KEGG ENZYME: 2.7.1.223

ENZYME: 2.7.1.223

Entry

EC 2.7.1.223                Enzyme

Name

aminoimidazole riboside kinase;
STM4066 (locus name)

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:5-amino-1-(beta-D-ribosyl)imidazole 5'-phosphotransferase

Reaction(IUBMB)

ATP + 5-amino-1-(beta-D-ribosyl)imidazole = ADP + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole [RN:R12245]

Reaction(KEGG)

R12245

Substrate

ATP [CPD:C00002];
5-amino-1-(beta-D-ribosyl)imidazole [CPD:C22030]

Product

ADP [CPD:C00008];
5-amino-1-(5-phospho-beta-D-ribosyl)imidazole [CPD:C03373]

Comment

The enzyme, characterized from the bacterium Salmonella enterica, can phosphorylate exogeneously-provided 5-amino-1-(beta-D-ribosyl)imidazole to form 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole (AIR), an important intermediate in the production of both purine mononucleotides and the hydroxymethyl pyrimidine moiety of thiamine.

History

EC 2.7.1.223 created 2018

Orthology

K23147

aminoimidazole riboside kinase

Genes

STY:

STY3804

STT:

t3552

SEX:	STBHUCCB_37350

SENT:

TY21A_17945

STM:

STM4066

SEO:	STM14_4890

SEV:	STMMW_40311

SEY:	SL1344_4015

SEM:	STMDT12_C42130

SEJ:	STMUK_4051

SEB:	STM474_4248

SEF:	UMN798_4410

SETU:

STU288_20480

SETC:

CFSAN001921_20090

SENR:

STMDT2_39291

SEND:

DT104_40751

SENI:

CY43_21265

SEEN:

SE451236_00560

SPT:

SPA3909

SEK:

SSPA3637

SPQ:	SPAB_05039

SEI:

SPC_4173

SEC:

SCH_3957

SEH:	SeHA_C4397

SHB:

SU5_0164

SENH:

CFSAN002069_11740

SEEH:

SEEH1578_06590

SEE:	SNSL254_A4395

SENN:

SN31241_46210

SEW:	SeSA_A4283

SEA:	SeAg_B4312

SENS:

Q786_19970

SED:

SeD_A4464

SEL:

SPUL_3598

SEGA:

SPUCDC_3584

SET:

SEN3856

SENA:

AU38_19935

SENO:

AU37_19950

SENV:

AU39_19970

SENQ:

AU40_22275

SENL:

IY59_20430

SENJ:

CFSAN001992_13355

SEEC:

CFSAN002050_03220

SEEB:

SEEB0189_022015

SENB:

BN855_41410

SENE:

IA1_19785

SENC:

SEET0819_04175

SALZ:

EOS98_21980

KMI:	VW41_00365

KLW:	DA718_00640

KGR:	JJJ10_00575

KPAS:

LUW96_06020

KLC:	K7H21_00505

KLM:	BWI76_27485

RON:	TE10_01710

CAMA:

F384_21510

CFAR:

CI104_24190

CIR:	C2U53_10880

CTEL:

GBC03_05735

CLAP:

NCTC11466_04506(iolC_2)

AHN:	NCTC12129_04849(iolC_3)

ASUB:

NLZ15_21650

IZH:	FEM41_06220

SUPE:

P0H77_00670

SFW:	WN53_14485

SOF:	NCTC11214_00360(iolC_1)

DAA:	AKL17_4383

ARF:	AR1Y2_1679

ACAC:

EYQ97_09235

AMAU:

DSM26151_01060(rbkS_1)

MAU:	Micau_4254

MTUA:

CSH63_03360

BLF:

BLIF_1540

BLB:	BBMN68_1805

BLG:

BIL_02100

BLZ:	BLGT_07945

BBV:	HMPREF9228_1467

BBRU:

Bbr_1426

BBRV:

B689b_1442

BBRN:

B2258_1405

BBRS:

BS27_1451

BLEM:

BL8807_05360

TRS:	Terro_3093

BLQ:	L21SP5_01080(iolC)

SLI:

Slin_1088

SPIK:

EXU85_13095

SPIB:

G8759_24160

FIB:	A6C57_12050

HTS:	HMJ29_11980

AFLA:

FHG64_10450

MZI:	HWN40_11890

» show all

Reference

1 [PMID:12486071]

Authors

Dougherty M, Downs DM

Title

The stm4066 gene product of Salmonella enterica serovar Typhimurium has aminoimidazole riboside (AIRs) kinase activity and allows AIRs to satisfy the thiamine requirement of pur mutant strains.

Journal

J Bacteriol 185:332-9 (2003)
DOI:10.1128/JB.185.1.332-339.2003

Sequence

[stm:STM4066]

Reference

2 [PMID:15458630]

Authors

Zhang Y, Dougherty M, Downs DM, Ealick SE

Title

Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily.

Journal

Structure 12:1809-21 (2004)
DOI:10.1016/j.str.2004.07.020

Sequence

[stm:STM4066]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.223

IUBMB Enzyme Nomenclature:

2.7.1.223

ExPASy - ENZYME nomenclature database:

2.7.1.223

BRENDA, the Enzyme Database:

2.7.1.223

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (92)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (91)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (5)   
   InterPro (5)   
All databases (106)   

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