KEGG ENZYME: 2.7.1.186

ENZYME: 2.7.1.186

Entry

EC 2.7.1.186                Enzyme

Name

mevalonate-3-phosphate 5-kinase

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:(R)-3-phosphomevalonate 5-phosphotransferase

Reaction(IUBMB)

ATP + (R)-3-phosphomevalonate = ADP + (R)-3,5-bisphosphomevalonate [RN:R10780]

Reaction(KEGG)

R10780

Substrate

ATP [CPD:C00002];
(R)-3-phosphomevalonate [CPD:C20847]

Product

ADP [CPD:C00008];
(R)-3,5-bisphosphomevalonate [CPD:C20848]

Comment

Mevalonate 3-kinase (EC 2.7.1.185) and mevalonate-3-phosphate-5-kinase act sequentially in an alternate mevalonate pathway in the archaeon Thermoplasma acidophilum.

History

EC 2.7.1.186 created 2014

Pathway

ec00900

Terpenoid backbone biosynthesis

ec01100

Metabolic pathways

Orthology

K18690

mevalonate-3-phosphate-5-kinase

Genes

TAC:

Ta0762

TVO:	TVG0885910(TVG0885910)

PTO:

PTO0479

FAC:	FACI_IFERC01G0924

FAI:	FAD_1810(pgk2)

CDIV:

CPM_0343

MARH:

Mia14_0536

MIY:	Micr_00573(pgk2_2)

Reference

1 [PMID:24914732]

Authors

Vinokur JM, Korman TP, Cao Z, Bowie JU

Title

Evidence of a novel mevalonate pathway in archaea.

Journal

Biochemistry 53:4161-8 (2014)
DOI:10.1021/bi500566q

Sequence

[tac:Ta0762]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.186

IUBMB Enzyme Nomenclature:

2.7.1.186

ExPASy - ENZYME nomenclature database:

2.7.1.186

BRENDA, the Enzyme Database:

2.7.1.186

DBGET integrated database retrieval system