Entry
Name
pyridoxine 5'-phosphate synthase;
pyridoxine 5-phosphate phospho lyase;
PNP synthase;
PdxJ
Class
Transferases;
Transferring nitrogenous groups;
Transferring other nitrogenous groups
BRITE hierarchy
Sysname
1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing)
Reaction(IUBMB)
1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O [RN:
R05838 ]
Reaction(KEGG)
Substrate
1-deoxy-D-xylulose 5-phosphate [CPD:
C11437 ];
3-amino-2-oxopropyl phosphate [CPD:
C11638 ]
Product
Comment
In Escherichia coli, the cofactor pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC
1.2.1.72 (erythrose-4-phosphate dehydrogenase), EC
1.1.1.290 (4-phosphoerythronate dehydrogenase), EC
2.6.1.52 (phosphoserine transaminase), EC
1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC
2.6.99.2 (pyridoxine 5'-phosphate synthase) and EC
1.4.3.5 (with pyridoxine 5'-phosphate as substrate). 1-Deoxy-D-xylulose cannot replace 1-deoxy-D-xylulose 5-phosphate as a substrate [3].
History
EC 2.6.99.2 created 2006
Pathway
Orthology
K03474 pyridoxine 5-phosphate synthase
Genes
ECOO : ECRM13514_3391(pdxJ)
ECOH : ECRM13516_3247(pdxJ)
ECW : EcE24377A_2850(pdxJ)
EDJ : ECDH1ME8569_2491(pdxJ)
ECOI : ECOPMV1_02746(pdxJ)
REE : electrica_01200(pdxJ)
RTG : NCTC13098_01709(pdxJ)
CLAP : NCTC11466_00911(pdxJ)
KIE : NCTC12125_00155(pdxJ)
AHN : NCTC12129_03800(pdxJ)
METY : MRY16398_13330(pdxJ)
PSHI : SAMEA2665130_2356(pdxJ)
YPG : YpAngola_A3614(pdxJ)
YPI : YpsIP31758_1139(pdxJ)
SMW : SMWW4_v1c37670(pdxJ)
SFJ : SAMEA4384070_3778(pdxJ)
SOF : NCTC11214_02998(pdxJ)
PAQU : DMB82_0005930(pdxJ)
DIC : Dpoa569_000886(pdxJ)
TPTY : NCTC11468_02838(pdxJ)
PHEI : NCTC12003_01411(pdxJ)
PRJ : NCTC6933_02550(pdxJ)
LRI : NCTC12151_02421(pdxJ)
XFU : XFF4834R_chr00130(pdxJ)
XPH : XppCFBP6546_11760(XppCFBP6546P_11760)
XHD : LMG31886_00130(pdxJ)
LLZ : LYB30171_00018(pdxJ)
VAU : VANGNB10_cI2218c(pdxJ)
VPL : SA104470976_00369(pdxJ)
PAEB : NCGM1900_2005(pdxJ)
PVD : CFBP1590__1342(pdxJ)
PPRC : PFLCHA0_c10930(pdxJ)
PMUD : NCTC8068_04285(pdxJ)
PFW : PF1751_v1c10210(pdxJ)
PPUU : PputUW4_00961(pdxJ)
PGY : AWU82_18885 AWU82_29215
PTRT : HU722_0006530(pdxJ)
PTW : TUM18999_43850(pdxJ)
PTAE : NCTC10697_03536(pdxJ)
PDEN : F1C79_00055(pdxJ) F1C79_31915(pdxJ)
MSHE : MAALD49_10670(pdxJ)
PSYC : DABAL43B_0432(pdxJ)
MCAT : MC25239_01613(pdxJ)
MCUN : NCTC10297_00764(pdxJ)
SCAA : TUM17387_11340(pdxJ)
SALH : HMF8227_00519(pdxJ)
CBS : COXBURSA331_A1678(pdxJ)
LLG : 44548918_00851(pdxJ)
LJR : NCTC11533_00990(pdxJ)
LCJ : NCTC11976_02714(pdxJ)
LWA : SAMEA4504053_2226(pdxJ)
LSS : NCTC12082_00929(pdxJ)
LADL : NCTC12735_00970(pdxJ)
LANT : TUM19329_22580(pdxJ)
