KEGG   ENZYME: 2.7.1.168
Entry
EC 2.7.1.168                Enzyme                                 
Name
D-glycero-alpha-D-manno-heptose-7-phosphate kinase;
D-alpha-D-heptose-7-phosphate kinase;
hdda (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:D-glycero-alpha-D-manno-heptose 7-phosphate 1-phosphotransferase
Reaction(IUBMB)
D-glycero-alpha-D-manno-heptose 7-phosphate + ATP = D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + ADP [RN:R09770]
Reaction(KEGG)
R09770
Substrate
D-glycero-alpha-D-manno-heptose 7-phosphate [CPD:C19878];
ATP [CPD:C00002]
Product
D-glycero-alpha-D-manno-heptose 1,7-bisphosphate [CPD:C19879];
ADP [CPD:C00008]
Comment
The enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein in Gram-positive bacteria. The enzyme is specific for the alpha-anomer.
History
EC 2.7.1.168 created 2010
Pathway
ec00540  Lipopolysaccharide biosynthesis
ec01100  Metabolic pathways
Orthology
K07031  D-glycero-alpha-D-manno-heptose-7-phosphate kinase
Genes
YPB: YPTS_1055
YPQ: DJ40_1348
YPU: BZ21_254
YPR: BZ20_1035
YPC: BZ23_530
YMO: HRD69_10995
YAS: N0H69_17365
PLU: plu4822(wblW)
PLUM: A4R40_23985
LSOL: GOY17_03450
LHX: LYSHEL_08800
LCAS: LYSCAS_08800
THES: FHQ07_06205
TBV: H9L17_06865
VAF: D1115_23010
VSR: Vspart_00200
VZI: G5S32_14885
VJP: NP165_18370
VRU: RND59_05090
PGB: H744_1c0473 H744_2c2398
PGH: FH974_09840
PPB: PPUBIRD1_1475
PEN: PSEEN2467
PALL: UYA_23045
PBZ: GN234_10450
PKH: JLK41_16270
PMUY: KSS95_17170
PORY: EJA05_20065
PWZ: J7655_08610
PSIH: LOY51_19410
PASI: LG197_25600
PAGR: E2H98_17350
SBB: Sbal175_1477
PSHO: KQ246_01935
AMAG: I533_13340
CEB: B0D95_15720
CENO: CEAn_00649
ASIP: AQUSIP_17830(hddA)
METL: U737_03390
MMOB: F6R98_01280 F6R98_19120
MEIN: methR_P2381
MESL: KKZ03_15230
HTR: EPV75_08915
TVI: Thivi_4045
HCH: HCH_06166
HAHE: ENC22_26595
HAHH: O5O45_29400
TOL: TOL_2206
TOR: R615_06625
ENW: MJO57_17205
CHRM: FYK34_20160
REU: Reut_A0720
CUP: BKK80_17040
CUU: BKK79_15315
BMA: BMA2296(hddA)
BMV: BMASAVP1_A0532(hddA)
BML: BMA10229_A1068(hddA)
BMN: BMA10247_2174(hddA)
BMAL: DM55_1488
BMAE: DM78_2666
BMAQ: DM76_1466
BMAI: DM57_1071
BMAF: DM51_1937
BMAZ: BM44_1067
BMAB: BM45_2462
BPS: BPSL2796(wcbL)
BPM: BURPS1710b_3292(wcbL)
BPL: BURPS1106A_3278
BPD: BURPS668_3243
BPR: GBP346_A3421
BPSE: BDL_2649
BPSM: BBQ_513
BPSU: BBN_641
BPSD: BBX_1047
BPZ: BP1026B_I0514(wcbL)
BPQ: BPC006_I3326
BPK: BBK_2134
BPSH: DR55_1722
BPSA: BBU_2766
BPSO: X996_1362
BUT: X994_3360
BTD: BTI_920
BTHA: DR62_529
BCEW: DM40_4219
BLAT: WK25_23460
BSTL: BBJ41_08340
BARI: NLX30_31965
BAEN: L3V59_19725
BPLA: bpln_1g18350
BUZ: AYM40_03120 AYM40_03400
BCAI: K788_0007827
PHS: C2L64_13965
PMEG: FNZ07_18185
PACS: FAZ98_02525
PBON: QS306_10760
PPAL: AOC06_01770
PCOS: C2747_01695
PYT: PKF023_03470
PAPI: SG18_07840
TVL: FAZ95_17375
TCAR: U0034_03680
RSB: RS694_17775
RDP: RD2015_4052
ATER: MW290_21700 MW290_27360
HSE: Hsero_4413
HSZ: ACP92_22040
HFR: G5S34_23500
MASS: CR152_19255
AON: DEH84_17460
NET: Neut_0157
MEH: M301_2248
MBAT: BN1208_0905 BN1208_0916
MEU: ACJ67_08030
ARES: IWH25_01535
NIV: JY500_12300
REN: EF513_03810
MOH: IHQ72_18970
SFD: USDA257_c10760
RLT: Rleg2_5597
RLB: RLEG3_01580
RHN: AMJ98_PB00039
RPHA: AMC79_PA00039
RHX: AMK02_PB00038
REZ: AMJ99_PA00039
RJG: CCGE525_26860
RAD: CO657_35040
RII: FFM53_035125
RHID: FFM81_022900
RLN: J0663_28370
RBAN: J2J98_27900
RBW: RLCC275e_32010
BJA: blr5970(blr5970)
BRC: BCCGELA001_23760 BCCGELA001_25425
BOT: CIT37_24415
BRQ: CIT40_21825
BSYM: CIT39_21115
BDG: LPJ38_30125 LPJ38_31860
BQB: J4P68_0034315
BCOU: IC761_11755
BRAZ: LRP30_27525
MRD: Mrad2831_1227
MOR: MOC_1454
MPHY: MCBMB27_00831
METX: A3862_24530
METS: DK389_08185
METI: DK427_00615
MLG: CWB41_06520
DOY: JI749_13905
MECQ: MSC49_37250
MLUT: JET14_03495
AUB: LXB15_15190
CAK: Caul_4922
CSE: Cseg_1876 Cseg_1877
CMB: CSW64_13090 CSW64_13095
CFH: C1707_06540
CAUL: KCG34_18330
BVC: CEP68_07765
BREV: E7T10_02320
BND: KWG56_04310 KWG56_04315
AEX: Astex_2282
JAN: Jann_4245
KVL: KVU_0341(lmbP)
KVU: EIO_0807
RSU: NHU_00146
RHM: B5V46_02155
NRE: BES08_12530
SSAN: NX02_24820
SCH: Sphch_2708
AZL: AZL_f00470
ALI: AZOLI_p60015
ABQ: ABAZ39_33030
ATI: AL072_31755
AZM: DM194_26760
AZZ: DEW08_29825
NAO: Y958_28035
NCB: C0V82_26600
MGY: MGMSRv2__4176
MAGX: XM1_1802
MAGN: WV31_16785
FER: FNB15_03135 FNB15_03245
MAG: amb1073
MAGQ: MGMAQ_1158
MGM: Mmc1_0617
APB: SAR116_0985
HPUL: NCTC13154_01559
CJE: Cj1425c(hddA)
CJB: BN148_1425c(hddA)
CJJ: CJJ81176_1424
CJN: ICDCCJ07001_1356
CJS: CJS3_1518
CJEJ: N564_01422
CJEU: N565_01462
CJEN: N755_01459
CJEI: N135_01515
CJER: H730_08145
CJY: QZ67_01564(hddA)
CJQ: UC78_1366(hddA)
CJW: PJ18_07300
CJR: CJE1610
CJD: JJD26997_1759
CJZ: M635_02850
CJX: BN867_14020
CLR: UPTC16701_0316
CLM: UPTC16712_0314
CLN: UPTC3659_0326
CCF: YSQ_01735
CIS: CINS_0292
CAMR: CAQ16704_0315
CSM: CSUB8521_0327
CHV: CHELV3228_0216
CCUN: CCUN_1153
CLX: CLAN_0156
CHW: A2J15_004900
CAMZ: CVIC12175_0184
COJ: CORN_0313
CUX: CUP3940_1433
CARM: CARM_0281
CNV: CNZW441b_0360
CVU: CVULP_1507
ANT: Arnit_2925
ALK: ALEK_0995
AMYT: AMYT_0706
HMR: Hipma_1693
GLO: Glov_0793
DMA: DMR_p1_00290
DAS: Daes_0075
DPI: BN4_12080
PPRF: DPRO_PA0008(hddA)
LIP: LIA008(mvaK1) LIC011(mvaK1)
LIR: LAW_10008 LAW_30012
DOL: Dole_1710
DAL: Dalk_0045 Dalk_1697
DAT: HRM2_28150
DTO: TOL2_C22230
DOV: DSCO28_03340 DSCO28_69630
DWD: DSCW_17180
DALK: DSCA_16630
