KEGG ENZYME: 2.7.1.218

ENZYME: 2.7.1.218

Entry

EC 2.7.1.218                Enzyme

Name

fructoselysine 6-kinase;
frlD (gene name)

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:D-fructosyl-L-lysine 6-phosphotransferase

Reaction(IUBMB)

ATP + N6-(D-fructosyl)-L-lysine = ADP + N6-(6-phospho-D-fructosyl)-L-lysine [RN:R08124]

Reaction(KEGG)

R08124

Substrate

ATP [CPD:C00002];
N6-(D-fructosyl)-L-lysine [CPD:C16488]

Product

ADP [CPD:C00008];
N6-(6-phospho-D-fructosyl)-L-lysine

Comment

The enzyme, characterized from the bacterium Escherichia coli, has very little activity with fructose.

History

EC 2.7.1.218 created 2017

Orthology

K10710

fructoselysine 6-kinase

Genes

ECO:	b3374(frlD)

ECJ:	JW3337(frlD)

ECD:	ECDH10B_3549(frlD)

EBW:	BWG_3065(frlD)

ECOK:

ECMDS42_2820(frlD)

ECOC:

C3026_18315

ECE:	Z4734 Z4735

ELX:	CDCO157_3965

EOI:	ECO111_4183(frlD)

EOJ:	ECO26_4462(frlD)

EOH:	ECO103_4092(frlD)

ESL:

O3K_02200

ESO:

O3O_23450

ESM:

O3M_02245

ECK:	EC55989_3779(frlD)

ELH:

ETEC_3624

ECW:	EcE24377A_3843

EUN:	UMNK88_4139

ECOA:

APECO78_20660

ECX:	EcHS_A3569

ECY:

ECSE_3635

ECR:	ECIAI1_3512(frlD)

EBR:	ECB_03224(yhfQ)

ECOB:

C3029_20875

EBL:	ECD_03224(frlD)

EBE:	B21_03176(frlD)

EBD:

ECBD_0375

ELO:	EC042_3635(frlD)

ECL:	EcolC_0339

EKO:	EKO11_0371

EKF:	KO11_05930(frlD)

EDH:	EcDH1_0339

EDJ:	ECDH1ME8569_3253(frlD)

ELW:	ECW_m3629(frlD)

ELL:	WFL_17725(frlD)

ELP:	P12B_c3472(yhfQ)

ECOL:

LY180_17300

ERUY:

OSH18_11025(frlD)

STM:

STM3600

SEO:	STM14_4330

SEV:	STMMW_35891

SEY:	SL1344_3565

SEJ:	STMUK_3585

SEB:	STM474_3768

SEF:	UMN798_3905

SETU:

STU288_18185

SETC:

CFSAN001921_22450

SENR:

STMDT2_34851

SEND:

DT104_35831

SENI:

CY43_18685

SEEN:

SE451236_02915

SPQ:	SPAB_04469

SEI:

SPC_3674

SEC:	SCH_3534(yurL)

SEH:	SeHA_C3914

SHB:

SU5_04074

SENH:

CFSAN002069_14055

SEEH:

SEEH1578_04070

SEE:	SNSL254_A3872

SENN:

SN31241_2880

SEW:	SeSA_A3794

SEA:	SeAg_B3806

SENS:

Q786_17580

SED:

SeD_A3975

SEG:

SG3837

SEL:

SPUL_3973

SEGA:

SPUCDC_3959

SET:

SEN3423

SENA:

AU38_17465

SENO:

AU37_17655

SENV:

AU39_17660

SENQ:

AU40_19660

SENL:

IY59_18095

SENJ:

CFSAN001992_15640

SEEC:

CFSAN002050_24955

SEEB:

SEEB0189_001880

SEEP:

I137_19040

SENB:

BN855_36780

SENE:

IA1_17465

SENC:

SEET0819_01720

SES:	SARI_04036

SBG:	SBG_3195(frlD)

SBZ:

A464_3678

SBV:	N643_15885

SALZ:

EOS98_01305

SFL:	SF3392(yhfQ)

SFX:	S4370(yhfQ)

SFV:	SFV_3379(yhfQ)

SFE:	SFxv_3703(frlD)

SFN:

