KEGG   ENZYME: 2.7.1.176
Entry
EC 2.7.1.176                Enzyme                                 
Name
UDP-N-acetylglucosamine kinase;
UNAG kinase;
zeta toxin;
toxin PezT;
ATP:UDP-N-acetyl-D-glucosamine 3'-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:UDP-N-acetyl-alpha-D-glucosamine 3'-phosphotransferase
Reaction(IUBMB)
ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate [RN:R09946]
Reaction(KEGG)
R09946
Substrate
ATP [CPD:C00002];
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043]
Product
ADP [CPD:C00008];
UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate [CPD:C20245]
Comment
Toxic component of a toxin-antitoxin (TA) module. The phosphorylation of UDP-N-acetyl-D-glucosamine results in the inhibition of EC 2.5.1.7, UDP-N-acetylglucosamine 1-carboxyvinyltransferase, the first committed step in cell wall synthesis, which is then blocked. The activity of this enzyme is inhibited when the enzyme binds to the cognate epsilon antitoxin.
History
EC 2.7.1.176 created 2012
Orthology
K16214  UDP-N-acetylglucosamine kinase
Genes
EOIECO111_4845
EOJECO26_5138
EOHECO103_4771
ECOOECRM13514_5156
ECOHECRM13516_4893
ESLO3K_23750
ESOO3O_01595
ESMO3M_23670
ECKEC55989_4511
ECWEcE24377A_4571
ECOAAPECO78_00915
ECXEcHS_A4262
ECYECSE_4312
ECRECIAI1_4248
EKOEKO11_4299
EKFKO11_02260
ELWECW_m4385
ELLWFL_21320
ECOLLY180_21120
EFEEFER_4114
PSGCG163CM_19690
HPAAE5Q53_01120
MPEGHV560_06980
ADPNCTC12871_01572(pezT)
GSSNYR30_05600
PHOMKJF94_19025
NCZNCTC10294_00446
NWDH3L96_04520
NMUSH7A79_1988
NDULVJ88_11905
CHACHAB381_0158
CSPFCSF_1644
SDPNCTC12225_00482(pezT)
LPKLACPI_2325
SPNSP_1051
SPDSPD_0931
SPRspr0952
SPWSPCG_1030 SPCG_1295
SJJSPJ_0988
SNVSPNINV200_09690
SPXSPG_1259
SNESPN23F09710 SPN23F12620
SPVSPH_1263
SNMSP70585_1129
SPPSPP_1054 SPP_1189
SPNGHMPREF1038_01132(pezT)
SNBSP670_1128 SP670_1142
SNXSPNOXC09500
SNUSPNA45_01349
SPNESPN034156_00360
SPNUSPN034183_09480
SPNMSPN994038_09370
SPNOSPN994039_09380
SANgbs1343
STUSTH8232_0686
SSBSSUBM407_0967 SSUBM407_p004
SSUSSU05_0936
SSVSSU98_0943
SSSSSUSC84_0841
SSUSNJAUSS_0601
SSKSSUD12_1295
SSQSSUD9_1039
SUISSUJS14_0613
SUOSSU12_0865
SEZOSeseC_01875
SEQUQ426_01885
SMBsmi_1101
STBSGPB_1117
SCFSpaf_1102
SIUSII_0665
SANCSANR_1175
SANSDK43_04825
SOII872_04360
SIGN596_03355
STRNSNAG_0768(pezT)
SSOBDK181_06690
SEQIA6J79_10415 A6J79_11240
SGWD7D53_04515
SFERNCTC12278_00084(pezT)
SCAINCTC12191_01630(pezT)
SPOCNCTC10925_00664(pezT)
SPABKQ224_00385 KQ224_10060
SLATJ4854_01895
SURNNCTC13766_01149(pezT)
SACOSAME_01424(pezT)
EFLEF62_0807 EF62_0873
EFDEFD32_0431 EFD32_pA0010
EFSEFS1_0364 EFS1_0455
EFNDENG_00529
ENEENT_03620
EFAUEFAU085_p3010
EDULIU_03085 LIU_14570
EGVEGCR1_18660
EAVEH197_00415
ESGEsVE80_p1-00710 EsVE80_p1-00770
ERAFJ9537_20550
EDSPML78_13410
VACE4Z98_09650
JARG7057_06460
VNKVEIT17_05210
VRGOKW85_02820
SELOAXE86_10640
SDIAQU667_10975
ELEElen_0420
EGDGS424_002425
GPAGPA_16910
AEQAEQU_0417
AHATADCFC_19710
GVGHMPREF0421_21171
GVHHMPREF9231_0367
TSUTresu_0877
FUSHMPREF0409_01179
FNEFSDG_00044 FSDG_01485
FHWRN87_10340 RN87_11715
FPDCTM68_00280
FNFBSQ88_04885
FPEIC4N17_04535
FPOLERS445057_00777(pezT) ERS445057_01725
 » show all
Reference
1  [PMID:17488720]
  Authors
Khoo SK, Loll B, Chan WT, Shoeman RL, Ngoo L, Yeo CC, Meinhart A
  Title
Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae.
  Journal
J Biol Chem 282:19606-18 (2007)
DOI:10.1074/jbc.M701703200
  Sequence
[spn:SP_1051]
Reference
2  [PMID:21445328]
  Authors
Mutschler H, Gebhardt M, Shoeman RL, Meinhart A
  Title
A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis.
  Journal
PLoS Biol 9:e1001033 (2011)
DOI:10.1371/journal.pbio.1001033
  Sequence
[spn:SP_1051]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.176
IUBMB Enzyme Nomenclature: 2.7.1.176
ExPASy - ENZYME nomenclature database: 2.7.1.176
BRENDA, the Enzyme Database: 2.7.1.176

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