DML: Dmul_12370
DLI: dnl_13350
DTI: Desti_0156 Desti_4186
DMP: FAK_14240
TCM: HL41_06285
APAU: AMPC_02950
SCL: sce0565 sce3746
SCU: SCE1572_03850 SCE1572_22545
CCRO: CMC5_014780 CMC5_049810
PAUU: E8A73_015170 E8A73_034250
MRM: A7982_01767 A7982_09688
BBA: Bd1027(lmbP)
BBAT: Bdt_0972(lmbP)
BBW: BDW_03545
BBAC: EP01_15225
BDQ: CIK05_03850
BDC: DOE51_04845
BDZ: DOM22_15170 DOM22_19045
BDK: HW988_14160 HW988_18085
BREY: MNR06_07585
BEX: A11Q_821
BMX: BMS_0715
HAX: BALOs_0673(hddA)
BSTO: C0V70_03945
PSTI: SOO65_05750
SBF: JCM31447_25540
PIJ: QEJ31_04455
PPSC: EHS13_28200
PRZ: GZH47_12305
PALR: HGI30_17915
ASOC: CB4_00632(hddA)
AFX: JZ786_00205
ACUR: JZ785_20290
LLK: LLKF_2314
LLX: NCDO2118_2176
LLM: llmg_2347
LLR: llh_12025
LLN: LLNZ_12135
LLW: kw2_2126
EFAU: EFAU085_01996
CAC: CA_C3055
CAE: SMB_G3091(mvk)
CAY: CEA_G3061
CFER: D4Z93_01730
CRW: CROST_039030(hddA)
CFB: CLFE_008790(hddA)
CAUN: CLAUR_036230(hddA)
CNN: CNEO_3852
CGEL: psyc5s11_31730
HHJ: NQ487_27315
RUK: A4V00_01665
RHER: EHE19_007360
RPAY: P0092_03715
FPA: FPR_02560
AMUR: ADH66_07410
AGAT: RWV98_16160
SGY: Sgly_1518
DMI: Desmer_4162
DEC: DCF50_p1138
HMO: HM1_1146
BPRM: CL3_13500
BPRS: CK3_00760
RHO: RHOM_00840
BMAS: LK422_09255
BLUI: Blut17040_12350
LACY: A4V08_12910
CHYL: CE91St63_29560
CSH: Closa_3476 Closa_3798
CSO: CLS_35520
LXA: OW255_03130
LUA: D4A81_02550
LGG: QJR73_01610 QJR73_01655
ACEL: acsn021_05310
RTO: RTO_07330
CBOL: CGC65_03665
CASP: NQ535_04235
STOM: QU660_01640
AMIJ: EQM06_00985
GFE: Gferi_13890
SRI: SELR_05810
PUF: UFO1_1095
AOC: Aocu_04590(hddA)
EYY: EGYY_07210
RTS: CE91St31_13170(hddA)
MTU: Rv0115(hddA)
MTV: RVBD_0115
MTC: MT0123
MRA: MRA_0121(hddA)
MTF: TBFG_10116
MTB: TBMG_00116
MTK: TBSG_00116
MTZ: TBXG_000116
MTG: MRGA327_00755
MTI: MRGA423_00745
MTE: CCDC5079_0100
MTUR: CFBS_0124(hddA)
MTL: CCDC5180_0100
MTO: MTCTRI2_0118(hddA)
MTD: UDA_0115(hddA)
MTN: ERDMAN_0133(hddA)
MTJ: J112_00635
MTUB: MT7199_0117
MTUC: J113_00815
MTUE: J114_00635
MTUH: I917_00875
MTUL: TBHG_00115
MTUT: HKBT1_0124(hddA)
MTUU: HKBT2_0124(hddA)
MTQ: HKBS1_0124(hddA)
MBO: BQ2027_MB0119(hdda)
MBB: BCG_0149
MBT: JTY_0119
MBM: BCGMEX_0119
MBK: K60_001280
MBX: BCGT_3912
MMIC: RN08_0133
MCE: MCAN_01181(hddA)
MCQ: BN44_10139
MCV: BN43_10134
MCX: BN42_10154
MCZ: BN45_10131
MPA: MAP_0935
MAO: MAP4_2925
MAVI: RC58_14520
MAVU: RE97_14545
MAV: MAV_1118
MIT: OCO_09890
MIA: OCU_09910
MID: MIP_01627
MYO: OEM_10070
MCHI: AN480_06105
MIR: OCQ_10000
MMAL: CKJ54_04905
MMAN: MMAN_53260
MMM: W7S_04930
MSHG: MSG_04047
MFJ: MFLOJ_46240
MSTO: MSTO_50140
MSIM: MSIM_36030
MSEO: MSEO_28410
MMAM: K3U93_19695
MHIB: MHIB_05030
SRN: A4G23_00465(hddA)
SLS: SLINC_0247