SFy_4820

SFS:

SFyv_4895

SFT:	NCTC1_03673(frlD)

SSN:	SSON_3505(yhfQ)

SBO:	SBO_3361(yhfQ)

SBC:	SbBS512_E3751

SHQ:	A0259_20615

ESA:

ESA_04362

CSK:	ES15_0289(frlD)

CSZ:	CSSP291_20090

CSJ:	CSK29544_01247

CCON:

AFK62_18485

CDM:	AFK67_19050

CSI:	P262_00432

CMJ:	AFK66_001490

CUI:	AFK65_18220

CMW:	AFK63_00180

CTU:	CTU_38900(frlD)

KPM:	KPHS_05080

KPH:	KPNIH24_02610

KPV:	KPNIH29_27125

KPW:	KPNIH30_02745

KPG:	KPNIH32_02755

KPC:	KPNIH10_02595

KPQ:	KPR0928_02600

KPT:	VK055_2804

KPO:	KPN2242_01360

KPJ:

N559_4635

KPI:	D364_23700

KPA:	KPNJ1_04959

KPS:	KPNJ2_04908

KPB:	FH42_19675

KPNE:

KU54_023990

KPNU:

LI86_23830

KQU:	AVR78_26505

KQV:	B8P98_28500

KPAS:

LUW96_09475

CFD:	CFNIH1_05180

CFAR:

CI104_00385 CI104_01830

CIE:	AN232_05650

CIX:	M4I31_01150

KOR:	AWR26_23150

KRD:	A3780_00625

SYM:	K6K13_17755

AHN:	NCTC12129_00401(frlD_1) NCTC12129_00624(frlD_2)

ASUB:

NLZ15_01645(frlD) NLZ15_02735

KIN:	AB182_27495

PDZ:	HHA33_04270(frlD) HHA33_25110

METY:

MRY16398_04130(frlD) MRY16398_49900

IZH:	FEM41_17955

TOE:	QMG90_04770

EBC:	C2U52_04405 C2U52_10300

SFW:	WN53_23555

RAH:	Rahaq_1897

RAQ:	Rahaq2_1680

RAA:

Q7S_09315

GQU:	AWC35_07295 AWC35_23960

PARI:

I2D83_01700

BGJ:	AWC36_18630

BRB:	EH207_07775

BNG:	EH206_12000

BIZ:	HC231_23640

LBQ:	CKQ53_05705

LPOP:

I6N93_00345

PANT:

PSNIH1_p00420

PAGC:

BEE12_20910

PVD:	CFBP1590__2976

PLUL:

FOB45_03630

PVK:	EPZ47_17040

PBZ:	GN234_29555

PALV:

KSS97_17475

PCAS:

LOY40_16780

PNB:	NK667_11575

LGT:	E4T54_11445

WOC:	BA177_05455

BUM:	AXG89_20480

MAM:	Mesau_02913

AAK:	AA2016_1157

SME:

SMc03138

SMK:	Sinme_3010

SMQ:	SinmeB_2784

SMX:	SM11_chr3126

SMI:	BN406_02811 BN406_03672

SMEG:

C770_GR4Chr3084

SMEL:

SM2011_c03138

SMER:

DU99_16275

SMD:	Smed_2845 Smed_5455

RHI:	NGR_b21930

SFD:	USDA257_c23170(frlD)

SIX:	BSY16_5367

SAME:

SAMCFNEI73_pC0439(frlD)

SINO:

SS05631_b62630

ESJ:	SJ05684_b42990

EAK:	EKH55_4762

ENU:	PYH37_001617

SKM:	PZL22_003273

STEG:

QA637_20220

EAD:	OV14_b0619

EAH:	FA04_29325

ECAA:

J3R84_33195

ATF:	Ach5_51770

AGT:	EYD00_23585

ALF:	CFBP5473_24035

AVV:	RvVAT039_pl06550

RPUS:

CFBP5875_23630 CFBP5875_23705

AVI:

Avi_9147

ROY:	G3A56_16560

RBAN:

J2J98_24605

RBW:	RLCC275e_34245

NGL:	RG1141_PA11750

NGG:	RG540_PA11150

SOJ:	K6301_18200

SSUM:

