KEGG ENZYME: 2.7.1.203

ENZYME: 2.7.1.203

Entry

EC 2.7.1.203                Enzyme

Name

protein-Npi-phosphohistidine---D-glucosaminate phosphotransferase;
dgaABCD (gene names);
2-amino-2-deoxy-D-gluconate PTS permease

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

protein-Npi-phospho-L-histidine:2-amino-2-deoxy-D-gluconate Npi-phosphotransferase

Reaction(IUBMB)

[protein]-Npi-phospho-L-histidine + 2-amino-2-deoxy-D-gluconate[side 1] = [protein]-L-histidine + 2-amino-2-deoxy-D-gluconate 6-phosphate[side 2] [RN:R10407]

Reaction(KEGG)

R10407

Substrate

[protein]-Npi-phospho-L-histidine [CPD:C04261];
2-amino-2-deoxy-D-gluconate[side 1] [CPD:C03752]

Product

[protein]-L-histidine [CPD:C00615];
2-amino-2-deoxy-D-gluconate 6-phosphate[side 2] [CPD:C20589]

Comment

This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.

History

EC 2.7.1.203 created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.203

Pathway

ec00030

Pentose phosphate pathway

ec01120

Microbial metabolism in diverse environments

Orthology

K17464

D-glucosaminate PTS system EIIA component

K17465

D-glucosaminate PTS system EIIB component

Genes

EOI:	ECO111_3681 ECO111_3682

EOJ:	ECO26_4032 ECO26_4033

ECW:	EcE24377A_3276 EcE24377A_3277

ECV:	APECO1_2997 APECO1_2998

ECR:	ECIAI1_3066 ECIAI1_3067

ECI:	UTI89_C3970 UTI89_C3971

EIH:	ECOK1_3884

ECZ:	ECS88_3858 ECS88_3859

ELU:	UM146_17400 UM146_17405

ECOI:

ECOPMV1_03775(manX_5) ECOPMV1_03776(manX_6)

EAL:	EAKF1_ch2499c EAKF1_ch2500c

EMA:	C1192_15205 C1192_15210

STY:	STY4013 STY4014

STT:	t3746 t3747

SEX:	STBHUCCB_39480 STBHUCCB_39490

SENT:

TY21A_19000 TY21A_19005

STM:	STM3771 STM3772

SEO:	STM14_4547 STM14_4548

SEV:	STMMW_37601 STMMW_37611

SEY:	SL1344_3736 SL1344_3737

SEM:	STMDT12_C38280 STMDT12_C38290

SEJ:	STMUK_3757 STMUK_3758

SEB:	STM474_3945 STM474_3946

SEF:	UMN798_4099 UMN798_4100

SETU:

STU288_19055 STU288_19060

SETC:

CFSAN001921_21585 CFSAN001921_21590

SENR:

STMDT2_36541 STMDT2_36551

SEND:

DT104_37551 DT104_37561

SENI:

CY43_19560 CY43_19565

SEEN:

SE451236_02055 SE451236_02060

SPT:	SPA3621 SPA3622

SEK:	SSPA3383 SSPA3384

SPQ:	SPAB_04687 SPAB_04688

SEI:	SPC_3850 SPC_3851

SEC:	SCH_3691(ptfB) SCH_3692

SEH:	SeHA_C4101 SeHA_C4102

SHB:	SU5_04247 SU5_04248

SENH:

CFSAN002069_13175 CFSAN002069_13180

SEEH:

SEEH1578_05005 SEEH1578_05010

SEE:	SNSL254_A4050 SNSL254_A4051

SENN:

SN31241_1070 SN31241_1080

SEW:	SeSA_A3978 SeSA_A3979

SEA:	SeAg_B3996 SeAg_B3997

SENS:

Q786_18480 Q786_18485

SED:	SeD_A4164 SeD_A4165

SEG:	SG3656 SG3657

SEL:	SPUL_3790 SPUL_3791

SEGA:

SPUCDC_3776 SPUCDC_3777

SET:	SEN3593 SEN3594

SENA:

AU38_18345 AU38_18350

SENO:

AU37_18535 AU37_18540

SENV:

AU39_18540 AU39_18545

SENQ:

AU40_20670 AU40_20675

SENL:

IY59_18980 IY59_18985

SENJ:

CFSAN001992_14785 CFSAN001992_14790

SEEC:

CFSAN002050_01760 CFSAN002050_01765

SEEB:

SEEB0189_001020 SEEB0189_001025

SEEP:

I137_18190 I137_18195

SENB:

BN855_38630 BN855_38640

SENE:

IA1_18315 IA1_18320

SENC:

SEET0819_02675 SEET0819_02680

SBG:	SBG_3343 SBG_3344

SBZ:	A464_3842 A464_3843

SBV:	N643_16640 N643_16645

SALZ:

EOS98_00335 EOS98_00340

KPY:	KPNIH31_18240 KPNIH31_18245

KOX:	KOX_02420 KOX_02425

KOE:	A225_4922 A225_4923

KOY:	J415_07360 J415_07365

KOM:	HR38_00785 HR38_00790

KOK:	KONIH1_24755 KONIH1_24760

KOC:	AB185_11700 AB185_11705

EAE:	EAE_10140 EAE_10145

EAR:	CCG31961 CCG31962

KLL:	BJF97_24605 BJF97_24610

KLW:	DA718_04740 DA718_04745

KGR:	JJJ10_04755 JJJ10_04760

KPAS:

LUW96_02300 LUW96_02305

KLC:	K7H21_04240 K7H21_04245

REE:	electrica_04414 electrica_04415(levE)

RAO:	DSD31_22465 DSD31_22470

RTG:	NCTC13098_03935(manX_7) NCTC13098_03936(manX_8) NCTC13098_06470 NCTC13098_06471(levE)

CKO:	CKO_05131 CKO_05132

CFD:	CFNIH1_06355 CFNIH1_06360

CBRA:

A6J81_17515 A6J81_17520

CWE:	CO701_22375 CO701_22380

CYO:	CD187_00250 CD187_00255

CPOT:

FOB25_11655 FOB25_11660

CSED:

JY391_00250 JY391_00255

CAMA:

F384_19960 F384_19965

CAF:	AL524_02745 AL524_02750

CIF:	AL515_01055 AL515_01060

CFAR:

CI104_00295 CI104_00300

CIR:	C2U53_09400 C2U53_09405

CIE:	AN232_04660 AN232_04665

CPAR:

CUC49_18970 CUC49_18975

CTEL:

GBC03_04065 GBC03_04070

CARS:

E1B03_25895 E1B03_25900

CIX:	M4I31_00235 M4I31_00240

CEM:	LH23_01840 LH23_01845

CEN:	LH86_01835 LH86_01840

ESC:	Entcl_3811 Entcl_3812

KLE:	AO703_02845 AO703_02850

YRE:	HEC60_20740 HEC60_20745

SUPE:

P0H77_00300 P0H77_00305

TOE:	QMG90_02945 QMG90_02950

EBB:	F652_585 F652_586

SFW:	WN53_22590 WN53_22595

SFG:	AV650_18420 AV650_18425

SOF:	NCTC11214_04106 NCTC11214_04107(levE)

SGL:	SG2426 SG2427

SOD:	Sant_0067 Sant_0068

HAV:	AT03_07685 AT03_07690

HPAR:

AL518_17880 AL518_17885

OPO:	DSM2777_12975 DSM2777_12980

PRAG:

EKN56_11355 EKN56_11360

ORB:	IPMB12_08385 IPMB12_08390 IPMB12_11185

JEU:	BJP62_06010 BJP62_06015

JES:	JHS3_16550 JHS3_16560

PMAS:

NCF86_16805 NCF86_16810

DMA:

DMR_25820

DCB:	C3Y92_11925

OJD:	NP439_23215 NP439_23220

OON:	NP440_16450

VIR:	X953_16400 X953_16405

PMAE:

LMZ02_12140 LMZ02_12145

LPAA:

BHS01_08870

LAW:	LACWKB8_0071 LACWKB8_1712

LKL:	DKL58_02470 DKL58_08925

LHS:	DLD54_00345 DLD54_08120

LCZ:	LCAZH_2764

LCS:	LCBD_0390 LCBD_0415 LCBD_0416 LCBD_2951

LCE:	LC2W_0385 LC2W_0410 LC2W_0411 LC2W_2925

LCW:	BN194_03940 BN194_04200(manX) BN194_04210(manX_2) BN194_28660(levE_5)

LCL:	LOCK919_0433 LOCK919_3015

LPI:	LBPG_01356

LCB:	LCABL_03870(sipB) LCABL_04120(ptnA) LCABL_04130(ptfB)

LCX:	LCA12A_0450

LACA:

LAC1533_2217

LHO:	LOOC260_108700

EFA:	EF2979 EF2980

EFL:	EF62_0065(mopB) EF62_0066(mopA)

EFI:	OG1RF_12261 OG1RF_12262

EFD:	EFD32_2559 EFD32_2560

EFS:	EFS1_2414 EFS1_2415

EFN:	DENG_02865(manX) DENG_02866(manX)