SFB: CP974_02425
SPEU: CGZ69_25265
SOV: QZH56_04565
DNI: HX89_08010
DAY: FV141_07215
DERM: H7F30_10195
LMOI: VV02_14415
ALX: LVQ62_11820
BEI: GCM100_18490
CFL: Cfla_3600
JTE: ASJ30_08440
JLI: EXU32_05930
JME: EEW87_006825
JAY: H7A72_08590
JCR: O9K63_05260
PHW: G7075_07290
PACD: EGX94_01660
ARUB: J5A65_04980
NANO: G5V58_20170
ASEZ: H9L21_09055
ADB: NP095_09275
AWN: NQV15_07320
AMQ: AMETH_0529
ATHM: L1857_05240
MCRA: ID554_07380
PFLA: Pflav_030370
PSUU: Psuf_092480
DROS: Drose_17380
DAUR: Daura_25140
ABAM: B1s21122_06220
JCY: M6B22_15975
BSOL: FSW04_03040
CWO: Cwoe_5465
PARN: NBH00_10490
TALU: JDY09_01790
AQZ: KSP35_05855
IAM: HC251_07750
SYN: slr0862(lmbP)
SYZ: MYO_112400(lmbP)
SYY: SYNGTS_1229(lmbP)
SYT: SYNGTI_1229(lmbP)
SYS: SYNPCCN_1228(lmbP)
SYQ: SYNPCCP_1228(lmbP)
SYJ: D082_22800(lmbP)
SYO: C7I86_06370
PMI: PMT9312_1336
PMH: P9215_14351
PRC: EW14_1456
WNA: KA717_12405
ACAM: HRE53_32790
KOV: K9N68_31470
GEN: GM3709_2003
GEE: GM3708_2935
CAN: Cyan10605_0572
MAR: MAE_55670
MPK: VL20_390
MIQ: B5D77_10625
MVZ: myaer102_27910
CYU: UCYN_11570
CYT: cce_0966(lmbP)
CWA: CwatDRAFT_2260
CYP: PCC8801_1635
CYH: Cyan8802_1662
NOE: CLI64_01830
CRK: L3I90_05440
CEO: ETSB_0016(lmbP)
CER: RGRSB_1052(lmbP)
CEEC: P3F56_09995
DET: DET0206
DEB: DehaBAV1_0147
DMD: dcmb_209
DMY: X793_00955
DUC: UCH007_02360
RRS: RoseRS_0952 RoseRS_1374 RoseRS_4217
RCA: Rcas_0447 Rcas_3581 Rcas_3592
CAU: Caur_3438 Caur_3750
CHL: Chy400_3700 Chy400_4051
CAG: Cagg_0374 Cagg_0788
HAU: Haur_3668
ATM: ANT_19990
CAP: CLDAP_36340
PBF: CFX0092_A1520
KBS: EPA93_37990
KBB: ccbrp13_38630
THUG: KNN16_04655
TTR: Tter_0153 Tter_2647
TRA: Trad_1639
MSV: Mesil_0236
MHD: Marky_1653
CCZ: CCALI_00208 CCALI_02129
CCOT: CCAX7_47070
SNG: SNE_A16710
OTE: Oter_3977
VBH: CMV30_09125
MTAR: DF168_01773(hddA)
ROO: G5S37_00860
VEG: SAMN05444156_2642
AAGG: ETAA8_22160(hddA)
ACAF: CA12_42420(hddA)
TPOL: Mal48_40710(hddA)
GES: VT84_07095(hddA_1) VT84_15600(hddA_2)
GOG: C1280_05615 C1280_17645
GMS: SOIL9_33210 SOIL9_49840
FTJ: FTUN_2609 FTUN_5819
ULI: ETAA1_15250(hddA)
KST: KSMBR1_2293(mvk)
BPIT: BPIT_11870 BPIT_20170
HBS: IPV69_10385
VAI: BU251_02245
TPI: TREPR_2396
TSK: HRI97_06125
TAZ: TREAZ_0677
ABA: Acid345_2431
ACA: ACP_0827
ABAS: ACPOL_2477
ADIN: H7849_01375
SUS: Acid_0418
PFER: IRI77_13950 IRI77_21585
CTM: Cabther_A1094
CVL: J8C06_06790
CHLO: J8C02_05310
ABAC: LuPra_03128 LuPra_04981
LUB: TBR22_A22050
GEX: GETHOR_18940
MSIL: METEAL_02470
MSEA: METESE_02530
FVA: FV113G1_09550
FUL: C4N20_04110
HABY: HLVA_19760(hddA)
AMO: Anamo_1882
GAU: GAU_0471
GPH: GEMMAAP_03085
GGR: HKW67_12705
GBA: J421_2375
BTH: BT_0474
BTHO: Btheta7330_02888(hddA_2)
BFG: BF638R_1442
