KEGG   ENZYME: 2.7.1.143
Entry
EC 2.7.1.143                Enzyme                                 
Name
diphosphate-purine nucleoside kinase;
pyrophosphate-purine nucleoside kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
diphosphate:purine nucleoside phosphotransferase
Reaction(IUBMB)
diphosphate + a purine nucleoside = phosphate + a purine mononucleotide [RN:R03699]
Reaction(KEGG)
R03699
Substrate
diphosphate [CPD:C00013];
purine nucleoside [CPD:C15586]
Product
phosphate [CPD:C00009];
purine mononucleotide [CPD:C05325]
Comment
The enzyme from the Acholeplasma class of Mollicutes catalyses the conversion of adenosine, guanosine and inosine to AMP, GMP and IMP. ATP cannot substitute for diphosphate as a substrate.
History
EC 2.7.1.143 created 1999
Reference
1  [PMID:6330034]
  Authors
Tryon VV, Pollack D.
  Title
Purine metabolism in Acholeplasma laidlawii B: novel PPi-dependent nucleoside kinase activity.
  Journal
J Bacteriol 159:265-70 (1984)
DOI:10.1128/JB.159.1.265-270.1984
Reference
2
  Authors
Tryon, V.V., Pollack, J.D.
  Title
Distinctions in Mollicutes purine metabolism: pyrophosphate-dependent nucleoside kinase and dependence on guanylate salvage.
  Journal
Int J Systematic Bacteriol 35:497-501 (1985)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.143
IUBMB Enzyme Nomenclature: 2.7.1.143
ExPASy - ENZYME nomenclature database: 2.7.1.143
BRENDA, the Enzyme Database: 2.7.1.143
CAS: 70356-41-1

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Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (17)   
   PDBSTR (17)   
3D Structure (5)   
   PDB (5)   
All databases (28)   

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