMhun_0351 Mhun_1119
MRTJKHC33_08530 KHC33_12540
MLAMlab_0587 Mlab_1208
MEMMemar_1286 Memar_1324
MBGBN140_2026(tgt1) BN140_2167
MEMAMMAB1_2626(tgt) MMAB1_2870
MCHKMchiMG62_14720
MSUMOH143_00655(arcS)
MRCR6Y96_03940(arcS)
MPIMpet_2092
MEFWF1737_02260
MFKE2N92_00280
MOUOU421_11410(arcS)
MESBL1S32_03300(arcS)
MANQL1994_07260(arcS)
MBNMboo_1314 Mboo_2194
MFOMetfor_1671
MPLMpal_1830
MPDMCP_1516
MEZMtc_1748
RCILRC280(tgt-1)
HALVNG_1957G(tgtA2)
HSLOE_3748R(arcS)
HANRLJ422_07880
HDLHALDL1_14730
HHBHhub_3274(arcS)
HAGSJT689_09215
HABOJRZ79_07625
HNOLT974_13170(arcS)
HLULT972_01615(arcS)
HALHHTSR_1955(tgtA2)
HHSRHSR6_2030(tgtA2)
HSUHLASF_1960(tgtA2)
HSFHLASA_1946(tgtA2)
HAHSHSRCO_2597
SALRFQU85_06370
HALREFA46_002225
HJEHacjB3_04675
HDOMUK72_01455(arcS)
HALXM0R89_03455(arcS)
HAXZM0R88_03670(arcS)
HAYCNGM10_11445(arcS)
HAXYNGM07_09190(arcS)
SALIL593_08915
SAIMK0C01_07485
HARAAArcS_1166
HMArrnAC3261(tgt)
HHIHAH_0506(tgt2)
HHNHISP_02620
HABSG26_10410
HTABVU17_02490
HALJG9465_17705
HSINKDQ40_11005
NPHNP_2506A(arcS)
NMONmlp_3874(arcS)
NHOHWV23_14540
NSALHWV07_18020
HUTHuta_2177
HTIHTIA_2062
HALAHrd1104_02870
HASVSVXHr_2403(arcS)
HABNHBNXHr_2399(arcS)
HMUHmuk_1433
HALZE5139_10320
HALLLC1Hm_0974(tgtA2)
HAZPGBQ70_10315
HALIBV210_11925
HSNDV733_03185
HDSHSR122_0704
HRRHZS55_07215
HPELHZS54_07980
HLTI7X12_06870
HARCHARCEL1_06355
SSAIN0B31_04315(arcS)
HAADMW046_01315(arcS)
HVOHVO_2008(arcS)
HMEHFX_2104
HGIABY42_09815
HALEG3A49_13040
HLSKU306_02350
HLNSVXHx_2609(tgt)
HBOHbor_06070
HAQDU484_04545
HAJDU500_04960
HAERDU502_02855
HRAEI982_10740
HLMDV707_02075
HALMFCF25_02280
HLAHlac_2157
HALPDOS48_10415
HALBEKH57_04580
HEZZEO776_07255
HALQHrr1229_011345
HSSJ7656_09165
HSAIHPS36_14575
HAZZKI388_04950
SRUBC2R22_19040
HAEhalTADL_2545
HALNB4589_012610
HALGHUG10_09560
HALUHUG12_06160
HMPK6T50_07360
HREK6T36_07130
HRMK6T25_08645
HACBHbl1158_13725(arcS)
HDFAArcSl_0264(tgtA2)
HAHHalar_1992
HTUHtur_0714
HSALJMJ58_05510
HAKZJ0X25_10775(arcS)
NMGNmag_2683(arcS)
HXAHalxa_3592
NATNJ7G_3957
NPENatpe_3151
NVRFEJ81_14825
NPLFGF80_13860
NAYHYG81_13890(arcS)
HALYHYG82_20030
HJTDVR14_05880
HLOJ0X27_03280
NGENatgr_1052
HRUHalru_0679
SAWLNGM29_15705(arcS)
HALVNGM15_06895(arcS)
NOUNatoc_0819
HLRHALLA_07165
HLCCHINAEXTREME01465
NAJB1756_06775
NAGAArcMg_0718
NANAArc1_2905
NARAQQ977_11150(arcS)
NBGDV706_03725
NASGCU68_09770
HDABB347_00665
MELUMTLP_07910
MEAMMU439_02525(arcS)
MEAEQEN48_07755(arcS)
TACTa0924
TVOTVG1126727(TVG1126727)
PTOPTO0724
FACFACI_IFERC01G1191
FAIFAD_0222
CDIVCPM_0742
TARTALC_01156
MAXMMALV_12000
MERMMINT_05520
MEARMpt1_c07520(arcS)
MEUZKRP56_06075
MARCAR505_0438
ABIAboo_0923
ACFAciM339_0081
IHOIgni_1353
IISEYM_03625
TPETpen_1279
NEQNEQ526
LOKILokiarch_13630(arcS)
LOBNEF87_001172
PSYTDSAG12_03283(arcS)
 » show all
Reference
1  [PMID:20129918]
  Authors
Phillips G, Chikwana VM, Maxwell A, El-Yacoubi B, Swairjo MA, Iwata-Reuyl D, de Crecy-Lagard V
  Title
Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA.
  Journal
J Biol Chem 285:12706-13 (2010)
DOI:10.1074/jbc.M110.102236
  Sequence
[mja:MJ_1022]
Reference
2  [PMID:22032275]
  Authors
Phillips G, Swairjo MA, Gaston KW, Bailly M, Limbach PA, Iwata-Reuyl D, de Crecy-Lagard V
  Title
Diversity of archaeosine synthesis in crenarchaeota.
  Journal
ACS Chem Biol 7:300-5 (2012)
DOI:10.1021/cb200361w
  Sequence
[mja:MJ_1022]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.97
IUBMB Enzyme Nomenclature: 2.6.1.97
ExPASy - ENZYME nomenclature database: 2.6.1.97
BRENDA, the Enzyme Database: 2.6.1.97

DBGET integrated database retrieval system