BOA: Bovatus_04910(hddA_2)
PARC: CI960_06785
PGOL: K6V26_21085
PCOU: L6468_04005
PCOI: LK433_04715
SBAO: L6469_11235 L6469_11265 L6469_11305
PCLR: PC1C4_23790
ALD: GFH31_01600 GFH31_09970
AIT: AI2BBH_01740
AIU: NQ491_03835 NQ491_10960
CPI: Cpin_3115
CHIH: GWR21_07425
COY: HF329_02890
CFIL: MYF79_22175
CHF: KTO58_06625
CSAC: SIO70_23830
NKO: Niako_2547
NSO: NIASO_09030
NIA: A8C56_12850
NYN: U0035_05260
FLA: SY85_01490
ARK: D6B99_15390
ARAC: E0W69_018550
FLN: FLA_6276
PSEG: D3H65_10785
PGIN: FRZ67_05010
PGO: FSB84_23220
FLS: GLV81_14335
FEI: K9M53_08240
FLP: LK994_12835
SEDT: TEGAF0_25510
THEO: IMW88_11165
MDJ: LLH06_15000
MAQA: LAG90_13975
CLIT: OQ292_00180
CHRW: KA713_13925
WIN: WPG_0814
KAN: IMCC3317_07720(hddA)
OHO: Oweho_0133
PAA: Paes_1742
TFE: JYK00_02910
MPZ: Marpi_1232
MARN: LN42_06525
NDE: NIDE2328 NIDE3425(hddA)
NALL: PP769_09060 PP769_12640
NNEO: PQG83_03485 PQG83_20295
LFI: LFML04_1771
NLI: G3M70_02430
NVA: G3M78_06055 G3M78_07650
MOX: DAMO_0938 DAMO_2477
MIB: UY43_C0001G0762
NBN: HYY55_04600
FSH: Q2T83_17375
MPI: Mpet_1390
MANQ: L1994_11750
TAC: Ta0344 Ta1304
TVO: TVG0491501(TVG0491501) TVG0927911(TVG0927911)
PTO: PTO1352
FAC: FACI_IFERC01G0294 FACI_IFERC01G1807
FAI: FAD_0776 FAD_1211
CDIV: CPM_0438 CPM_1015
TAR: TALC_00062
MAX: MMALV_00710
MER: MMINT_13630
MEAR: Mpt1_c11480(mvk2) Mpt1_c11600(galK)
MEUZ: KRP56_00625 KRP56_00640
MARC: AR505_1771
NKR: NKOR_00435
NID: NPIRD3C_0048
NUE: C5F50_00845
NBV: T478_0176
CCAI: NAS2_1392
MARH: Mia14_0639
LOKI: Lokiarch_02870(hddA)
AGW: QT03_C0001G0606
 » show all
Reference
1  [PMID:11279237]
  Authors
Kneidinger B, Graninger M, Puchberger M, Kosma P, Messner P
  Title
Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose.
  Journal
J Biol Chem 276:20935-44 (2001)
DOI:10.1074/jbc.M100378200
  Sequence
[ag:AAK27850]
Reference
2  [PMID:12101286]
  Authors
Valvano MA, Messner P, Kosma P
  Title
Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides.
  Journal
Microbiology 148:1979-89 (2002)
DOI:10.1099/00221287-148-7-1979
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.168
IUBMB Enzyme Nomenclature: 2.7.1.168
ExPASy - ENZYME nomenclature database: 2.7.1.168
BRENDA, the Enzyme Database: 2.7.1.168

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (32695)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (651)   
   KEGG MGENES (23517)   
   RefGene (8526)   
Protein sequence (277)   
   UniProt (271)   
   SWISS-PROT (3)   
   RefSeq(pep) (3)   
DNA sequence (129)   
   RefSeq(nuc) (3)   
   GenBank (63)   
   EMBL (63)   
Protein domain (7)   
   InterPro (7)   
All databases (33119)   

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