Entry Name 2-dehydro-3-deoxyglucono/galactono-kinase;
Class Transferases;BRITE hierarchy
Sysname ATP:2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase
Reaction(IUBMB) (1) ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate [RN:
R01541 ];
(2) ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-6-phospho-D-galactonate [RN:
R03387 ]
Reaction(KEGG) Substrate ATP [CPD:
C00002 ];
2-dehydro-3-deoxy-D-gluconate [CPD:
C00204 ];
2-dehydro-3-deoxy-D-galactonate [CPD:
C01216 ]
Product ADP [CPD:
C00008 ];
2-dehydro-3-deoxy-6-phospho-D-gluconate [CPD:
C04442 ];
2-dehydro-3-deoxy-6-phospho-D-galactonate [CPD:
C01286 ]
Comment The enzyme from the archaeon Sulfolobus solfataricus is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. It phosphorylates 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate with similar catalytic efficiency. cf. EC
2.7.1.45 , 2-dehydro-3-deoxygluconokinase and EC
2.7.1.58 , 2-dehydro-3-deoxygalactonokinase.
History EC 2.7.1.178 created 2013
Pathway Orthology K18126 2-dehydro-3-deoxygluconokinase / 2-dehydro-3-deoxygalactonokinase
Genes » show all Taxonomy Reference Authors Lamble HJ, Theodossis A, Milburn CC, Taylor GL, Bull SD, Hough DW, Danson MJ
Title Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon Sulfolobus solfataricus.
Journal Sequence Reference Authors Potter JA, Kerou M, Lamble HJ, Bull SD, Hough DW, Danson MJ, Taylor GL
Title The structure of Sulfolobus solfataricus 2-keto-3-deoxygluconate kinase.
Journal Sequence Reference Authors Kim S, Lee SB
Title Characterization of Sulfolobus solfataricus 2-keto-3-deoxy-D-gluconate kinase in the modified Entner-Doudoroff pathway.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 2.7.1.178
