KEGG   ENZYME: 2.6.99.3
Entry
EC 2.6.99.3                 Enzyme                                 
Name
O-ureido-L-serine synthase;
dcsD (gene name)
Class
Transferases;
Transferring nitrogenous groups;
Transferring other nitrogenous groups
Sysname
O-acetyl-L-serine:hydroxyurea 2-amino-2-carboxyethyltransferase
Reaction(IUBMB)
O-acetyl-L-serine + hydroxyurea = O-ureido-L-serine + acetate [RN:R10461]
Reaction(KEGG)
R10461
Substrate
O-acetyl-L-serine [CPD:C00979];
hydroxyurea [CPD:C07044]
Product
O-ureido-L-serine [CPD:C20639];
acetate [CPD:C00033]
Comment
The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species. Also catalyses EC 2.5.1.47, cysteine synthase.
History
EC 2.6.99.3 created 2013
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19725  O-ureido-L-serine/cysteine synthase
Reference
1  [PMID:20086163]
  Authors
Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
  Title
Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
  Journal
Antimicrob Agents Chemother 54:1132-9 (2010)
DOI:10.1128/AAC.01226-09
  Sequence
Reference
2  [PMID:23529730]
  Authors
Uda N, Matoba Y, Kumagai T, Oda K, Noda M, Sugiyama M
  Title
Establishment of an in vitro D-cycloserine-synthesizing system by using O-ureido-L-serine synthase and D-cycloserine synthetase found in the biosynthetic pathway.
  Journal
Antimicrob Agents Chemother 57:2603-12 (2013)
DOI:10.1128/AAC.02291-12
Other DBs
ExplorEnz - The Enzyme Database: 2.6.99.3
IUBMB Enzyme Nomenclature: 2.6.99.3
ExPASy - ENZYME nomenclature database: 2.6.99.3
BRENDA, the Enzyme Database: 2.6.99.3

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