KEGG ENZYME: 2.7.1.185

ENZYME: 2.7.1.185

Entry

EC 2.7.1.185                Enzyme

Name

mevalonate 3-kinase;
ATP:(R)-MVA 3-phosphotransferase

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:(R)-mevalonate 3-phosphotransferase

Reaction(IUBMB)

ATP + (R)-mevalonate = ADP + (R)-3-phosphomevalonate [RN:R10779]

Reaction(KEGG)

R10779

Substrate

ATP [CPD:C00002];
(R)-mevalonate [CPD:C00418]

Product

ADP [CPD:C00008];
(R)-3-phosphomevalonate [CPD:C20847]

Comment

Mevalonate 3-kinase and mevalonate-3-phosphate-5-kinase (EC 2.7.1.186) act sequentially in an alternate mevalonate pathway in the archaeon Thermoplasma acidophilum. Mevalonate 3-kinase is different from mevalonate kinase, EC 2.7.1.36, which transfers phosphate to position 5 of (R)-mevalonate and is part of the classical mevalonate pathway in eukaryotes and archaea.

History

EC 2.7.1.185 created 2014

Pathway

ec00900

Terpenoid backbone biosynthesis

ec01100

Metabolic pathways

Orthology

K18689

mevalonate-3-kinase

Genes

TAC: