KEGG ENZYME: 2.6.99.1

ENZYME: 2.6.99.1

Entry

EC 2.6.99.1                 Enzyme

Name

dATP(dGTP)---DNA purinetransferase

Class

Transferases;
Transferring nitrogenous groups;
Transferring other nitrogenous groups

Sysname

dATP(dGTP):depurinated-DNA purine transferase

Reaction(IUBMB)

(1) dATP + depurinated DNA = deoxyribose triphosphate + DNA [RN:R03904];
(2) dGTP + depurinated DNA = deoxyribose triphosphate + DNA [RN:R07278]

Reaction(KEGG)

R03904 R07278

Substrate

dATP [CPD:C00131];
depurinated DNA [CPD:C02270];
dGTP [CPD:C00286]

Product

deoxyribose triphosphate [CPD:C12347];
DNA [CPD:C00039]

Comment

The purine residue is transferred on to the apurinic site forming a normal glycosylic bond. dATP reacts at sites of the double-stranded depurinated DNA that lack adenine, and dGTP at sites that lack guanine.

History

EC 2.6.99.1 created 1984

Reference

1 [PMID:218192]

Authors

Deutsch WA, Linn S.

Title

DNA binding activity from cultured human fibrolasts that is specific for partially depurinated DNA and that inserts purines into apurinic sites.

Journal

Proc Natl Acad Sci U S A 76:141-4 (1979)
DOI:10.1073/pnas.76.1.141

Reference

2 [PMID:375225]

Authors

Livneh Z, Elad D, Sperling J.

Title

Enzymatic insertion of purine bases into depurinated DNA in vitro.

Journal

Proc Natl Acad Sci U S A 76:1089-93 (1979)
DOI:10.1073/pnas.76.3.1089

Other DBs

ExplorEnz - The Enzyme Database:

2.6.99.1

IUBMB Enzyme Nomenclature:

2.6.99.1

ExPASy - ENZYME nomenclature database:

2.6.99.1

BRENDA, the Enzyme Database:

2.6.99.1

All links

Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
All databases (9)   

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