MISZ : MishRS11D_31440(pdxJ)
TIB : THMIRHAM_09450(pdxJ)
TSE : THMIRHAS_14990(pdxJ)
TZO : THMIRHAT_12230(pdxJ)
TFRI : Thiofri_02552(pdxJ)
TNI : TVNIR_0831(pdxJ_[H])
GAI : IMCC3135_05400(pdxJ_1) IMCC3135_11415(pdxJ_2)
THIC : TspCOW1_15890(pdxJ)
HAXI : HAALTHF_33670n(pdxJ)
ALCA : ASALC70_03825(pdxJ)
AEL : NCTC12917_03581(pdxJ)
NMM : NMBM01240149_1641(pdxJ)
NMS : NMBM01240355_0456(pdxJ)
NMQ : NMBM04240196_0454(pdxJ)
NMZ : NMBNZ0533_1802(pdxJ)
NMX : NMA510612_2293(pdxJ)
NWE : SAMEA3174300_0164(pdxJ)
NZO : SAMEA4504057_1513(pdxJ)
NCI : NCTC10296_01673(pdxJ)
NCZ : NCTC10294_01249(pdxJ)
NANI : NCTC12227_01324(pdxJ)
ECOR : SAMEA4412678_1352(pdxJ)
BMV : BMASAVP1_A2463(pdxJ)
BML : BMA10229_A2818(pdxJ)
BPM : BURPS1710b_2892(pdxJ)
BPL : BURPS1106A_2837(pdxJ)
BCJ : BCAL1008(pdxJ2) BCAL2862(pdxJ1)
BUE : BRPE67_ACDS19540(pdxJ)
PLG : NCTC10937_01123(pdxJ)
LMIR : NCTC12852_01963(pdxJ)
BUO : BRPE64_ACDS19630(pdxJ)
VTR : MYVALT_G_02870(pdxJ)
BTRM : SAMEA390648704156(pdxJ)
AXX : ERS451415_04636(pdxJ)
LIM : L103DPR2_02421(pdxJ)
LIH : L63ED372_00827(pdxJ)
JAL : BZG29_19885 BZG29_24320
JSV : CNX70_20045 CNX70_24715
JAS : FJQ89_09720(pdxJ) FJQ89_13950
JAH : JAB4_040440(pdxJ_1) JAB4_050080(pdxJ_2)
JRI : P9875_20430(pdxJ) P9875_25410
UND : UNDKW_1968(pdxJ) UNDKW_5387(pdxJ)
ACTB : RHM62_04260 RHM62_08675
URU : DSM104443_02376(pdxJ)
UPL : DSM104440_02119(pdxJ)
FPHO : SHINM1_009860(pdxJ)
ERW : ERWE_CDS_02980(pdxJ)
ERG : ERGA_CDS_02920(pdxJ)
RBS : RHODOSMS8_01271(pdxJ)
SMEL : SM2011_c01407(pdxJ)
SFD : USDA257_c44090(pdxJ)
SAME : SAMCFNEI73_Ch2368(pdxJ)
AGR : AGROH133_07263(pdxJ)
ARUI : G6M88_02725 G6M88_23635
AVV : RvVAT039_02750(pdxJ)
AVF : RvVAR031_23470(pdxJ)
REC : RHECIAT_CH0002911(pdxJ)
REL : REMIM1_CH02811(pdxJ)
REP : IE4803_CH02905(pdxJ)
REI : IE4771_CH02935(pdxJ)
RTR : RTCIAT899_CH10960(pdxJ)
RGA : RGR602_CH02423(pdxJ)
RPHA : AMC79_CH02924(pdxJ)
NEN : NCHU2750_15710(pdxJ)
LAS : CLIBASIA_01615(pdxJ)
BIO : BR141012304_11325(pdxJ)
VGO : GJW-30_1_03279(pdxJ)
BHS : BM1374165_01131(pdxJ)
BTX : BM1374166_01478(pdxJ)
BEZ : NCTC12898_00995(pdxJ)
MAQU : Maq22A_c14130(pdxJ)
MTUN : MTUNDRAET4_1399(pdxJ)
FIL : BN1229_v1_3015(pdxJ)
FIY : BN1229_v1_2901(pdxJ)
BVY : NCTC9239_01191(pdxJ)
TSV : DSM104635_02168(pdxJ)
RLI : RLO149_c032310 RLO149_c034240(pdxJ)
PHP : PhaeoP97_00330(pdxJ)
PPIC : PhaeoP14_02950(pdxJ)
LMD : METH_00755 METH_10720
LAQU : R2C4_07310 R2C4_16335
LCAE : K3721_00905 K3721_10025
SINL : DSM14862_03076(pdxJ)
SPSE : SULPSESMR1_02671(pdxJ)
RMM : ROSMUCSMR3_01332(pdxJ)
AHT : ANTHELSMS3_00069(pdxJ)
LALG : LentiSH36_02246(pdxJ)
LVS : LOKVESSMR4R_00192(pdxJ)
SBIN : SBA_ch1_03950(pdxJ)