EFQ:	DR75_1709 DR75_1710

ENE:	ENT_27240 ENT_27250

EGA:	AL523_14025

EGV:	EGCR1_00400 EGCR1_00405 EGCR1_06920

EAV:	EH197_04875 EH197_05755 EH197_13405 EH197_13430 EH197_20170 EH197_22810

ERAF:

J9537_02295 J9537_02300 J9537_17040

TOO:	C7K38_07815

AUR:	HMPREF9243_0281

AUN:	AWM73_08030

ABAE:

CL176_01980

MARR:

BKP56_11400

CINT:

HZF06_04025

PETR:

QKW49_07350 QKW49_07375

BHV:	BLHYD_30600(sorB)

CSH:	Closa_1940

ARF:	AR1Y2_0100 AR1Y2_0199 AR1Y2_0228 AR1Y2_0500 AR1Y2_0556 AR1Y2_0557 AR1Y2_0584 AR1Y2_1427 AR1Y2_2500 AR1Y2_3267 AR1Y2_3371 AR1Y2_3428

ACAC:

EYQ97_00595 EYQ97_01005 EYQ97_01475 EYQ97_08030 EYQ97_11065 EYQ97_13895 EYQ97_14100 EYQ97_14110 EYQ97_15510 EYQ97_16525

CBOL:

CGC65_04935

GFE:	Gferi_12420

CDF:	CD630_02860 CD630_02870

PDC:	CDIF630_00410 CDIF630_00411 CDIF630_00621

CDC:	CD196_0302 CD196_0303 CD196_0449

CDL:	CDR20291_0289 CDR20291_0290 CDR20291_0435

PDF:	CD630DERM_02860 CD630DERM_02870 CD630DERM_04920

TTE:

TTE0193

TEX:	Teth514_0135

THX:

Thet_0171

TPD:	Teth39_2067

TIT:

Thit_0168

TMT:	Tmath_0225

TBO:	Thebr_2112

TWI:	Thewi_1906 Thewi_1910 Thewi_2122

TTM:	Tthe_1735 Tthe_2469

TXY:	Thexy_0798

TSH:

Tsac_2503

TEP:	TepRe1_1694 TepRe1_1698 TepRe1_2538

TAE:	TepiRe1_1826 TepiRe1_1830 TepiRe1_1831 TepiRe1_2736

BACG:

D2962_15355

TOC:	Toce_0295 Toce_1900 Toce_1904

KME:	H0A61_00398(sorB)

SPOA:

EQM13_03010 EQM13_03935 EQM13_06690 EQM13_09900 EQM13_11945 EQM13_14140 EQM13_14145

PUF:

UFO1_0311

PFT:	JBW_03181 JBW_03182 JBW_04324

ERD:	G7062_03590 G7062_03625

EIO:	H9L01_05360

LCG:	L3BBH23_01770

ERB:	A4V01_00185 A4V01_00635 A4V01_01190 A4V01_02605 A4V01_02640 A4V01_03885 A4V01_04100 A4V01_04820 A4V01_09745 A4V01_21605 A4V01_21685

CIU:	G4D55_00860 G4D55_00895 G4D55_02060 G4D55_02265 G4D55_03155 G4D55_08505 G4D55_17265 G4D55_18945 G4D55_19060 G4D55_19320 G4D55_19715 G4D55_20465

FCZ:	IMF26_09080 IMF26_09085

TIO:	INP52_09200

CGO:	Corgl_1551

COLL:

KPC83_05495

STR:	Sterm_0951 Sterm_3205 Sterm_3206 Sterm_3863 Sterm_3864

GGR:	HKW67_06895

CPO:	COPRO5265_1192

TMG:	US01_C0001G0873

» show all

Reference

1 [PMID:23836865]

Authors

Miller KA, Phillips RS, Mrazek J, Hoover TR

Title

Salmonella utilizes D-glucosaminate via a mannose family phosphotransferase system permease and associated enzymes.

Journal

J Bacteriol 195:4057-66 (2013)
DOI:10.1128/JB.00290-13

Sequence

[seo:STM14_4548 STM14_4547]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.203

IUBMB Enzyme Nomenclature:

2.7.1.203

ExPASy - ENZYME nomenclature database:

2.7.1.203

BRENDA, the Enzyme Database:

2.7.1.203

All links

Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (725)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (434)   
   KEGG MGENES (180)   
   RefGene (109)   
Protein sequence (2)   
   UniProt (2)   
DNA sequence (4)   
   GenBank (2)   
   EMBL (2)   
All databases (742)   

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