Q9314_21690

OIN:	IAR37_21955

OPS:	A8A54_22965

BPSN:

NIK97_18420

OCR:	HGK82_23085

BVV:	BHK69_06580

BOF:	FQV39_06035

BVES:

QO058_02515

NOH:	G5V57_10130

SULD:

B5M07_17975

SINL:

DSM14862_03568(frlD)

RSP:

RSP_3945

RSQ:	Rsph17025_3647

RSK:	RSKD131_4343

CAZT:

LV780_17510

RCP:	RCAP_rcp00007(frlD)

PARS:

DRW48_05625

PARR:

EOJ32_19800

PSAP:

JHX88_17595

DAA:	AKL17_2269

THAS:

C6Y53_19120 C6Y53_19130

PBAE:

P8S53_16250

HTQ:	FRZ44_02800(frlD)

HADH:

FRZ61_03170(frlD)

PAQI:

KW060_10630

BSU:	BSU32570(frlD)

BSR:

I33_3361

BSL:

A7A1_2473

BSH:	BSU6051_32570(frlD)

BSY:	I653_15710

BSUT:

BSUB_03476(frlD)

BSUL:

BSUA_03476(frlD)

BSUS:

Q433_17825

BSO:	BSNT_09743(yurL)

BSN:	BSn5_07185

BSQ:	B657_32570(frlD)

BSX:	C663_3116(frlD)

BSP:	U712_16250

BSS:	BSUW23_15905(frlD)

BST:

GYO_3557

BIT:	BIS30_05865

BAY:	RBAM_029630

BAQ:	BACAU_2990(yurL)

BYA:	BANAU_3149(yurL)

BAMP:

B938_15170

BQY:	MUS_3551(yhfQ1)

BAML:

BAM5036_2876(frlD)

BAMA:

RBAU_3092(frlD)

BAMN:

BASU_2880(frlD)

BAMB:

BAPNAU_3140(frlD)

BAMT:

AJ82_16770

BAMY:

V529_32240(yurL)

BMP:	NG74_03111(frlD)

BAO:	BAMF_3052(frlD)

BAZ:	BAMTA208_16450(frlD)

BQL:	LL3_03329(frlD)

BXH:	BAXH7_03356(yurL)

BAMI:

KSO_004340

BAMC:

U471_30700

BAMF:

U722_15945

BSIA:

CWD84_04375

BAE:	BATR1942_14215

BVM:	B9C48_15130

BSON:

S101395_04163(frlD)

BHT:	DIC78_14910

BMOJ:

HC660_31390(frlD)

BTEQ:

G4P54_16645

BIQ:	AN935_16355

BSTR:

QI003_19750(frlD)

BIF:	N288_10525 N288_22675

BGY:

BGLY_3826

BCAB:

EFK13_16705

BRY:	M0696_16405

BJS:

MY9_3292

BACP:

SB24_13925

BACB:

OY17_18135

BACY:

QF06_14605

BACL:

BS34A_35540(frlD)

BALM:

BsLM_3254

BACS:

AUL54_14855

BACQ:

DOE78_04980 DOE78_09260 DOE78_10715 DOE78_24360

BHAI:

KJK41_04505

BCOH:

BC6307_07045 BC6307_07415

BCIR:

C2I06_15325 C2I06_21500 C2I06_21525

NTX:	NQZ71_16615 NQZ71_20610 NQZ71_20635(frlD)

BMQ:	BMQ_2407(yurL)

BMD:	BMD_2372(yurL)

BMEG:

BG04_4781(frlD) BG04_614(frlD)

BEO:	BEH_13920 BEH_25895

BGI:	BGM20_10395

CGOT:

J1899_20170

OON:	NP440_19430

FEC:	QNH15_22965

APAK:

AP3564_15310

BSJ:	UP17_08925

PFRI:

L8956_09430(frlD) L8956_15560

POF:	GS400_06225

NDT:	L1999_13750(frlD) L1999_28465 L1999_29045(frlD)

NCM:	QNK12_02365(frlD) QNK12_16585 QNK12_30195

MEKU:

HUW50_22125 HUW50_22160(frlD) HUW50_22225

MLIT:

KDJ21_018505 KDJ21_018720

BOU:	I5818_04375

GAJ:	MY490_01360(frlD)

DOM:	RRU94_02645 RRU94_02865 RRU94_06230 RRU94_16910(frlD)

STEA:

C0679_02850

BCHS:

JNE38_06905 JNE38_13550

BPAB:

PSE45_14775

BHUI:

LOK74_18005

PPM:	PPSC2_02775(yhfQ) PPSC2_03815(frlD1) PPSC2_08135(frlD3)

PPO:	PPM_0496(yhfQ) PPM_0707(frlD1) PPM_1541(frlD3)

PPOL:

X809_03340

PPQ:	PPSQR21_005290(rbsK) PPSQR21_007400

PPOY:

RE92_04045 RE92_08170 RE92_09170

PMS:	KNP414_05710 KNP414_07065

PMQ:	PM3016_5052 PM3016_6656

PMW:	B2K_26185 B2K_33630

PGM:	PGRAT_06025 PGRAT_06570 PGRAT_22600 PGRAT_32010

POD:	PODO_22805

PRI:	PRIO_1384(frlD) PRIO_4583 PRIO_4875 PRIO_4891 PRIO_6652

PSON:

JI735_07935 JI735_07940 JI735_08235(frlD) JI735_15030 JI735_30680 JI735_32030 JI735_32105

PPEO:

ABE82_03575

PDH:	B9T62_22420

PIB:	BBD41_28615

PCHI:

PC41400_26465

PTRI:

KDC22_26585(frlD) KDC22_26610

PMAE:

LMZ02_11860 LMZ02_14705 LMZ02_14715(frlD)

PKP:	SK3146_00358(frlD_1) SK3146_04870(frlD_2)

EFF:	skT53_15460

PGQ:	FK545_05430

LKL:	DKL58_02655

LAPI:

DKL56_02075

LPAI:

GYM71_03010

LXO:	KIM322_04120(frlD)

LCA:

LSEI_2086

LCZ:	LCAZH_2049

LCS:

LCBD_2246

LCE:

LC2W_2227

LCW:	BN194_22240(frlD)

LCL:	LOCK919_2265

LPQ:	AF91_03305

LPI:	LBPG_02008

LPAP:

LBPC_2027

LCB:	LCABL_22650(mocE)

LCX:	LCA12A_0197

LRH:

LGG_02086

LRG:

LRHM_2005

LRL:	LC705_02081

LRA:

LRHK_2086

LRO:	LOCK900_2035

LRC:	LOCK908_2147

LCHI:

KG086_09145

LZE:	KG087_09730

LHN:	LHUE1_000191

LVA:	LV515_01340

LNG:	BSQ50_11615

LHW:	BSQ49_12120 BSQ49_12375

LFM:	LF20184_06305

CPAB:

G6534_05555

EFU:	HMPREF0351_12786 HMPREF0351_12897

EAV:	EH197_08835

ESG:	EsVE80_03190

ERAF:

J9537_17635

EDS:	PML78_06080

EMS:	P3T75_11770

CAC:

CA_C3498

CAE:	SMB_G3536(frlD)

CAY:

CEA_G3502

CBE:	Cbei_0960 Cbei_4798

CBZ:	Cbs_0960 Cbs_4798

CBEI:

LF65_05347

CDY:	F3K33_05065 F3K33_24485

CMAH:

C1I91_18280 C1I91_18315

PROQ:

P6M73_11440(frlD) P6M73_13045

ESR:

ES1_09720

ESU:

EUS_03950

RAL:	Rumal_2339

RCH:

RUM_11890

RUM:

CK1_13150

OBJ:	EIO64_04090

LASA:

L9O85_11450

PETR:

QKW49_05045(frlD) QKW49_09095

CAPR:

EQM14_03780

CFEM:

HCR03_02570 HCR03_02575(frlD) HCR03_07435(frlD) HCR03_07465(frlD)

IBU:	IB211_00949c

BPRS:

CK3_35120

CCT:

CC1_07220

CCOM:

I6K69_13935

CEV:	LK421_04375

BYL:	A4V09_17710

BPRO:

PMF13cell1_00269(frlD)

BLAB:

EYS05_04870

BLIQ:

INP51_14435

BMAS:

LK422_00190

BLAR:

LC508_16520(frlD)

BCOC:

BLCOC_03680(frlD)

LACY:

A4V08_03760 A4V08_11195 A4V08_11255 A4V08_13840

CHYL:

CE91St63_25330

CSH:	Closa_1463 Closa_1470 Closa_3643 Closa_4036

CSO:	CLS_33460 CLS_33560

ACHT:

bsdcttw_02030(frlD_1) bsdcttw_02040 bsdcttw_19450(frlD_2) bsdcttw_19510 bsdcttw_19710

RGN:	RGna_06845

CBOL:

CGC65_02995 CGC65_24950 CGC65_24955

CASP:

NQ535_13765(frlD) NQ535_13800(frlD)

DLO:	K5I24_08000

LBW:	C3V36_02990 C3V36_08220

VPY:	HZI73_11500

AMT:

Amet_1349

GFE:	Gferi_09760

CST:	CLOST_1206(frlD)

HAS:	Halsa_0744

HALS:

D7D81_02955 D7D81_15635

IFN:	GM661_00255 GM661_12770

OLS:	Olsu_0626 Olsu_1405 Olsu_1406

ATB:	J4859_01715

TIO:	INP52_03690

CGO:	Corgl_0707 Corgl_0708

CAER:

CSV91_01210 CSV91_08930

SHY:	SHJG_1054 SHJG_1747

SHO:	SHJGH_0887 SHJGH_1512

SCI:	B446_03110

SRIM:

CP984_37660

SDD:	D9753_34795

SARG:

HKX69_34300

SCT:	SCAT_p1059

SCY:	SCATT_p06770

MIP:	AXH82_02795

MCW:	A8L33_05035

MAUR:

BOH66_14855

MLV:	CVS47_02163(frlD)

MCHN:

HCR76_13515 HCR76_15755 HCR76_15785

MRN:	K8F61_14385

MPAO:

IZR02_12960

MSUW:

GCM10025863_26010

CPHY:

B5808_17065

HUM:	DVJ78_03895

LEU:	Leucomu_00575 Leucomu_00595

LTN:	KVY00_09945

HEA:	HL652_14610

ARR:	ARUE_c04100

AAGI:

NCTC2676_1_00619(frlD)

AAU:

AAur_0441

GMI:	NMP99_15440

GMY:

XH9_05240

CELC:

K5O09_17280

BLUT:

EW640_07195

AJI:	C0Z10_01365

MPH:	MLP_21790 MLP_21820

PROP:

QQ658_03160

MGG:	MPLG2_2639

SRO:

Sros_0298

NOA:	BKM31_09000

NOW:	GBF35_46635

NGN:	LCN96_32450

BCOR:

BCOR_0209

BII:	BINDI_0145

ABAO:

BEQ56_11695

KBS:	EPA93_13655

DDR:	Deide_3p00190

DMR:	Deima_0079

DFC:

DFI_15970

DTAE:

LAJ19_18210

TSC:	TSC_p800050

BHC:	JFL75_10480

EPO:	Epro_0778(pfkB)

FVA:	FV113G1_03710

KOS:	KORDIASMS9_03201(frlD)

MIB:	UY43_C0001G0083

» show all

Reference

1 [PMID:12147680]

Authors

Wiame E, Delpierre G, Collard F, Van Schaftingen E

Title

Identification of a pathway for the utilization of the Amadori product fructoselysine in Escherichia coli.

Journal

J Biol Chem 277:42523-9 (2002)
DOI:10.1074/jbc.M200863200

Sequence

[eco:b3374]

Reference

2 [PMID:14641112]

Authors

Wiame E, Van Schaftingen E

Title

Fructoselysine 3-epimerase, an enzyme involved in the metabolism of the unusual Amadori compound psicoselysine in Escherichia coli.

Journal

Biochem J 378:1047-52 (2004)
DOI:10.1042/BJ20031527

Sequence

[eco:b3374]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.218

IUBMB Enzyme Nomenclature:

2.7.1.218

ExPASy - ENZYME nomenclature database:

2.7.1.218

BRENDA, the Enzyme Database:

2.7.1.218

DBGET integrated database retrieval system