SFLA : SPHFLASMR4Y_03042(pdxJ)
ABS : AZOBR_p1170088(pdxJ)
TMO : TMO_1593(pdxJ) TMO_c0631(pdxJ)
HPO : HMPREF4655_20202(pdxJ)
HPX : HMPREF0462_1605(pdxJ)
HCL : NCTC13205_00721(pdxJ)
HSH : NHP194022_11010(pdxJ)
HPUL : NCTC13154_01644(pdxJ)
CJV : MTVDSCj20_1244(pdxJ)
CFV : CFVI03293_0648(pdxJ)
CAMP : CFT03427_0671(pdxJ)
CLR : UPTC16701_0899(pdxJ)
CLM : UPTC16712_0929(pdxJ)
CAMR : CAQ16704_0919(pdxJ)
CHV : CHELV3228_0822(pdxJ)
CAMZ : CVIC12175_0984(pdxJ)
GBN : GEOBRER4_16290(pdxJ)
PPOR : JCM14722_01070(pdxJ)
MFB : MFUL124B02_00220 MFUL124B02_26595
SBF : JCM31447_14660(pdxJ)
SYR : SynRCC307_1553(pdxJ)
SYX : SynWH7803_1371(pdxJ)
SYH : Syncc8109_0970(pdxJ)
SYNW : SynWH8103_01041(pdxJ)
TVN : NIES2134_110810(pdxJ)
LET : O77CONTIG1_02449(pdxJ)
SYP : SYNPCC7002_A0094(pdxJ)
SYNN : NIES970_03480(pdxJ)
MVZ : myaer102_00960(pdxJ)
PAGH : NIES204_34340(pdxJ)
PRUN : PCC7821_00440(pdxJ)
NFL : COO91_04121 COO91_08786
CALN : NIES2098_65370(pdxJ)
RIV : Riv7116_4462 Riv7116_5835
NSPH : BDGGKGIB_04377(pdxJ)
AEE : IM676_02990 IM676_12785
NCN : BZZ01_17725 BZZ01_23025
CTHE : Chro_1385 Chro_4954
OBG : Verru16b_00442(pdxJ)
ABIW : Abiwalacus_16190(pdxJ)
LCRE : Pla8534_24770(pdxJ)
BTHO : Btheta7330_00511(pdxJ)
BCEL : BcellWH2_01770(pdxJ)
PCRE : NCTC12858_01833(pdxJ)
PCAG : NCTC12856_00588(pdxJ)
PSOE : CE91St14_04190(pdxJ)
COPR : Cop2CBH44_19170(pdxJ)
ACOU : A5CBH24_08480(pdxJ)
ADA : A5CPEGH6_08630(pdxJ)
SMIZ : 4412673_00397(pdxJ)
SDJ : NCTC13534_00397(pdxJ)
STHA : NCTC11429_01932(pdxJ)
PSEZ : HME7025_02193(pdxJ)
FOK : KK2020170_10500(pdxJ)
PHG : KCTC32516_00370(pdxJ)
AALG : AREALGSMS7_02452(pdxJ)
KOS : KORDIASMS9_01770(pdxJ)
KAN : IMCC3317_36030(pdxJ)
SPON : HME9304_02204(pdxJ)
CGLE : NCTC11432_01958(pdxJ)
CTAI : NCTC12078_03495(pdxJ)
CTAK : 4412677_00870(pdxJ)
CHRJ : CHRYMOREF3P_1627(pdxJ)
CJG : NCTC13459_02783(pdxJ)
CANT : NCTC13489_02837(pdxJ)
PTAN : CRYO30217_00747(pdxJ)
PROC : Ptc2401_00482(pdxJ)
» show all
Taxonomy
Reference
Authors
Garrido-Franco M.
Title
Pyridoxine 5'-phosphate synthase: de novo synthesis of vitamin B6 and beyond.
Journal
Sequence
Reference
Authors
Garrido-Franco M, Laber B, Huber R, Clausen T.
Title
Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis.
Journal
Sequence
Reference
Authors
Laber B, Maurer W, Scharf S, Stepusin K, Schmidt FS.
Title
Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein.
Journal
Sequence
Reference
Authors
Franco MG, Laber B, Huber R, Clausen T.
Title
Structural basis for the function of pyridoxine 5'-phosphate synthase.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.6.99.2
ExPASy - ENZYME nomenclature database: 2.6.99.2