KEGG ENZYME: 2.7.1.187

ENZYME: 2.7.1.187

Entry

EC 2.7.1.187                Enzyme

Name

acarbose 7IV-phosphotransferase;
acarbose 7-kinase;
AcbK

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:acarbose 7IV-phosphotransferase

Reaction(IUBMB)

ATP + acarbose = ADP + acarbose 7IV-phosphate [RN:R11184]

Reaction(KEGG)

R11184

Substrate

ATP [CPD:C00002];
acarbose [CPD:C06802]

Product

ADP [CPD:C00008];
acarbose 7IV-phosphate [CPD:C21156]

Comment

The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is specific for acarbose.

History

EC 2.7.1.187 created 2015

Pathway

ec00525

Acarbose and validamycin biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K19978

acarbose 7IV-phosphotransferase

Genes

MSX:	AU14_17890

MALL:

PBN92_19415

MSHE:

MAALD49_38210

MANP:

EHN06_15445

THAT:

H3N35_23215

TVD:	SG34_025375

PAEW:

KIH87_05050

AGZ:	M0C34_15270

CJA:

CJA_3262

HCH:

HCH_06560

HAHE:

ENC22_28710

HAHH:

O5O45_27820

RFO:	REIFOR_01851

CKS:	H9L41_13925

JAZ:	YQ44_16480

JAL:	BZG29_11390

JSV:	CNX70_11820

JAS:	FJQ89_00455

JLV:	G3257_11880

JAH:	JAB4_024470(acbK)

JRI:	P9875_12160

MVAR:

MasN3_19470

NIV:	JY500_14630

JAN:

Jann_1951

SUR:	STAUR_1373(gacK)

MBD:	MEBOL_002883

NMK:	CHR53_26640

MJO:	FOF60_11795

MSUT:

LC048_10325

PSTE:

PSTEL_21445

CCHL:

FPL14_14950

CBEI:

LF65_05135

PROQ:

P6M73_15035

LBX:

lbkm_3346

HOR:	Hore_09710

TSG:	HLK68_06310

TBK:	HF295_05705

SMA:	SAVERM_1511

SANL:

KZO11_02960

SCB:	SCAB_20401

SHY:

SHJG_7630

SHO:	SHJGH_7391

SFA:

Sfla_0297

SVE:

SVEN_7113

SDV:	BN159_1685

STRP:

F750_6718

SCI:	B446_30730

SGU:	SGLAU_01020(gacK)

STRE:

GZL_01972

SCW:	TU94_03345

SLC:	SL103_23555

SXI:	SXIM_46650

STRC:

AA958_14090

SPRI:

SPRI_1871

SCX:	AS200_09110

SRW:	TUE45_07278(kdgK_4)

SLE:	sle_62240(sle_62240)

SRN:	A4G23_05299(kdgK_4)

SGS:	AVL59_15010

SGM:	GCM10017557_11810

SCAD:

DN051_08635

SPHW:

NFX46_12550

SLS:	SLINC_7169

SNR:	SNOUR_08805

SALU:

DC74_6799

SALL:

SAZ_35315

SPLU:

LK06_028515

SNW:	BBN63_04345

SSIA:

A7J05_03525

SPUN:

BFF78_06550

SLAU:

SLA_7384

SNZ:	DC008_29530

SRJ:

SRO_6633

SLK:	SLUN_34265

SDX:	C4B68_04950

SCYA:

EJ357_02025

SAST:

CD934_07730

SNQ:	CP978_28840

STIR:

DDW44_27335

SGZ:	C0216_15315

SNK:	CP967_21885

SHAW:

CEB94_30720

SSPO:

DDQ41_28600 DDQ41_30790

SVR:	CP971_12025

SPAD:

DVK44_30925

SAQU:

EJC51_30905

SGF:	HEP81_06976

SSEO:

D0Z67_24690

SPHV:

F9278_37950

SFUG:

CNQ36_29320

SPAC:

B1H29_04410

SCHA:

CP983_06555

SGX:	H4W23_04800

SCOE:

CP976_32185

SPLA:

CP981_32500

SBRO:

GQF42_37495

STUI:

GCM10017668_53800(rbsK)

SATA:

C5746_04060

SCHF:

IPT68_31575

SHUN:

DWB77_06929(acbK)

SHAR:

HUT13_23360

SCYG:

S1361_33170(ydjH3)

SFEU:

IM697_28610

SLIA:

HA039_04205

SDW:	K7C20_31055

SAUH:

SU9_029475

SFB:	CP974_28220

SPEU:

CGZ69_28305

SROI:

IAG44_06300

SGJ:	IAG43_01740

SANU:

K7396_06165

SACT:

DMT42_32350

SINE:

KI385_36860

SDEC:

L3078_35440

SDUR:

M4V62_03095

SNIG:

HEK616_45520(kdgK)

SCAE:

IHE65_10030

SSPN:

LXH13_33225

SCIR:

STRCI_006855

SDRZ:

NEH16_01570

STUD:

STRTU_001011

SENG:

OJ254_27340

SYUN:

MOV08_08700

SARG:

HKX69_04635

SJN:	RI060_10250

SKG:	KJK29_08355

SCOA:

QU709_04815

SLAI:

P8A22_01915

SCHG:

NRO40_27745

SINN:

ABB07_05070

KSK:

KSE_21730

KAU:	B6264_07090

KIT:	CFP65_4944

KIS:	HUT16_09340

STRH:

GXP74_26555

ABRY:

NYE86_13595

AGLA:

OIE69_08765

LXL:	KDY119_02177(rbsK)

PSIC:

J4E96_10105

MIM:	AKG07_06940

MIX:	AB663_003197

MIP:	AXH82_00785

MICR:

BMW26_11490

MPRT:

ET475_07120

MOY:	CVS54_01240(acbK)

MRN:	K8F61_08185

MPAO:

IZR02_11445

MAZA:

NFX31_05040

MELY:

L2X98_27610

MVD:	AWU67_13150

AGY:	ATC03_17930

AGM:	DCE93_00270

AGF:	ET445_02195

AMAU:

DSM26151_00790(acbK)

AMAV:

GCM10025877_32180

ALAV:

MTO99_15120

CRY:	B7495_16990

GAR:	AOZ07_07750

GLU:	F0M17_07565

GMY:

XH9_01250

GNC:	QQS42_07605

BRR:	C1N80_07505

JDE:

Jden_1355

LMOI:

VV02_02970

XCE:

Xcel_1009

IVA:	Isova_0272

CET:	B8281_01830

CCEU:

CBR64_10150

CPRT:

FIC82_019755

CFI:

Celf_2318

CGA:	Celgi_1262

CEZ:	CBP52_06665

CEJ:	GC089_07075

CELH:

GXP71_08500

CPAL:

F1D97_13725

OEK:	FFI11_019090

TED:	U5C87_02400

DSS:	GCM25873_05640(rbsK)

TFL:	RPIT_10095

KQI:	F1D05_22850

KSL:	OG809_14125

NDA:

Ndas_3511

NAL:

B005_4335

NCG:	KGD84_22195

SNAH:

OUQ99_21855

SAIU:

J4H86_24555

ACTW:

F7P10_40580

SRO:

Sros_3352

NOA:	BKM31_26065

NOW:	GBF35_20075

NCX:	Nocox_24910(kdgK4)

NGN:	LCN96_20515

NFS:	OIE67_25935

MHAI:

OHB01_32985

FAL:

FRAAL2349

NML:

Namu_1114

SESP:

BN6_77270

SSYI:

EKG83_24095

KAL:

KALB_6123

ALO:

CRK60158

UME:	RM788_07370

STP:	Strop_4175

MAU:	Micau_4674

MIL:

ML5_3626

MICB:

MicB006_3678

MTUA:

CSH63_01235

MICH:

FJK98_24800

MTEM:

GCE86_17735

MSAG:

GCM10017556_09000

VMA:	VAB18032_27656

MCRA:

ID554_23100

VER:	HUT12_25325

MENO:

Jiend_43990

MCHL:

PVK74_13490

MFEU:

H1D33_28925

MHAW:

RMN56_19700

ASE:	ACPL_1792 ACPL_3675(acbK)

AMS:	AMIS_22030

AFS:

AFR_34385

ACTS:

ACWT_1670 ACWT_3547

AIH:	Aiant_61270

ACTR:

Asp14428_14100(rbsK_2)

ACTL:

L3i22_017450

ASIC:

Q0Z83_071710

AOU:	ACTOB_001750

ATL:	Athai_20450(rbsK_2)

PRY:	Prubr_33530

CATI:

CS0771_35390 CS0771_63340(rbsK_3)

DVC:	Dvina_39925

DFU:	Dfulv_30315

DAUR:

Daura_15825

DMAT:

Dmats_34810

CAI:

Caci_2113

SNA:

Snas_4369

NAV:	JQS30_11260

GLY:	K3N28_04365

PHON:

BH719_03455

HAU:

Haur_0148

ABAT:

CFX1CAM_1639

ABAO:

BEQ56_01045

DAB:	AUC44_13735

SCD:	Spica_0068

MSIL:

METEAL_07780

MSEA:

METESE_29120

LTE:	JMUB4039_1104

FLS:	GLV81_14135

FLP:	LK994_07100

FLV:	KJS94_14640

HRS:	HER32_18960

LUT:	Lupro_02010

HWS:	RNZ46_16375

KPF:	IX53_06335

MPG:	Theba_2034

MINF:

MESINF_1227

HSN:	DV733_07275

HDS:	HSR122_2987(rbsK4)

» show all

Reference

1 [PMID:8784428]

Authors

Drepper A, Pape H

Title

Acarbose 7-phosphotransferase from Actinoplanes sp.: purification, properties, and possible physiological function.

Journal

J Antibiot (Tokyo) 49:664-8 (1996)
DOI:10.7164/antibiotics.49.664

Reference

2 [PMID:8784426]

Authors

Goeke K, Drepper A, Pape H

Title

Formation of acarbose phosphate by a cell-free extract from the acarbose producer Actinoplanes sp.

Journal

J Antibiot (Tokyo) 49:661-3 (1996)
DOI:10.7164/antibiotics.49.661

Reference

3 [PMID:11937512]

Authors

Zhang CS, Stratmann A, Block O, Bruckner R, Podeschwa M, Altenbach HJ, Wehmeier UF, Piepersberg W

Title

Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.

Journal

J Biol Chem 277:22853-62 (2002)
DOI:10.1074/jbc.M202375200

Sequence

[ase:ACPL_3675]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.187

IUBMB Enzyme Nomenclature:

2.7.1.187

ExPASy - ENZYME nomenclature database:

2.7.1.187

BRENDA, the Enzyme Database:

2.7.1.187

DBGET integrated database retrieval system